rospedРоссийский педиатрический журнал имени М.Я. СтуденикинаM.Ya. Studenikin Russian Pediatric Journal3033-90063033-9014ФГАУ «НМИЦ здоровья детей» Минздрава России10.46563/2026-1-1-53-60rosped-2032Research ArticleНАУЧНЫЕ ОБЗОРЫREVIEWSСовременные подходы к диагностике и лечению синдрома поликистозных яичников у девочек-подростковModern approaches to the diagnosis and treatment of polycystic ovary syndrome in adolescent girlshttps://orcid.org/0000-0002-4540-6341СибирскаяЕ. В.SibirskayaElena V.

Сибирская Елена Викторовна, доктор мед. наук, проф. каф. акушерства, гинекологии и репродуктивной медицины; зав. гинекологическим отд-м; доктор мед. наук, проф. каф. акушерства и гинекологии им. акад. Г.М. Савельевой педиатрического факультета

e-mail: elsibirskaya@yandex.ru

Elena V. Sibirskaya, MD, PhD, DSci, prof., Department of Obstetrics, Gynecology and Reproductive Medicine; Head, Gynecological department; prof., Department of obstetrics and gynecology named after Academician G.M. Savelyeva, Pediatric Faculty

e-mail: elsibirskaya@yandex.ru

elsibirskaya@yandex.ruhttps://orcid.org/0000-0001-8579-2227ШарковС. М.SharkovSergey M.

Шарков Михаил Сергеевич, доктор мед. наук, проф., руководитель городского Центра репродуктивного здоровья детей и подростков

e-mail: sharkdoc@mail.ru

sharkdoc@mail.ruhttps://orcid.org/0009-0006-6361-4933КарапетянА. А.KarapetyanAni A.

Карапетян Ани Арменовна, студентка 5-го курса лечебного факультета

https://orcid.org/0009-0009-8744-634XЧатикянИ. А.ChatikyanIveta A.

Чатикян Ивета Акоповна, студент­ ка 5-го курса лечебного факультета

ФГБОУ ВО «Российский университет медицины» Минздрава России; Российская детская клиническая больница — филиал ФГБОУ ВО «РНИМУ им. Н.И. Пирогова» Минздрава России (Пироговский Университет); ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России (Пироговский Университет)РоссияRussian University of Medicine; Russian Children’s Clinical Hospital — a branch of the Pirogov Russian National Research Medical University (Pirogov University); Pirogov Russian National Research Medical University (Pirogov University)Russian FederationГБУЗ «Морозовская детская городская клиническая больница» Департамента здравоохранения г. Москвы; ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России (Пироговский Университет)РоссияMorozov Children’s Municipal Clinical Hospital; Pirogov Russian National Research Medical University (Pirogov University)Russian FederationФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России (Пироговский Университет)РоссияPirogov Russian National Research Medical University (Pirogov University)Russian Federation202627032026115360Copyright © Сибирская Е.В., Шарков С.М., Карапетян А.А., Чатикян И.А., 20262026Сибирская Е.В., Шарков С.М., Карапетян А.А., Чатикян И.А.Sibirskaya E.V., Sharkov S.M., Karapetyan A.A., Chatikyan I.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rosped.ru/jour/article/view/2032Введение

