rospedРоссийский педиатрический журнал имени М.Я. СтуденикинаM.Ya. Studenikin Russian Pediatric JournalФГАУ «НМИЦ здоровья детей» Минздрава России10.46563/1560-9561-2024-27-6-446-451mnghbcrosped-1191Research ArticleОБЗОРЫREVIEWSНарушения сна как триггер сердечно-сосудистой патологииSleep disorders as a trigger for cardiovascular pathologyhttps://orcid.org/0000-0002-4121-5900ТихоновскийПавел АндреевичTikhonovskiyPavel A.

Врач функциональной диагностики, ФГАУ «НМИЦ здоровья детей» Минздрава России

e-mail: pasha098@mail.ru

pasha098@mail.ruhttps://orcid.org/0000-0001-8562-6851КожевниковаОльга ВикторовнаKozevnikovaOlga V.

Доктор мед. наук, проф., зав. отделением инструментальной диагностики, гл. науч. сотр. лаб. лучевой и инструментальной диагностики ФГАУ «НМИЦ здоровья детей» Минздрава России

e-mail: olgafd2010@mail.ru

MD, PhD, DSc, prof., head of the Department of instrumental diagnostics, chief researcher at the Laboratory of radiation and instrumental diagnostics, National Medical Research Center for Children’s Health, Moscow, 119991, Russian Federation

e-mail: olgafd2010@mail.ru

olgafd2010@mail.ruhttps://orcid.org/0009-0000-7391-7598БлажиевскаяТамара ОлеговнаBlazhievskayaTamara O.

Врач функциональной диагностики, ФГАУ «НМИЦ здоровья детей» Минздрава России

e-mail: toma.sotnikova@mail.ru

toma.sotnikova@mail.ruhttps://orcid.org/0009-0008-9105-0885КустоваЕлена АлександровнаKustovaElena A.

Врач функциональной диагностики, ФГАУ «НМИЦ здоровья детей» Минздрава России

e-mail: kustovaelena595@gmail.com

kustovaelena595@gmail.comФГАУ «Национальный медицинский исследовательский центр здоровья детей» Минздрава РоссииNational Medical Research Center for Children’s Health202424122024276446451Copyright © Тихоновский П.А., Кожевникова О.В., Блажиевская Т.О., Кустова Е.А., 20242024Тихоновский П.А., Кожевникова О.В., Блажиевская Т.О., Кустова Е.А.Tikhonovskiy P.A., Kozevnikova O.V., Blazhievskaya T.O., Kustova E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rosped.ru/jour/article/view/1191Введение

Введение. Нарушения сна связаны с возникновением и прогрессированием сердечно-сосудистых заболеваний, включая артериальную гипертензию, инсульт, аритмии, ишемическую болезнь сердца и сердечную недостаточность. Однако информированность о распространённости нарушений сна и их влиянии на сопутствующую патологию, включая сердечно-сосудистые заболевания, недостаточная.

Цель обзора — определить значимость раннего выявления нарушений сна для повышения эффективности профилактики сердечно-сосудистых заболеваний.

Проведён поиск литературы по теме: нарушения сна как триггер сердечно-сосудистой патологии. Установлены значимые связи между нарушениями сна и развитием различных форм патологии сердечно-сосудистой системы у взрослых и детей, что обусловливает необходимость своевременного скрининга сна и повышенной осведомлённости врачей.

Участие авторов

Участие авторов: Кожевникова О.В. — концепция и дизайн исследования; Тихоновский П.А., Блажиевская Т.О., Кустова Е.А. — сбор и обработка материала; Кожевникова О.В., Тихоновский П.А. — написание текста, редактирование. Все соавторы — утверждение окончательного варианта статьи, ответственность за целостность всех частей статьи.

Финансирование

Финансирование. Исследование не имело финансовой поддержки.

Конфликт интересов

Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов.

Поступила 21

Поступила 21.11.2024Принята к печати 06.12.2024Опубликована 25.12.2024

Introduction

Introduction. Sleep disorders are associated with the onset and progression of cardiovascular diseases, including hypertension, stroke, arrhythmias, coronary heart disease, and heart failure. However, awareness of the prevalence of sleep disorders and their impact on comorbidities, including cardiovascular diseases, remains insufficient.

