rospedРоссийский педиатрический журнал имени М.Я. СтуденикинаM.Ya. Studenikin Russian Pediatric JournalФГАУ «НМИЦ здоровья детей» Минздрава России10.46563/1560-9561-2023-26-2-102-106tgqaorrosped-18Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL INVESTIGATIONSПерекрёст некоторых форм функциональной патологии органов пищеварения у детейOverlap of some forms of functional pathology of organs of digestion in childrenhttps://orcid.org/0000-0002-0014-2581ЛатышевДмитрий ЮрьевичLatyshevDmitry Y.

Канд. мед. наук, доцент каф. пропедевтики детских болезней ФГБОУ ВО АГМУ Минздрава России

e-mail: ldy2014@mail.ru

MD, PhD, Associate Professor, Department of propaedeutics of children’s diseases, Altai State Medical University, Barnaul, 656038, Russian Federation

e-mail: ldy2014@mail.ru

ldy2014@mail.ruhttps://orcid.org/0000-0001-6284-1604ЛобановЮрий ФедоровичLobanovYuri F.

Доктор мед. наук, проф., зав. каф. пропедевтики детских болезней ФГБОУ ВО АГМУ Минздрава России

e-mail: ped2@agmu.ru

ped2@agmu.ruhttps://orcid.org/0000-0002-8586-1330СтрозенкоЛюдмила АнатольевнаStrozenkoLudmila A.

Доктор мед. наук, проф. каф. пропедевтики детских болезней ФГБОУ ВО АГМУ Минздрава России

e-mail: strozen@mail.ru

strozen@mail.ruhttps://orcid.org/0000-0002-5170-3852РимерНаталья КонстантиновнаRiemerNatalia K.

Канд. мед. наук, доцент каф. пропедевтики детских болезней ФГБОУ ВО АГМУ Минздрава России

e-mail: bish­_natasha@list.ru

bish_natasha@list.ruФГБОУ ВО «Алтайский государственный медицинский университет» Минздрава РоссииРоссияAltai State Medical University of the Ministry of Health of RussiaRussian Federation202309082023232102106Copyright © Латышев Д.Ю., Лобанов Ю.Ф., Строзенко Л.А., Ример Н.К., 20232023Латышев Д.Ю., Лобанов Ю.Ф., Строзенко Л.А., Ример Н.К.Latyshev D.Y., Lobanov Y.F., Strozenko L.A., Riemer N.K.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rosped.ru/jour/article/view/18Введение

Введение. Частота перекрёста между гастроэзофагеальной рефлюксной болезнью (ГЭРБ) и синдромом раздражённого кишечника (СРК) у взрослых больных может составлять 3–79%. Существуют лишь единичные работы о перекрёсте между функциональной диспепсией и СРК кишечника, между ГЭРБ и функциональным запором у детей.

Цель работы — определить частоту синдрома перекрёста ГЭРБ с СРК и функциональной диспепсией у детей школьного возраста.

Материалы и методы

Материалы и методы. Обследовано 98 детей (71 мальчик и 27 девочек) в возрасте 7–17 лет (средний возраст 11,4 ± 2,1 года) с эрозивной формой ГЭРБ — основная группа. Группу сравнения составили 30 детей (11 мальчиков и 19 девочек) с неэрозивной ГЭРБ (средний возраст 12,7 ± 1,8 года). Критериями включения в основную группу было наличие эрозивных изменений в пищеводе, в группу сравнения — наличие изжоги не реже 2 раз в неделю за последние 3 мес и отсутствие эрозивных изменений в пищеводе. Критерий исключения — наличие органической патологии со стороны верхних (язвенная болезнь и др.) и нижних отделов пищеварительного тракта (язвенный колит, болезнь Крона и др.).

