rospedРоссийский педиатрический журнал имени М.Я. СтуденикинаM.Ya. Studenikin Russian Pediatric JournalФГАУ «НМИЦ здоровья детей» Минздрава России10.46563/1560-9561-2025-28-3-223-230wkesvrrosped-1653Research ArticleОБЗОРЫREVIEWSХроническая сердечная недостаточность у детей: этиология, патогенез, клиника и диагностикаChronic heart failure in children: etiology, pathogenesis, clinical picture and diagnosishttps://orcid.org/0000-0002-0144-2885БасаргинаЕлена НиколаевнаBasarginaElena N.

Доктор мед. наук, проф., гл. науч. сотр. лаб. разработки новых технологий диагностики и лечения болезней детского возраста, зав. кардиологическим отделением ФГАУ «НМИЦ здоровья детей» Минздрава России

e-mail: basargina@nczd.ru

MD, PhD, DSc, prof., Head of the Cardiology department, National Medical Research Center for Children’s Health, Moscow, 119991, Russian Federation

e-mail: basargina@nczd.ru

basargina@nczd.ruhttps://orcid.org/0000-0001-7336-4102ВасичкинаЕлена СергеевнаVasichkinaElena S.

Доктор мед. наук, зав. НИЦ неизвестных, редких и генетически обусловленных заболеваний, проф. каф. детских болезней ФГБУ «НМИЦ им. В.А. Алмазова» Минздрава России

e-mail: vasichkinalena@mail.ru

vasichkinalena@mail.ruhttps://orcid.org/0000-0003-4221-8406ЖароваОльга ПавловнаZharovaOlga P.

Канд. мед. наук, врач – детский кардиолог кардиологического отделения ФГАУ «НМИЦ здоровья детей» Минздрава России

e-mail: zharova@nczd.ru

zharova@nczd.ruhttps://orcid.org/0000-0001-8195-5682КовалевИгорь АлександровичKovalevIgor A.

Доктор мед. наук, проф., зам. директора по лечебной работе, зав. отделом детской кардиологии и аритмологии «НИКИ педиатрии и детской хирургии им. акад. Ю.Е. Вельтищева» ФГАОУ ВО «РНИМУ им. Н.И. Пирогова» Минздрава России

e-mail: igor.kovalev64@mail.ru

igor.kovalev64@mail.ruhttps://orcid.org/0000-0002-5819-9046КолосковаНадежда НиколаевнаKoloskovaNataliya N.

Доктор мед. наук, проф., зав. кардиологическим отделением ФГБУ «НМИЦ трансплантологии и искусственных органов им. акад. В.И. Шумакова» Минздрава России

e-mail: nkrasotka@mail.ru

nkrasotka@mail.ruhttps://orcid.org/0000-0001-6776-2614КотлуковаНаталья ПавловнаKotlukovaNataliya P.

Доктор мед. наук, проф. каф. госпитальной педиатрии № 1 педиатрического факультета ГБОУ ВПО «РНИМУ им. Н.И. Пирогова» Минздрава России; педиатрический факультет, каф. госпитальной педиатрии им. акад. В.А. Таболина, ФГАОУ ВО «РНИМУ им. Н.И. Пирогова» Минздрава России

e-mail: natali130@yandex.ru

natali130@yandex.ruhttps://orcid.org/0000-0002-5273-6859ЛеонтьеваИрина ВикторовнаLeontyevaIrina V.

Доктор мед. наук, проф., гл. науч. сотр. отдела детской кардиологии и аритмологии НИКИ педиатрии им. акад. Ю.Е. Вельтищева ФГАОУ ВО «РНИМУ им. Н.И. Пирогова» Минздрава России

e-mail: lirina2006@mail.ru

lirina2006@mail.ruhttps://orcid.org/0000-0002-7514-2260ПервунинаТатьяна МихайловнаPervuninaTatyana M.

Доктор мед. наук, директор Института перинатологии и педиатрии, ФГБУ «НМИЦ им. В.А. Алмазова» Минздрава России

e-mail: ptm.pervunina@yandex.ru

ptm.pervunina@yandex.ruhttps://orcid.org/0000-0002-0548-5639РябцевДмитрий ВадимовичRyabtsevDmitrij V.

Канд. мед. наук, зав. кардиохирургическим отделением № 2 ФГБУ «НМИЦ трансплантологии и искусственных органов им. акад. В.И. Шумакова» Минздрава России

e-mail: dvryabtsev@gmail.com

dvryabtsev@gmail.comhttps://orcid.org/0009-0001-6367-6185СильноваИрина ВячеславовнаSilnovaIrina V.

Канд. мед. наук, врач ультразвуковой диагностики ФГАУ «НМИЦ здоровья детей» Минздрава России

e-mail: silnova.iv@nczd.ru

silnova.iv@nczd.ruhttps://orcid.org/0000-0001-9627-2833ТрунинаИнна ИгоревнаTruninaInna I.