The aim of the review

The aim of the review: to determine the importance of early detection of sleep disorders for improving the effectiveness of prevention of cardiovascular diseases. A literature search was conducted on the topic: sleep disorders as a trigger of cardiovascular pathology. Significant links have been established between sleep disorders and the development of various forms of pathology of the cardiovascular system, both in adults and children, which necessitates timely sleep screening.

Conclusion

Conclusion. A certain connection between sleep disorders and cardiovascular diseases necessitates increased awareness in doctors regarding sleep disorders for the prevention of diseases of the cardiovascular system.

Contribution

Contribution: Kozhevnikova O.V. — concept and design of the study; Tikhonovskiy P.A., Blazhievskaya T.O., Kustova E.A. — data collection, processing, writing the text; Kozevnikova O.V. — research concept, editing the text. All co-authors — approval of the final version of the article, responsibility for the integrity of all parts of the article.

Acknowledgment

Acknowledgment. The study had no sponsorship.

Conflict of interest

Conflict of interest. The authors declare no conflict of interest.

Received

Received: November 21, 2024Accepted: December 06, 2024Published: December 25, 2024

обзордетинарушения снаапноэ снасердечно-сосудистые заболеванияартериальная гипертензияаритмииreviewchildrensleep disorderssleep apneacardiovascular diseasesarterial hypertensionarrhythmiasReferencesLv R., Liu X., Zhang Y., Dong N., Wang X., He Y., et al. Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome. Signal Transduct. Target Ther. 2023; 8(1): 218. https://doi.org/ 10.1038/s41392-023-01496-3Lv R., Liu X., Zhang Y., Dong N., Wang X., He Y., et al. Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome. Signal Transduct. Target Ther. 2023; 8(1): 218. https://doi.org/ 10.1038/s41392-023-01496-3Platon A.L., Stelea C.G., Boișteanu O., Patrascanu E., Zetu I.N., Roșu S.N., et al. An update on obstructive sleep apnea syndrome – a literature review. Medicina (Kaunas). 2023; 59(8): 1459. https://doi.org/10.3390/medicina59081459Platon A.L., Stelea C.G., Boișteanu O., Patrascanu E., Zetu I.N., Roșu S.N., et al. An update on obstructive sleep apnea syndrome – a literature review. Medicina (Kaunas). 2023; 59(8): 1459. https://doi.org/10.3390/medicina59081459Baker-Smith C.M., Isaiah A., Melendres M.C., Mahgerefteh J., Lasso-Pirot A., Mayo S., et al. Sleep-disordered breathing and cardiovascular disease in children and adolescents: a scientific statement from the American Heart Association. J. Am. Heart Assoc. 2021; 10(18): e022427. https://doi.org/10.1161/JAHA.121.022427Baker-Smith C.M., Isaiah A., Melendres M.C., Mahgerefteh J., Lasso-Pirot A., Mayo S., et al. Sleep-disordered breathing and cardiovascular disease in children and adolescents: a scientific statement from the American Heart Association. J. Am. Heart Assoc. 