Введение. Синдром поликистозных яичников (СПКЯ) — значимое эндокринное нарушение, особенно затруднительное для диагностики у девочек-подростков, когда его клиническая картина камуфлируется под физиологические особенности пубертатного периода. Ключевыми клиническими проявлениями СПКЯ у подростков являются нарушения менструального цикла, гиперандрогенные симптомы и метаболические изменения, которые в совокупности создают высокий риск неблагоприятных репродуктивных и соматических последствий. Цель обзора: представить современные данные о формировании СПКЯ, его патогенезе, диагностике и лечении у девочек-подростков. Поиск литературы проводили в базах данных PubMed, eLIBRARY.RU, Google Scholar, Embase. Отсутствие универсальных диагностических критериев СПКЯ приводит к его гиперили гиподиагностике. Диагностический процесс у девочек-подростков требует особой осторожности и динамического подхода. Значимыми диагностическими критериями являются стойкие нарушения менструального цикла в сочетании с клиническими и лабораторными признаками гиперандрогении. Лечение СПКЯ у девочек-подростков должно быть комплексным и включать модификацию образа жизни, медикаментозные и при необходимости альтернативные подходы. Использование комбинированных оральных контрацептивов, метформина и антиандрогенных препаратов проводится с учётом индивидуальных особенностей больных и под строгим контролем безопасности. Важное значение имеют образовательные и психоэмоциональные программы, направленные на повышение приверженности лечению и снижение негативного влияния заболевания на качество жизни. Своевременное выявление и лечение СПКЯ у подростков играет значимую роль в профилактике серьёзных репродуктивных и метаболических осложнений в последующей жизни, что делает создание оптимальных подходов к ранней диагностике и терапии СПКЯ первоочередной и важной задачей.Участие авторов: Сибирская Е.В. — концепция и дизайн; Карапетян А.А., Чатикян И.А. — cбор и обработка информации; Сибирская Е.В., Карапетян А.А., Чатикян И.А. —написание текста; Шарков С.М. — редактирование. Все соавторы — утверждение окончательного варианта статьи, ответственность за целостность всех частей статьи.Финансирование. Исследование не имело финансовой поддержки.Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов.

Поступила 20

Поступила 20.01.2026Принята к печати 10.02.2026Опубликована 27.02.2026

Introduction

Introduction. Polycystic ovarian syndrome (PCOS) is a significant endocrine disorder that is especially difficult to diagnose in adolescent girls when its clinical picture is disguised as the physiological features of puberty. The key clinical manifestations of PCOS in adolescents are menstrual disorders, hyperandrogenic symptoms, and metabolic changes, which together create a high risk of adverse reproductive and somatic consequences in the future. The aim of the review is to present up-to-date data on the formation of PCOS, its pathogenesis, diagnosis, and treatment in adolescent girls. The literature was searched in the databases PubMed, eLibrary, Google Scholar, Embase. The lack of universal diagnostic criteria for PCOS leads to its overdiagnosis or underdiagnosis. The diagnostic process in adolescent girls requires special care and a dynamic approach. Significant diagnostic criteria are persistent menstrual irregularities in combination with clinical and laboratory signs of hyperandrogenism. Treatment of PCOS in adolescent girls should be comprehensive and include lifestyle modification, medication, and, if necessary, alternative approaches. The use of combined oral contraceptives, metformin and antiandrogenic drugs is carried out taking into account the individual characteristics of patients and under strict safety control. Educational and psycho-emotional programs aimed at increasing adherence to treatment and reducing the adverse impact of the disease on the quality of life are important. Timely detection and treatment of PCOS in adolescents plays an important role in the prevention of serious reproductive and metabolic complications in later life, which makes the creation of optimal approaches to early diagnosis and therapy of PCOS a priority and important task.Contribution: Sibirskaya E.V. — concept and design; Karapetyan A.A., Chatikyan I.A. — information collection and processing; Sibirskaya E.V., Karapetyan A.A., Chatikyan I.A. —writing the text; Sharkov S.M. — editing the text. All co-authors — approval of the final version of the article, responsibility for the integrity of all parts of the article.Acknowledgments. The study had no sponsorship.Conflict of interest. The authors declare no conflict of interest.

Received

Received: January 20, 2026Accepted: February 10, 2026Published: February 27, 2026

