rospedРоссийский педиатрический журнал имени М.Я. СтуденикинаM.Ya. Studenikin Russian Pediatric Journal3033-90063033-9014ФГАУ «НМИЦ здоровья детей» Минздрава России10.46563/1560-9561-2023-26-3-212-217mdzwlirosped-11Research ArticleОБЗОРЫREVIEWSДефицит витамина D у детей и патология органов пищеваренияVitamin D deficiency in children and pathology of the digestive systemhttps://orcid.org/0000-0003-3842-9147ПоливановаТамара ВладимировнаPolivanovaTamara V.

Доктор мед. наук, гл. науч. сотр., клиническое отделение патологии пищеварительной системы у взрослых и детей «НИИ медицинских проблем Севера» — обособленного подразделения ФГБНУ ФИЦ «Красноярский научный центр» СО РАН

e-mail: tamara-polivanova@yandex.ru

Dr. Sci. (Med.), Chief scientist, Clinical division of digestive system pathology in adults and children, Federal Research Center «Krasnoyarsk Science Center» of the Siberian Branch of the Russian Academy of Sciences — Scientific Research Institute for Medical Problems of the North, Krasnoyarsk, Russian Federation

e-mail: tamara-polivanova@yandex.ru

tamara-polivanova@yandex.ruhttps://orcid.org/0000-0002-1410-8747ВшивковВиталий АлексеевичVshivkovVitaliy A.

Канд. мед. наук, ст. науч. сотр., ФГБНУ ФИЦ Красноярский научный центр СО РАН «НИИ медицинских проблем Севера»

e-mail: vitali1983@mail.ru

vitali1983@mail.ruhttps://orcid.org/0000-0002-7930-7130АникинаКсения АлександровнаAnikinaKseniya A.

Аспирант, ФГБНУ ФИЦ Красноярский научный центр СО РАН «НИИ медицинских проблем Севера»

e-mail:  ksenia.anikina@mail.ru

ksenia.anikina@mail.ru«Научно-исследовательский институт медицинских проблем Севера» — обособленное подразделение ФГБНУ «Федеральный исследовательский центр «Красноярский научный центр» Сибирского отделения Российской академии наукРоссияKrasnoyarsk Science Center of the Siberian Branch of the Russian Academy of Sciences — Scientific Research Institute for Medical Problems of the NorthRussian Federation202309082023263212217Copyright © Поливанова Т.В., Вшивков В.А., Аникина К.А., 20232023Поливанова Т.В., Вшивков В.А., Аникина К.А.Polivanova T.V., Vshivkov V.A., Anikina K.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rosped.ru/jour/article/view/11

В обзоре показана связь дефицита витамина D с различными формами патологии органов желудочно-кишечного тракта. Распространённость дефицита витамина D в России имеет региональные и возрастные особенности и достигает 42%. Установлено, что кроме ключевой роли в качестве регулятора кальциевого обмена, обеспечивающего рост и формирование структуры костной ткани, витамин D влияет на течение различных форм патологии желудочно-кишечного тракта. При этом он выступает как регулятор врождённого иммунитета. В других случаях эффекты витамина D направлены на активацию противовоспалительных факторов, которые обусловливают его позитивное влияние на течение болезней посредством антиоксидантного действия. Представлены данные о влиянии дефицита витамина D на формирование различных форм патологии кишечника с воспалительным и иммунным механизмом развития. Авторы указывают на первичность дефицита витамина D при воспалительных заболеваниях кишечника. Независимо от первичности воспалительных заболеваний кишечника или дефицита витамина D коррекция последнего оказывает выраженное положительное влияние на течение заболевания.

Участие авторов

Участие авторов: Поливанова Т.В. — концепция и дизайн исследования; Вшивков В.А. — сбор и обработка материала; Вшивков В.А., Аникина К.А. — статистическая обработка; Поливанова Т.В., Аникина К.А. — написание текста; Поливанова Т.В. — редактирование. Все соавторы — утверждение окончательного варианта статьи, ответственность за целостность всех частей статьи.

Финансирование

Финансирование. Исследование не имело финансовой поддержки.

Конфликт интересов

Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов. 

Поступила 21

Поступила 21.04.2023Принята к печати 16.05.2023Опубликована 27.06.2023

The review shows the relationship of vitamin D deficiency (VDD) with various forms of pathology of the gastrointestinal tract. The VDD prevalence in Russia has regional and age characteristics and reaches 42%. In addition to the key role as a regulator of calcium metabolism, which ensures the growth and formation of the structure of bone tissue, vitamin D was established to affect the course of various forms of pathology of the gastrointestinal tract.  At the same time, it acts as a regulator of innate immunity.  In other cases, the effects of vitamin D are aimed at activating anti-inflammatory factors, which determine its positive effect on the course of diseases through antioxidant action.  Data on the VDD impact on the formation of various forms of intestinal pathology with an inflammatory and immune mechanism of development are presented. The authors point to the VDD impact in inflammatory bowel diseases.  Regardless of the VDD primacy of inflammatory bowel disease, the correction of the VDD has a pronounced positive effect on the course of the disease.

Contribution

Contribution: Polivanova T.V. — concept and design of the study; Vshivkov V.A. — collection and processing of material; Vshivkov V.A., Anikina K.A. — statistical processing; Polivanova T.V., Anikina K.A. — writing the text; Polivanova T.V. — editing. All co-authors — approval of the final version of the article, responsibility for the integrity of all part of the article.

Acknowledgment

Acknowledgment. The study had no sponsorship.

Conflict of interest

Conflict of interest. The authors declare no conflict of interest.

Received

Received: April 21, 2023Accepted: May 16, 2023Published: June 27, 2023

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The authors declare that there are no conflicts of interest present.