2021; 10(18): e022427. https://doi.org/10.1161/JAHA.121.022427Kirk V.G., Edgell H., Joshi H., Constantin E., Katz S.L., MacLean J.E. Cardiovascular changes in children with obstructive sleep apnea and obesity after treatment with noninvasive ventilation. J. Clin. Sleep Med. 2020; 16(12): 2063–71. https://doi.org/10.5664/jcsm.8760Kirk V.G., Edgell H., Joshi H., Constantin E., Katz S.L., MacLean J.E. Cardiovascular changes in children with obstructive sleep apnea and obesity after treatment with noninvasive ventilation. J. Clin. Sleep Med. 2020; 16(12): 2063–71. https://doi.org/10.5664/jcsm.8760Meira E., Cruz M., Salles C., Seixas L.D., Elia C., Rocha I., et al. Comorbid insomnia and sleep apnea in children: a preliminary explorative study. J. Sleep Res. 2023; 32(1): e13705. https://doi.org/10.1111/jsr.13705Meira E., Cruz M., Salles C., Seixas L.D., Elia C., Rocha I., et al. Comorbid insomnia and sleep apnea in children: a preliminary explorative study. J. Sleep Res. 2023; 32(1): e13705. https://doi.org/10.1111/jsr.13705Lechat B., Appleton S., Melaku Y.A., Hansen K., McEvoy R.D., Adams R., et al. The association of co-morbid insomnia and sleep apnea with prevalent cardiovascular disease and incident cardiovascular events. J. Sleep Res. 2022; 31(5): e13563. https://doi.org/10.1111/jsr.13563Lechat B., Appleton S., Melaku Y.A., Hansen K., McEvoy R.D., Adams R., et al. The association of co-morbid insomnia and sleep apnea with prevalent cardiovascular disease and incident cardiovascular events. J. Sleep Res. 2022; 31(5): e13563. https://doi.org/10.1111/jsr.13563Полуэктов М.Г. Диагностика и лечение расстройств сна. М.: МЕДпресс-информ; 2021.Poluektov M.G. Diagnostics and Treatment of Sleep Disorders [Diagnostika i lechenie rasstroistv sna]. Moscow: MEDpress-inform; 2021. (in Russian)Laczay B., Faulx M.D. Obstructive sleep apnea and cardiac arrhythmias: a contemporary review. J. Clin. Med. 2021; 10(17): 3785. https://doi.org/10.3390/jcm10173785Laczay B., Faulx M.D. Obstructive sleep apnea and cardiac arrhythmias: a contemporary review. J. Clin. Med. 2021; 10(17): 3785. https://doi.org/10.3390/jcm10173785Yeghiazarians Y., Jneid H., Tietjens J.R., Redline S., Brown D.L., El-Sherif N., et al. Obstructive sleep apnea and cardiovascular disease: a scientific statement from the American Heart Association. Circulation. 2021; 144(3): e56–e67. https://doi.org/10.1161/CIR.0000000000000988Yeghiazarians Y., Jneid H., Tietjens J.R., Redline S., Brown D.L., El-Sherif N., et al. Obstructive sleep apnea and cardiovascular disease: a scientific statement from the American Heart Association. Circulation. 2021; 144(3): e56–e67. https://doi.org/10.1161/CIR.0000000000000988Jehan S., Myers A.K., Zizi F., Pandi-Perumal S.R., Jean-Louis G., McFarlane S.I. Obesity, obstructive sleep apnea and type 2 diabetes mellitus: Epidemiology and pathophysiologic insights. Sleep Med. Disord. 2018; 2(3): 52–8.Jehan S., Myers A.K., Zizi F., Pandi-Perumal S.R., Jean-Louis G., McFarlane S.I. Obesity, obstructive sleep apnea and type 2 diabetes mellitus: Epidemiology and pathophysiologic insights. Sleep Med. Disord. 2018; 2(3): 52–8.Salman L.A., Shulman R., Cohen J.B. Obstructive sleep apnea, hypertension, and cardiovascular risk: epidemiology, pathophysiology, and management. Curr. Cardiol. Rep. 2020; 22(2): 6. https://doi.org/10.1007/s11886-020-1257-ySalman L.A., Shulman R., Cohen J.B. Obstructive sleep apnea, hypertension, and cardiovascular risk: epidemiology, pathophysiology, and management. Curr. Cardiol. Rep. 2020; 22(2): 6. https://doi.org/10.1007/s11886-020-1257-yTietjens J.R., Claman D., Kezirian E.J., De Marco T., Mirzayan A., Sadroonri B., et al. Obstructive sleep apnea in cardiovascular disease: A review of the literature and proposed multidisciplinary clinical management strategy. J. Am. Heart Assoc. 