обзордетисиндром поликистозных яичниковэндокринные нарушениярепродуктивное здоровьепубертатный периодreviewchildrenpolycystic ovary syndromeendocrine disordersreproductive healthpubertyReferencesWitchel S.F., Azziz R., Oberfield S.E. History of polycystic ovary syndrome, premature adrenarche, and hyperandrogenism in pediatric endocrinology. Horm. Res. Paediatr. 2022; 95(6): 557–67. https://doi.org/10.1159/000526722Witchel S.F., Azziz R., Oberfield S.E. History of polycystic ovary syndrome, premature adrenarche, and hyperandrogenism in pediatric endocrinology. Horm. Res. Paediatr. 2022; 95(6): 557–67. https://doi.org/10.1159/000526722Saleh F.L., Starkman H., Furness A., Pfeifer S.M., Kives S. Polycystic ovary syndrome in adolescents. Obstet. Gynecol. Clin. North Am. 2024; 51(4): 679–93. https://doi.org/10.1016/j.ogc.2024.08.005Saleh F.L., Starkman H., Furness A., Pfeifer S.M., Kives S. Polycystic ovary syndrome in adolescents. Obstet. Gynecol. Clin. North Am. 2024; 51(4): 679–93. https://doi.org/10.1016/j.ogc.2024.08.005Azziz R., Carmina E., Chen Z., Dunaif A., Laven J.S., Legro R.S., et al. Polycystic ovary syndrome. Nat. Rev. Dis. Primers. 2016; 2: 16057. https://doi.org/10.1038/nrdp.2016.57Azziz R., Carmina E., Chen Z., Dunaif A., Laven J.S., Legro R.S., et al. Polycystic ovary syndrome. Nat. Rev. Dis. Primers. 2016; 2: 16057. https://doi.org/10.1038/nrdp.2016.57Neven A.C.H., Forslund M., Ranashinha S., Mousa A., Tay C.T., Peña A., et al. Prevalence and accurate diagnosis of polycystic ovary syndrome in adolescents across world regions: a systematic review and meta-analysis. Eur. J. Endocrinol. 2024; 191(4): S15–27. https://doi.org/10.1093/ejendo/lvae125Neven A.C.H., Forslund M., Ranashinha S., Mousa A., Tay C.T., Peña A., et al. Prevalence and accurate diagnosis of polycystic ovary syndrome in adolescents across world regions: a systematic review and meta-analysis. Eur. J. Endocrinol. 2024; 191(4): S15–27. https://doi.org/10.1093/ejendo/lvae125Amiri M., Hatoum S., Buyalos R.P., Sheidaei A., Azziz R. The influence of study quality, age, and geographic factors on PCOS prevalence-a systematic review and meta-analysis. J. Clin. Endocrinol. Metab. 2025; 110(7): 2082–103. https://doi.org/10.1210/clinem/dgae917Amiri M., Hatoum S., Buyalos R.P., Sheidaei A., Azziz R. The influence of study quality, age, and geographic factors on PCOS prevalence-a systematic review and meta-analysis. J. Clin. Endocrinol. Metab. 2025; 110(7): 2082–103. https://doi.org/10.1210/clinem/dgae917Peña A.S., Witchel S.F., Boivin J., Burgert T.S., Ee C., Hoeger K.M., et al. International evidence-based recommendations for polycystic ovary syndrome in adolescents. BMC Med. 2025; 23(1): 151. https://doi.org/10.1186/s12916-025-03901-wPeña A.S., Witchel S.F., Boivin J., Burgert T.S., Ee C., Hoeger K.M., et al. International evidence-based recommendations for polycystic ovary syndrome in adolescents. BMC Med. 2025; 23(1): 151. https://doi.org/10.1186/s12916-025-03901-wTfayli H., Arslanian S., Witchel S.F. Polycystic ovary syndrome: origins and implications: PCOS in adolescents: ontogeny of neuroendocrine and metabolic disturbances. Reproduction. 2025; 170(6): e250115. https://doi.org/10.1530/REP-25-0115Tfayli H., Arslanian S., Witchel S.F. Polycystic ovary syndrome: origins and implications: PCOS in adolescents: ontogeny of neuroendocrine and metabolic disturbances. Reproduction. 2025; 170(6): e250115. https://doi.org/10.1530/REP-25-0115Zhang Y., Yang K., Fan T., Zheng D., Liu H. Diagnosis and Treatment of Adolescent Polycystic Ovary syndrome: A Review. Int. J. Womens Health. 