Результаты

Результаты. У 25,8% больных с ГЭРБ отмечается перекрёст с функциональными заболеваниями кишечника, при этом несколько чаще выявляются сочетания ГЭРБ с СРК с диареей (15,6%), чем СРК с запорами/функциональным запором (10,2%). Значительно реже отмечается перекрёст СРК с постпрандиальным дистресс-синдромом — только у 7% детей. 

Заключение

Заключение. Для детей школьного возраста с ГЭРБ характерен частый перекрёст с функциональными заболеваниями кишечника. Сочетание всех трех заболеваний (СРК, ГЭРБ и постпрандиального дистресс-синдрома) отмечено в 2,3% случаев. Данные закономерности характерны для больных как с эрозивной, так и с неэрозивной формами ГЭРБ.

Участие авторов

Участие авторов:Латышев Д.Ю. — концепция и дизайн исследования; Латышев Д.Ю., Ример Н.К. — сбор и обработка материала; Латышев Д.Ю., Строзенко Л.А. — статистическая обработка материала;Латышев Д.Ю., Лобанов Ю.Ф. — написание текста;Строзенко Л.А., Лобанов Ю.Ф. — редактирование.Все соавторы — утверждение окончательного варианта статьи, ответственность за целостность всех частей статьи.

Финансирование

Финансирование. Исследование не имело финансовой поддержки.

Конфликт интересов

Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов. 

Поступила 10

Поступила 10.02.2023Принята к печати 21.03.2023Опубликована 28.04.2023

Introduction

Introduction. In the adult population, a high prevalence of the gastroesophageal reflux disease (GERD) and irritable bowel syndrome (IBS) can vary from 3 to 79%. As for children, there are a few works on the overlap between functional dyspepsia and IBS, GERD and functional constipation.

Aim

Aim. To determine the prevalence of overlap of the GERD syndrome with irritable bowel syndrome and functional dyspepsia in school-age children.

Materials and methods

Materials and methods. The study included ninety eight cases including 71 boy and 27 girls, aged of 7 to 17 years (mean age 11.4 ± 2.1 years) suffered from erosive GERD. The comparison group consisted of 30 patients (11 boys and 19 girls), of mean age of 12.7 ± 1.8 years without erosive GERD). The criterion for inclusion in the main group was the presence of erosive changes in the esophagus according to fibrogastroduodenoscopy, in the comparison group the — manifestation of heartburn, with occurrence, at least twice a week over the past three months and the absence of erosive changes in the esophagus according to fibrogastroduodenoscopy. The exclusion criterion was the presence of organic pathology with sides of the upper (peptic ulcer, etc.) and lower parts of the digestive tract (ulcerative colitis, Crohn’s disease, etc.).

Results

Results. Every fourth GERD patient (25.8%) has an overlap with functional bowel diseases, while GERD is more often combined with IBS with diarrhea (15.6%) than IBS with constipation/functional constipation (10.2%). Overlap of IBS with postprandial distress syndrome is much less common — only in 7.0% of children.

Conclusion

Conclusion. School-age GERD children are characterized by frequent overlap with functional bowel diseases, the frequency of which reaches 25.8%. The combination of all three diseases (IBS, GERD and postprandial distress syndrome) was observed in 2.3% of cases. These patterns are typical for patients with both erosive and non-erosive forms of GERD.

Contribution

Contribution:Latyshev D.Yu. — concept and design of the study; Latyshev D.Yu., Rimer N.K. — collection and processing of material; Latyshev D.Yu., Strozenko L.A. — statistical processing of the material; Latyshev D.Yu., Lobanov Yu.F. — writing the text;Strozenko L.A., Lobanov Yu.F. — editing.All co-authors — approval of the final version of the article, responsibility for the integrity of all parts of the article.

Acknowledgment

Acknowledgment. The study had no sponsorship.

Conflict of interest

Conflict of interest. The authors declare no conflict of interest.

Received

Received: February 10, 2023Accepted: March 21, 2023Published: April 28, 2023

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The authors declare that there are no conflicts of interest present.