2019; 8(1): e010440. https://doi.org/10.1161/JAHA.118.010440Tietjens J.R., Claman D., Kezirian E.J., De Marco T., Mirzayan A., Sadroonri B., et al. Obstructive sleep apnea in cardiovascular disease: A review of the literature and proposed multidisciplinary clinical management strategy. J. Am. Heart Assoc. 2019; 8(1): e010440. https://doi.org/10.1161/JAHA.118.010440Ahmed A.M., Nur S.M., Xiaochen Y. Association between obstructive sleep apnea and resistant hypertension: systematic review and meta-analysis. Front. Med. (Lausanne). 2023; 10: 1200952. https://doi.org/10.3389/fmed.2023.1200952Ahmed A.M., Nur S.M., Xiaochen Y. Association between obstructive sleep apnea and resistant hypertension: systematic review and meta-analysis. Front. Med. (Lausanne). 2023; 10: 1200952. https://doi.org/10.3389/fmed.2023.1200952Falla C., Young A., Pope A., O’Driscoll D.M. Obstructive sleep apnea during REM sleep: effects on morning and evening blood pressure. Sleep Med. 2023; 46(3): zsac259. https://doi.org/10.1093/sleep/zsac259Falla C., Young A., Pope A., O’Driscoll D.M. Obstructive sleep apnea during REM sleep: effects on morning and evening blood pressure. Sleep Med. 2023; 46(3): zsac259. https://doi.org/10.1093/sleep/zsac259Kang K.T., Chiu S.N., Lee C.H., Lin M.T., Hsu W.C. Effect of adenotonsillectomy on blood pressure in children with obstructive sleep apnea: a meta-analysis. Sleep Med. 2021; 84: 334–42. https://doi.org/10.1016/j.sleep.2021.06.017Kang K.T., Chiu S.N., Lee C.H., Lin M.T., Hsu W.C. Effect of adenotonsillectomy on blood pressure in children with obstructive sleep apnea: a meta-analysis. Sleep Med. 2021; 84: 334–42. https://doi.org/10.1016/j.sleep.2021.06.017Zhang D., Ma Y., Xu J., Yi F. Association between obstructive sleep apnea (OSA) and atrial fibrillation (AF): A dose-response meta-analysis. Medicine (Baltimore). 2022; 101(30): e29443. https://doi.org/10.1097/MD.0000000000029443Zhang D., Ma Y., Xu J., Yi F. Association between obstructive sleep apnea (OSA) and atrial fibrillation (AF): A dose-response meta-analysis. Medicine (Baltimore). 2022; 101(30): e29443. https://doi.org/10.1097/MD.0000000000029443Moula A.I., Parrini I., Tetta C., Lucà F., Parise G., Rao C.M., et al. Obstructive sleep apnea and atrial fibrillation. J. Clin. Med. 2022; 11(5): 1242. https://doi.org/10.3390/jcm11051242Moula A.I., Parrini I., Tetta C., Lucà F., Parise G., Rao C.M., et al. Obstructive sleep apnea and atrial fibrillation. J. Clin. Med. 2022; 11(5): 1242. https://doi.org/10.3390/jcm11051242Wu T.T., Zou Y.L., Xu K.D., Jiang X.R., Zhou M.M., Zhang S.B., et al. Insomnia and multiple health outcomes: umbrella review of meta-analyses of prospective cohort studies. Public Health. 2023; 215: 66–74. https://doi.org/10.1016/j.puhe.2022.11.021Wu T.T., Zou Y.L., Xu K.D., Jiang X.R., Zhou M.M., Zhang S.B., et al. Insomnia and multiple health outcomes: umbrella review of meta-analyses of prospective cohort studies. Public Health. 2023; 215: 66–74. https://doi.org/10.1016/j.puhe.2022.11.021Kang S.J., Kwon Y.W. Right atrial deformation mechanics in children with adenotonsillar hypertrophy. J. Cardiovasc. Imaging. 2018; 26(4): 201–13. https://doi.org/10.4250/jcvi.2018.26.e26Kang S.J., Kwon Y.W. Right atrial deformation mechanics in children with adenotonsillar hypertrophy. J. Cardiovasc. Imaging. 