2025; 17: 459–74. https://doi.org/10.2147/IJWH.S506498Zhang Y., Yang K., Fan T., Zheng D., Liu H. Diagnosis and Treatment of Adolescent Polycystic Ovary syndrome: A Review. Int. J. Womens Health. 2025; 17: 459–74. https://doi.org/10.2147/IJWH.S506498Capozzi A., Vignali M., Scambia G., Lello S. Pathophysiology and diagnostic criteria of PCOS. Minerva Obstet. Gynecol. 2025; 77(5): 361–72. https://doi.org/10.23736/S2724-606X.24.05612-4Capozzi A., Vignali M., Scambia G., Lello S. Pathophysiology and diagnostic criteria of PCOS. Minerva Obstet. Gynecol. 2025; 77(5): 361–72. https://doi.org/10.23736/S2724-606X.24.05612-4Karkera S., Agard E., Sankova L. The clinical manifestations of polycystic ovary syndrome (PCOS) and the treatment options. Eur. J. Biol. Med. Sci. Res. 2023; 11(1): 57–91. https://doi.org/10.37745/ejbmsr.2013/vol11n15791Karkera S., Agard E., Sankova L. The clinical manifestations of polycystic ovary syndrome (PCOS) and the treatment options. Eur. J. Biol. Med. Sci. Res. 2023; 11(1): 57–91. https://doi.org/10.37745/ejbmsr.2013/vol11n15791Peña A.S., Witchel S.F. Update on diagnosis of polycystic ovary syndrome during adolescence. Fertil. Steril. 2025; 124(5 Pt. 2): 956–61. https://doi.org/10.1016/j.fertnstert.2025.09.006Peña A.S., Witchel S.F. Update on diagnosis of polycystic ovary syndrome during adolescence. Fertil. Steril. 2025; 124(5 Pt. 2): 956–61. https://doi.org/10.1016/j.fertnstert.2025.09.006Concepción-Zavaleta M.J., Fuentes-Mendoza J.M., ZavaletaGutiérrez F.E., Arias-Cantor B.Y., Figueredo-Rueda M.V., Coronado-Arroyo J.C., et al. Adolescent hyperandrogenism: diagnostic challenges and therapeutic approaches. World J. Pediatr. 2025; 21(10): 973–90. https://doi.org/10.1007/s12519-025-00972-wConcepción-Zavaleta M.J., Fuentes-Mendoza J.M., ZavaletaGutiérrez F.E., Arias-Cantor B.Y., Figueredo-Rueda M.V., Coronado-Arroyo J.C., et al. Adolescent hyperandrogenism: diagnostic challenges and therapeutic approaches. World J. Pediatr. 2025; 21(10): 973–90. https://doi.org/10.1007/s12519-025-00972-wCapozzi A., Vignali M., Scambia G., Lello S. Pathophysiology and diagnostic criteria of PCOS. Minerva Obstet. Gynecol. 2025; 77(5): 361–72. https://doi.org/10.23736/S2724-606X.24.05612-4Capozzi A., Vignali M., Scambia G., Lello S. Pathophysiology and diagnostic criteria of PCOS. Minerva Obstet. Gynecol. 2025; 77(5): 361–72. https://doi.org/10.23736/S2724-606X.24.05612-4Butt M.A., Tabassum S., Hardy R.S., Kiyani M.M. Mechanistic insight into nanomedicine for polycystic ovary syndrome. Mol. Biol. Rep. 2025; 52(1): 618. https://doi.org/10.1007/s11033-025-10709-7Butt M.A., Tabassum S., Hardy R.S., Kiyani M.M. Mechanistic insight into nanomedicine for polycystic ovary syndrome. Mol. Biol. Rep. 2025; 52(1): 618. https://doi.org/10.1007/s11033-025-10709-7Chaudhary H., Patel J., Jain N.K., Panchal S., Nanavati P., Singh M., et al. Impact of CYP19A1 genetic variations on polycystic ovary syndrome: findings from a case-control study. F S Sci. 2025; 6(3): 364–73. https://doi.org/10.1016/j.xfss.2025.03.005Chaudhary H., Patel J., Jain N.K., Panchal S., Nanavati P., Singh M., et al. Impact of CYP19A1 genetic variations on polycystic ovary syndrome: findings from a case-control study. F S Sci. 2025; 6(3): 364–73. https://doi.org/10.1016/j.xfss.2025.03.005Di Michele S., Fulghesu A.M., Pittui E., Cordella M., Sicilia G., Mandurino G., et al. Ultrasound assessment in polycystic ovary syndrome diagnosis: from origins to future perspectives-a comprehensive review. Biomedicines. 