Доктор мед. наук, проф. каф. госпитальной педиатрии № 1 педиатрического факультета ГБОУ ВПО «РНИМУ им. Н.И. Пирогова» Минздрава России; проф., гл. внештатный детский кардиолог; зав. отд. кардиологии ГБУЗ «ДГКБ им. З.А. Башляевой ДЗМ», Москва

e-mail: itrunina@mail.ru

itrunina@mail.ruФГАУ «Национальный медицинский исследовательский центр здоровья детей» Минздрава РоссииNational Medical Research Center for Children’s HealthФГБУ «Национальный медицинский исследовательский центр им. В.А. Алмазова» Минздрава РоссииV.A. Almazov Center Department of Children’s DiseasesФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииN.I. Pirogov Russian National Research Medical UniversityФГБУ «НМИЦ трансплантологии и искусственных органов им. акад. В.И. Шумакова» Минздрава РоссииShumakov National Medical Research Center of Transplantology and Artificial OrgansФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России; ГБУЗ «Детская городская клиническая больница им. З.А. Башляевой» ДЗМN.I. Pirogov Russian National Research Medical University; Z.A. Bashlyaeva Children City Clinical Hospital, Department of health of Moscow202520072025283223230Copyright © Басаргина Е.Н., Васичкина Е.С., Жарова О.П., Ковалев И.А., Колоскова Н.Н., Котлукова Н.П., Леонтьева И.В., Первунина Т.М., Рябцев Д.В., Сильнова И.В., Трунина И.И., 20252025Басаргина Е.Н., Васичкина Е.С., Жарова О.П., Ковалев И.А., Колоскова Н.Н., Котлукова Н.П., Леонтьева И.В., Первунина Т.М., Рябцев Д.В., Сильнова И.В., Трунина И.И.Basargina E.N., Vasichkina E.S., Zharova O.P., Kovalev I.A., Koloskova N.N., Kotlukova N.P., Leontyeva I.V., Pervunina T.M., Ryabtsev D.V., Silnova I.V., Trunina I.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rosped.ru/jour/article/view/1653

Хроническая сердечная недостаточность (ХСН) является грозным осложнением заболеваний сердечно-сосудистой системы или её поражений при других формах патологии и характеризуется значительным риском инвалидизации и смертности. В основе прогрессирования ХСН любой этиологии лежит ремоделирование сердечно-сосудистой системы, связанное с активацией нейрогормональных систем: симпатико-адреналовой (САС) и ренин-ангиотензин-альдостероновой (РААС). Цель обзора: представить современные концепции этиологии, патогенеза, диагностики и клинической картины ХСН у детей для оптимизации клинического ведения больных и расширения объёма знаний практикующих врачей. Современным фармакологическим методом лечения, влияющим на прогноз, предупреждающим прогрессирование поражения миокарда, является модулирование активности САС и РААС на циркуляторном, тканевом и клеточном уровнях. При определении тактики лечения детей следует установить этиологию ХСН, идентифицировать сопутствующие формы патологии, определить варианты и степень выраженности дисфункции миокарда, оценить тяжесть клинических проявлений.

Участие авторов

Участие авторов: Басаргина Е.Н. — концепция и дизайн исследования; Васичкина Е.С., Жарова О.П., Ковалев И.А., Колоскова Н.Н., Котлукова Н.П., Леонтьева И.В., Первунина Т.М., Рябцев Д.В., Сильнова И.В., Трунина И.И. — сбор и обработка материала; Басаргина Е.Н., Котлукова Н.П., Жарова О.П., Трунина И.И. — написание текста; Басаргина Е.Н., Васичкина Е.С., Ковалев И.А. — редактирование. Все соавторы — утверждение окончательного варианта статьи, ответственность за целостность всех частей статьи.

Финансирование

Финансирование. Исследование не имело финансовой поддержки.

Конфликт интересов

Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов.

Поступила 23

Поступила 23.04.2025Принята к печати 20.05.2025Опубликована 27.06.2025

Introduction

Introduction. Chronic heart failure (CHF) is a threatening complication of cardiovascular diseases or damage in other pathological processes. CHF is characterized by a significant risk of disability and mortality in childhood. The progression of CHF of any etiology is based on the process of cardiovascular remodeling associated with the activation of neurohormonal systems, sympathicoadrenal and renin-angiotensin-aldosterone. Aim of the review: to highlight the issues of the modern view of the etiology, pathogenesis, diagnosis and clinical features in CHF children to increase the knowledge in practitioners for better management of patients. A modern pharmacological treatment method that affects the prognosis and prevents the progression of myocardial damage is based on modulation of the activity of sympathicoadrenal and renin-angiotensin-aldosterone systems at the circulating, tissue, and cellular levels. When determining the treatment of children, the etiology of CHF should be established, concomitant diseases should be identified, the variant and severity of myocardial dysfunction should be determined, and the severity of clinical manifestations should be assessed.

Contribution

Contribution: Basargina E.N. — concept and design of the study; Basargina E.N., Vasichkina E.S., Zharova O.P., Kovalev I.A., Kotlukova N.P., Trunina I.I. — collection and processing of material; Basargina E.N., Zharova O.P. — writing the text; Vasichkina E.S., Kovalev I.A., Koloskova N.N., Kotlukova N.P., Leontyeva I.V., Pervunina T.M., Ryabtsev D.V., Silnova I.V., Trunina I.I. — editing the text. All co-authors — approval of the final version of the article, responsibility for the integrity of all parts of the article.

Acknowledgment

Acknowledgment. The study had no sponsorship.

Conflict of interest

Conflict of interest. The authors declare no conflict of interest.

Received

Received: April 23, 2025Accepted: May 20, 2025Published: June 27, 2025

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The authors declare that there are no conflicts of interest present.