2018; 26(4): 201–13. https://doi.org/10.4250/jcvi.2018.26.e26Geovanini G.R., Lorenzi-Filho G. Cardiac rhythm disorders in obstructive sleep apnea. J. Thorac. Dis. 2018; 10(Suppl. 34): 4221–30. https://doi.org/10.21037/jtd.2018.12.63Geovanini G.R., Lorenzi-Filho G. Cardiac rhythm disorders in obstructive sleep apnea. J. Thorac. Dis. 2018; 10(Suppl. 34): 4221–30. https://doi.org/10.21037/jtd.2018.12.63Teo Y.H., Han R., Leong S., Teo Y.N., Syn N.L., Wee C.F., et al. Prevalence, types and treatment of bradycardia in obstructive sleep apnea – a systematic review and meta-analysis. Sleep Med. 2022; 89: 104–13. https://doi.org/10.1016/j.sleep.2021.12.003Teo Y.H., Han R., Leong S., Teo Y.N., Syn N.L., Wee C.F., et al. Prevalence, types and treatment of bradycardia in obstructive sleep apnea – a systematic review and meta-analysis. Sleep Med. 2022; 89: 104–13. https://doi.org/10.1016/j.sleep.2021.12.003Sonsuwan N., Houngsuwannakorn K., Chattipakorn N., Sawanyawisuth K. An association between heart rate variability and pediatric obstructive sleep apnea. Ital. J. Pediatr. 2024; 50(1): 54. https://doi.org/10.1186/s13052-024-01576-2Sonsuwan N., Houngsuwannakorn K., Chattipakorn N., Sawanyawisuth K. An association between heart rate variability and pediatric obstructive sleep apnea. Ital. J. Pediatr. 2024; 50(1): 54. https://doi.org/10.1186/s13052-024-01576-2Lee L.A., Chuang H.H., Hsieh H.S., Wang C.Y., Chuang L.P., Li H.Y., et al. Using sleep heart rate variability to investigate the sleep quality in children with obstructive sleep apnea. Front. Public Health. 2023; 11: 1103085. https://doi.org/10.3389/fpubh.2023Lee L.A., Chuang H.H., Hsieh H.S., Wang C.Y., Chuang L.P., Li H.Y., et al. Using sleep heart rate variability to investigate the sleep quality in children with obstructive sleep apnea. Front. Public Health. 2023; 11: 1103085. https://doi.org/10.3389/fpubh.2023Isaiah A., Bertoni D., Pereira K.D., Diaz-Abad M., Mitchell R.B., Das G. Treatment-related changes in heart rate variability in children with sleep apnea. Otolaryngol. Head Neck Surg. 2020; 162(5): 737–45. https://doi.org/ 10.1177/0194599820907882Isaiah A., Bertoni D., Pereira K.D., Diaz-Abad M., Mitchell R.B., Das G. Treatment-related changes in heart rate variability in children with sleep apnea. Otolaryngol. Head Neck Surg. 2020; 162(5): 737–45. https://doi.org/ 10.1177/0194599820907882Kalaydzhiev P., Poroyliev N., Somleva D., Ilieva R., Markov D., Kinova E., et al. Sleep apnea in patients with exacerbated heart failure and overweight. Sleep Med. 2023; 5: 100065. https://doi.org/10.1016/j.sleepx.2023.100065Kalaydzhiev P., Poroyliev N., Somleva D., Ilieva R., Markov D., Kinova E., et al. Sleep apnea in patients with exacerbated heart failure and overweight. Sleep Med. 2023; 5: 100065. https://doi.org/10.1016/j.sleepx.2023.100065Huang B., Huang Y., Zhai M., Zhou Q., Ji S., Liu H., et al. J. Association of sex with cardiovascular outcomes in heart failure patients with obstructive or central sleep apnea. J. Am. Heart Assoc. 20245; 13(5): e031186. https://doi.org/10.1161/JAHA.123.031186Huang B., Huang Y., Zhai M., Zhou Q., Ji S., Liu H., et al. J. Association of sex with cardiovascular outcomes in heart failure patients with obstructive or central sleep apnea. J. Am. Heart Assoc. 