2025; 13(2): 453. https://doi.org/10.3390/biomedicines13020453Di Michele S., Fulghesu A.M., Pittui E., Cordella M., Sicilia G., Mandurino G., et al. Ultrasound assessment in polycystic ovary syndrome diagnosis: from origins to future perspectives-a comprehensive review. Biomedicines. 2025; 13(2): 453. https://doi.org/10.3390/biomedicines13020453Uçar M., Ata A., Barutçuoğlu B., Ak G., Habif S., Parıldar Z., et al. Assessment of hormone measurement methods in girls with premature adrenarche, polycystic ovary syndrome, and nonclassical congenital adrenal hyperplasia. Turk. J. Pediatr. 2025; 67(5): 692–9. https://doi.org/10.24953/turkjpediatr.2025.5939Uçar M., Ata A., Barutçuoğlu B., Ak G., Habif S., Parıldar Z., et al. Assessment of hormone measurement methods in girls with premature adrenarche, polycystic ovary syndrome, and nonclassical congenital adrenal hyperplasia. Turk. J. Pediatr. 2025; 67(5): 692–9. https://doi.org/10.24953/turkjpediatr.2025.5939Zhong Y., Ding J., Xia F. DNA methylation and its impact on ovarian steroidogenesis in women with polycystic ovary syndrome: insights from human and animal models. Arch. Gynecol. Obstet. 2025; 312(2): 363–74. https://doi.org/10.1007/s00404-025-08048-wZhong Y., Ding J., Xia F. DNA methylation and its impact on ovarian steroidogenesis in women with polycystic ovary syndrome: insights from human and animal models. Arch. Gynecol. Obstet. 2025; 312(2): 363–74. https://doi.org/10.1007/s00404-025-08048-wNandi A., Singh K., Sharma K. Advancement in early diagnosis of polycystic ovary syndrome: biomarker-driven innovative diagnostic sensor. Microchimica Acta. 2025; 192(5): 1–23. https://doi.org/10.1007/s00604-025-07187-wNandi A., Singh K., Sharma K. Advancement in early diagnosis of polycystic ovary syndrome: biomarker-driven innovative diagnostic sensor. Microchimica Acta. 2025; 192(5): 1–23. https://doi.org/10.1007/s00604-025-07187-wSzkodziak P., Szkodziak F., Trzeciak K., Woźniak S., Mlynarczyk M., Paszkowski T. Insulin resistance in polycystic ovary syndrome phenotypes and the vicious cycle model in its etiology. Sci. Rep. 2025; 15(1): 42649. https://doi.org/10.1038/s41598-025-26718-2Szkodziak P., Szkodziak F., Trzeciak K., Woźniak S., Mlynarczyk M., Paszkowski T. Insulin resistance in polycystic ovary syndrome phenotypes and the vicious cycle model in its etiology. Sci. Rep. 2025; 15(1): 42649. https://doi.org/10.1038/s41598-025-26718-2Prosperi S., Chiarelli F. Insulin resistance, metabolic syndrome and polycystic ovaries: an intriguing conundrum. Front. Endocrinol. (Lausanne). 2025; 16: 1669716. https://doi.org/10.3389/fendo.2025.1669716Prosperi S., Chiarelli F. Insulin resistance, metabolic syndrome and polycystic ovaries: an intriguing conundrum. Front. Endocrinol. (Lausanne). 2025; 16: 1669716. https://doi.org/10.3389/fendo.2025.1669716Armanini D., Boscaro M., Bordin L., Sabbadin C. Controversies in the pathogenesis, diagnosis and treatment of PCOS: focus on insulin resistance, inflammation, and hyperandrogenism. Int. J. Mol. Sci. 2022; 23(8): 4110. https://doi.org/10.3390/ijms23084110Armanini D., Boscaro M., Bordin L., Sabbadin C. Controversies in the pathogenesis, diagnosis and treatment of PCOS: focus on insulin resistance, inflammation, and hyperandrogenism. Int. J. Mol. Sci. 2022; 23(8): 4110. https://doi.org/10.3390/ijms23084110Rizzi A., Polimeno T., Leo M.L., Moriconi A., Policriti M., Tartaglione L., et al. Different glucose variability in women with polycystic ovary syndrome with and without insulin resistance: a pilot study. Endocr. Pract. 2025; 31(11): 1407–13. https://doi.org/10.1016/j.eprac.2025.06.020Rizzi A., Polimeno T., Leo M.L., Moriconi A., Policriti M., Tartaglione L., et al. Different glucose variability in women with polycystic ovary syndrome with and without insulin resistance: a pilot study. Endocr. Pract. 2025; 31(11): 1407–13. https://doi.org/10.1016/j.eprac.2025.06.020Nowak-Ciołek M., Stachowiak J.J., Krok K., Sokal J., Malczyk Ż., Skrzyńska K., et al. Adolescent PCOS and longterm metabolic risk: insights from triglycerides to high-density lipoprotein cholesterol ratio and high-density lipoprotein cholesterol profiles. Front. Endocrinol. (Lausanne). 2025; 16: 1579217. https://doi.org/10.3389/fendo.2025.1579217Nowak-Ciołek M., Stachowiak J.J., Krok K., Sokal J., Malczyk Ż., Skrzyńska K., et al. Adolescent PCOS and longterm metabolic risk: insights from triglycerides to high-density lipoprotein cholesterol ratio and high-density lipoprotein cholesterol profiles. Front. Endocrinol. (Lausanne). 2025; 16: 1579217. https://doi.org/10.3389/fendo.2025.1579217Swauger S.E., Crimmins N.A. Identification and treatment of polycystic ovary syndrome in adolescents: A primer for the lipidologist. J. Clin. Lipidol. 2025; 19(4S): 37–42. https://doi.org/10.1016/j.jacl.2025.04.184Swauger S.E., Crimmins N.A. Identification and treatment of polycystic ovary syndrome in adolescents: A primer for the lipidologist. J. Clin. Lipidol. 2025; 19(4S): 37–42. https://doi.org/10.1016/j.jacl.2025.04.184Zhu R., Yu X., Li Y. Identification and validation of biomarkers associated with glycolysis in polycystic ovarian syndrome. Sci. Rep. 2025; 15(1): 27199. https://doi.org/10.1038/s41598-025-11591-wZhu R., Yu X., Li Y. Identification and validation of biomarkers associated with glycolysis in polycystic ovarian syndrome. Sci. Rep. 2025; 15(1): 27199. https://doi.org/10.1038/s41598-025-11591-wReich L.A., St Fleur R.G., Gjelsvik A., Field A.E., Ziobrowski H.N. Prospective associations of adolescent obesity phenotypes with self reported polycystic ovary syndrome diagnosis in young adulthood. Hum. Reprod. 2025; 40(3): 545–52. https://doi.org/10.1093/humrep/deae294Reich L.A., St Fleur R.G., Gjelsvik A., Field A.E., Ziobrowski H.N. Prospective associations of adolescent obesity phenotypes with self reported polycystic ovary syndrome diagnosis in young adulthood. Hum. Reprod. 2025; 40(3): 545–52. https://doi.org/10.1093/humrep/deae294Calcaterra V., Verduci E., Cena H., Magenes V.C., Todisco C.F., Tenuta E., et al. Polycystic ovary syndrome in insulin-resistant adolescents with obesity: the role of nutrition therapy and food supplements as a strategy to protect fertility. Nutrients. 2021; 13(6): 1848. https://doi.org/10.3390/nu13061848Calcaterra V., Verduci E., Cena H., Magenes V.C., Todisco C.F., Tenuta E., et al. Polycystic ovary syndrome in insulin-resistant adolescents with obesity: the role of nutrition therapy and food supplements as a strategy to protect fertility. Nutrients. 2021; 13(6): 1848. https://doi.org/10.3390/nu13061848Cehic M., Milenkovic T., Todorovic S., Mitrovic K., Zaric S.P., Cvetkovic D., et al. Beyond PCOS: an unusual presentation of type A insulin resistance syndrome. J. Pediatr. Adolesc. Gynecol. 2026; 39(1): 131–4. https://doi.org/10.1016/j.jpag.2025.09.013Cehic M., Milenkovic T., Todorovic S., Mitrovic K., Zaric S.P., Cvetkovic D., et al. Beyond PCOS: an unusual presentation of type A insulin resistance syndrome. J. Pediatr. Adolesc. Gynecol. 