20245; 13(5): e031186. https://doi.org/10.1161/JAHA.123.031186Venkataraman S., Karim S., Rajendran A., Chahal C.A.A., Somers V.K. Sleep disordered breathing in hypertrophic cardiomyopathy-current state and future directions. J. Clin. Med. 2020; 9(4): 901. https://doi.org/10.3390/jcm9040901Venkataraman S., Karim S., Rajendran A., Chahal C.A.A., Somers V.K. Sleep disordered breathing in hypertrophic cardiomyopathy-current state and future directions. J. Clin. Med. 2020; 9(4): 901. https://doi.org/10.3390/jcm9040901Лебедев В.В., Кожевникова О.В., Логачева О.С., Ахмедова Э.Э., Филимонова И.К., Басаргина Е.Н. и др. Коморбидность нарушений сна на примере детей с кардиомиопатиями. Вопросы практической педиатрии. 2020; 15(5): 24–33. https://doi.org/10.20953/1817-7646-2020-5-24-33 https://elibrary.ru/wjswyiLebedev V.V., Kozhevnikova O.V., Logacheva O.S., Akhmedova E.E., Filimonova I.K., Basargina E.N., et al. Comorbidity of sleep disorders in children with cardiomyopathies. Voprosy prakticheskoy pediatrii. 2020; 15(5): 24–33. https://doi.org/10.20953/1817-7646-2020-5-24-33 https://elibrary.ru/wjswyi (in Russian)Tong J., Yu Q., Li Y., Du J., Qiu J. Obstructive sleep apnea and cardiovascular events in acute coronary syndrome: a meta-analysis. Coron. Artery. Dis. 2023; 34(3): 177–84. https://doi.org/10.1097/MCA.0000000000001207Tong J., Yu Q., Li Y., Du J., Qiu J. Obstructive sleep apnea and cardiovascular events in acute coronary syndrome: a meta-analysis. Coron. Artery. Dis. 2023; 34(3): 177–84. https://doi.org/10.1097/MCA.0000000000001207Sun H., Du Z., Yu H., Hu C., Du Y., Qin Y. Excessive daytime sleepiness is associated with increased residual cardiovascular risks among coronary artery disease patients with obstructive sleep apnea. Sleep Med. 2024; 115: 131–6. https://doi.org/10.1016/j.sleep.2024.02.004Sun H., Du Z., Yu H., Hu C., Du Y., Qin Y. Excessive daytime sleepiness is associated with increased residual cardiovascular risks among coronary artery disease patients with obstructive sleep apnea. Sleep Med. 2024; 115: 131–6. https://doi.org/10.1016/j.sleep.2024.02.004Sigurdardottir F.D., Bertisch S.M., Reid M.L., deFilippi C.R., Lima J.A.C., Redline S., et al. Association between insomnia phenotypes and subclinical myocardial injury: the multi-ethnic study of atherosclerosis. Sleep. 2023; 46(4): zsac318. https://doi.org/10.1093/sleep/zsac318Sigurdardottir F.D., Bertisch S.M., Reid M.L., deFilippi C.R., Lima J.A.C., Redline S., et al. Association between insomnia phenotypes and subclinical myocardial injury: the multi-ethnic study of atherosclerosis. Sleep. 2023; 46(4): zsac318. https://doi.org/10.1093/sleep/zsac318Hanlon C.E., Binka E., Garofano J.S., Sterni L.M., Brady T.M. The association of obstructive sleep apnea and left ventricular hypertrophy in obese and overweight children with history of elevated blood pressure. J. Clin. Hypertens. (Greenwich). 2019; 21(7): 984–90. https://doi.org/10.1111/jch.13605Hanlon C.E., Binka E., Garofano J.S., Sterni L.M., Brady T.M. The association of obstructive sleep apnea and left ventricular hypertrophy in obese and overweight children with history of elevated blood pressure. J. Clin. Hypertens. (Greenwich). 2019; 21(7): 984–90. https://doi.org/10.1111/jch.13605Gump B.B., Heffernan K.S., Bendinskas K., Hruska B., MacKenzie J.A., Park A., et al. Association of sleep quality with greater left ventricular mass in children aged 9 to 11 years. Psychosom. Med. 2021; 83(3): 265–73. https://doi.org/10.1097/PSY.0000000000000921Gump B.B., Heffernan K.S., Bendinskas K., Hruska B., MacKenzie J.A., Park A., et al. Association of sleep quality with greater left ventricular mass in children aged 9 to 11 years. Psychosom. Med. 2021; 83(3): 265–73. https://doi.org/10.1097/PSY.0000000000000921Pan X.L., Nie L., Zhao S.Y., Zhang X.B., Zhang S., Su Z.F. The association between insomnia and atherosclerosis: a brief report. Nat. Sci. Sleep. 2022; 14: 443–8. https://doi.org/10.2147/NSS.S336318Pan X.L., Nie L., Zhao S.Y., Zhang X.B., Zhang S., Su Z.F. The association between insomnia and atherosclerosis: a brief report. Nat. Sci. Sleep. 2022; 14: 443–8. https://doi.org/10.2147/NSS.S336318Smith D.F., Schuler C.L., Hossain M.M., Huang G., McConnell K., Urbina E.M., et al. Early atherosclerotic inflammatory pathways in children with obstructive sleep apnea. J. Pediatr. 2021; 239: 168–74. https://doi.org/10.1016/j.jpeds.2021.08.031Smith D.F., Schuler C.L., Hossain M.M., Huang G., McConnell K., Urbina E.M., et al. Early atherosclerotic inflammatory pathways in children with obstructive sleep apnea. J. Pediatr. 2021; 239: 168–74. https://doi.org/10.1016/j.jpeds.2021.08.031Kontos A., Willoughby S., Lushington K., Martin J., Wabnitz D., Dorrian J., et al. Increased platelet aggregation in children and adolescents with sleep-disordered breathing. Am. J. Respir. Crit. Care Med. 2020; 202(11): 1560–6. https://doi.org/10.1164/rccm.201911-2229OCKontos A., Willoughby S., Lushington K., Martin J., Wabnitz D., Dorrian J., et al. Increased platelet aggregation in children and adolescents with sleep-disordered breathing. Am. J. Respir. Crit. Care Med. 2020; 202(11): 1560–6. https://doi.org/10.1164/rccm.201911-2229OCMaloney M.A., Ward S.L.D., Su J.A., Durazo-Arvizu R.A., Breunig J.M., Okpara D.U., et al. Prevalence of pulmonary hypertension on echocardiogram in children with severe obstructive sleep apnea. J. Clin. Sleep Med. 2022; 18(6): 1629–37. https://doi.org/10.5664/jcsm.9944Maloney M.A., Ward S.L.D., Su J.A., Durazo-Arvizu R.A., Breunig J.M., Okpara D.U., et al. Prevalence of pulmonary hypertension on echocardiogram in children with severe obstructive sleep apnea. J. Clin. Sleep Med. 2022; 18(6): 1629–37. https://doi.org/10.5664/jcsm.9944Burns A.T., Hansen S.L., Turner Z.S., Aden J.K., Black A.B., Hsu D.P. Prevalence of pulmonary hypertension in pediatric patients with obstructive sleep apnea and a cardiology evaluation: a retrospective analysis. J. Clin. Sleep Med. 2019; 15(8): 1081–7. https://doi.org/10.5664/jcsm.7794Burns A.T., Hansen S.L., Turner Z.S., Aden J.K., Black A.B., Hsu D.P. Prevalence of pulmonary hypertension in pediatric patients with obstructive sleep apnea and a cardiology evaluation: a retrospective analysis. J. Clin. Sleep Med. 2019; 15(8): 1081–7. https://doi.org/10.5664/jcsm.7794Bhat S., Chokroverty S. Sleep disorders and COVID-19. Sleep Med. 2022; 91: 253–61. https://doi.org/10.1016/j.sleep.2021.07.021Bhat S., Chokroverty S. Sleep disorders and COVID-19. Sleep Med. 2022; 91: 253–61. https://doi.org/10.1016/j.sleep.2021.07.021Veazie S., Lafavor B., Vela K., Young S., Sayer N.A., Carlson K.F., et al. Mental health outcomes of adults hospitalized for COVID-19: A systematic review. J. Affect. Disord. Rep. 2022; 8: 100312. https://doi.org/10.1016/j.jadr.2022.100312Veazie S., Lafavor B., Vela K., Young S., Sayer N.A., Carlson K.F., et al. Mental health outcomes of adults hospitalized for COVID-19: A systematic review. J. Affect. Disord. Rep. 2022; 8: 100312. https://doi.org/10.1016/j.jadr.2022.100312Арутюнов Г.П., Тарловская Е.И., Арутюнов А.Г., Поляков Д.С., Беленков Ю.Н., Конради А.О. и др. Вновь диагностированные заболевания и частота их возникновения у пациентов после новой коронавирусной инфекции. Российский кардиологический журнал. 2023; 28(4): 5424. https://doi.org/10.15829/1560-4071-2023-5424 https://elibrary.ru/tpvhtpArutyunov G.P., Tarlovskaya E.I., Arutyunov A.G., Polyakov D.S., Belenkov Y.N., Konradi A.O., et al. Newly diagnosed diseases and the frequency of their occurrence in patients after a new coronavirus infection. Results of an international register “dynamics analysis of comorbidities in Sars-CoV-2 survivors (activ SARS-CoV-2)” (12-month follow-up). Rossiiskiy kardiologicheskiy zhurnal. 2023; 28(4): 5424. https://doi.org/10.15829/1560-4071-2023-5424 https://elibrary.ru/tpvhtp (in Russian)Sameema V.V., Soni K., Deora S., Sharma J.B., Choudhury B., Kaushal D., et al. Assessment of preoperative and postoperative cardiac function in children with adenotonsillar hypertrophy: a prospective cohort study. Eur. Arch. Otorhinolaryngol. 2022; 279(6): 3013–9. https://doi.org/10.1007/s00405-022-07255-4Sameema V.V., Soni K., Deora S., Sharma J.B., Choudhury B., Kaushal D., et al. Assessment of preoperative and postoperative cardiac function in children with adenotonsillar hypertrophy: a prospective cohort study. Eur. Arch. Otorhinolaryngol. 2022; 279(6): 3013–9. https://doi.org/10.1007/s00405-022-07255-4Hawkins S., Huston S., Campbell K., Halbower A. High-flow, heated, humidified air via nasal cannula treats CPAP-intolerant children with obstructive sleep apnea. J. Clin. Sleep Med. 2017; 13(8): 981–9. https://doi.org/10.5664/jcsm.6700Hawkins S., Huston S., Campbell K., Halbower A. High-flow, heated, humidified air via nasal cannula treats CPAP-intolerant children with obstructive sleep apnea. J. Clin. Sleep Med. 2017; 13(8): 981–9. https://doi.org/10.5664/jcsm.6700Seidel M., Kiziler M.F., Matiakis M., Bertram S., Wang S., Seibert F.S., et al. Predictors of blood pressure response to continuous positive airway pressure treatment in patients with sleep apnea. J. Hypertens. 2024; 42(5): 777–82. https://doi.org/10.1097/HJH.0000000000003694Seidel M., Kiziler M.F., Matiakis M., Bertram S., Wang S., Seibert F.S., et al. Predictors of blood pressure response to continuous positive airway pressure treatment in patients with sleep apnea. J. Hypertens. 2024; 42(5): 777–82. https://doi.org/10.1097/HJH.0000000000003694Affas Z., Affas S., Tabbaa K. Continuous positive airway pressure reduces the incidence of atrial fibrillation in patients with obstructive sleep apnea: a meta-analysis and systematic review. Spartan Med. Res. J. 2022; 7(2): 34521. https://doi.org/10.51894/001c.34521Affas Z., Affas S., Tabbaa K. Continuous positive airway pressure reduces the incidence of atrial fibrillation in patients with obstructive sleep apnea: a meta-analysis and systematic review. Spartan Med. Res. J. 2022; 7(2): 34521. https://doi.org/10.51894/001c.34521

The authors declare that there are no conflicts of interest present.