2026; 39(1): 131–4. https://doi.org/10.1016/j.jpag.2025.09.013Dutta S., Sengupta P., Rao S., Elgarawany G.E., Samrot A.V., Rosas I.M., et al. Targeting Polycystic Ovary Syndrome (PCOS) pathophysiology with flavonoids: from adipokine-cytokine crosstalk to insulin resistance and reproductive dysfunctions. Pharmaceuticals (Basel). 2025; 18(10): 1575. https://doi.org/10.3390/ph18101575Dutta S., Sengupta P., Rao S., Elgarawany G.E., Samrot A.V., Rosas I.M., et al. Targeting Polycystic Ovary Syndrome (PCOS) pathophysiology with flavonoids: from adipokine-cytokine crosstalk to insulin resistance and reproductive dysfunctions. Pharmaceuticals (Basel). 2025; 18(10): 1575. https://doi.org/10.3390/ph18101575Sharma U., Sahu A., Thakur N., Choudhary R.K., Shekhar H., Haque S., et al. Journey through the gut-inflammation axis in polycystic ovary syndrome: the microbiota’s role in shaping inflammatory pathways. Mol. Cell Biochem. 2025. https://doi.org/10.1007/s11010-025-05409-6Sharma U., Sahu A., Thakur N., Choudhary R.K., Shekhar H., Haque S., et al. Journey through the gut-inflammation axis in polycystic ovary syndrome: the microbiota’s role in shaping inflammatory pathways. Mol. Cell Biochem. 2025. https://doi.org/10.1007/s11010-025-05409-6Morshedzadeh N., Behrouz V., Ahmadi A.R. Cross-sectional study of the relationship between dietary inflammatory index and inflammatory hormonal and metabolic profiles in polycystic ovary syndrome. Sci. Rep. 2025; 15(1): 40211. https://doi.org/10.1038/s41598-025-24046-zMorshedzadeh N., Behrouz V., Ahmadi A.R. Cross-sectional study of the relationship between dietary inflammatory index and inflammatory hormonal and metabolic profiles in polycystic ovary syndrome. Sci. Rep. 2025; 15(1): 40211. https://doi.org/10.1038/s41598-025-24046-zKara L., Cicek D., Sarikaya E., Gok E., Berber U., Siraz U.G., et al. Adolescent PCOS and metabolic health: An analysis of fat, muscle, and hormones. Eur. J. Obstet. Gynecol. Reprod. Biol. 2025; 314: 114648. https://doi.org/10.1016/j.ejogrb.2025.114648Kara L., Cicek D., Sarikaya E., Gok E., Berber U., Siraz U.G., et al. Adolescent PCOS and metabolic health: An analysis of fat, muscle, and hormones. Eur. J. Obstet. Gynecol. Reprod. Biol. 2025; 314: 114648. https://doi.org/10.1016/j.ejogrb.2025.114648Javed M., Suramya., Ahmad S., Raisuddin S. Chemicallyinduced histopathological progression in the polycystic ovary syndrome (PCOS) – a review. Toxicol. Res. 2025; 41(5): 437–53. https://doi.org/10.1007/s43188-025-00296-xJaved M., Suramya., Ahmad S., Raisuddin S. Chemicallyinduced histopathological progression in the polycystic ovary syndrome (PCOS) – a review. Toxicol. Res. 2025; 41(5): 437–53. https://doi.org/10.1007/s43188-025-00296-xQi J., Zhu Z., Cao Y., Li B., Li J., Hu S., et al. Deficiency of LPCAT3 compromises endometrial stromal cell decidualization in polycystic ovary syndrome. FASEB J. 2025; 39(12): e70687. https://doi.org/10.1096/fj.202402967RQi J., Zhu Z., Cao Y., Li B., Li J., Hu S., et al. Deficiency of LPCAT3 compromises endometrial stromal cell decidualization in polycystic ovary syndrome. FASEB J. 2025; 39(12): e70687. https://doi.org/10.1096/fj.202402967RLouwers Y.V., Visser J.A., Dunaif A., Laven J.S.E. Polycystic ovary syndrome: origins and implications: Genetics of polycystic ovary syndrome (PCOS). Reproduction. 2025; 170(5): e250126. https://doi.org/10.1530/REP-25-0126Louwers Y.V., Visser J.A., Dunaif A., Laven J.S.E. Polycystic ovary syndrome: origins and implications: Genetics of polycystic ovary syndrome (PCOS). Reproduction. 2025; 170(5): e250126. https://doi.org/10.1530/REP-25-0126Zhang C., Li Y., Wang Y., Hu S., Liu Y., Liang X., et al. Genetic associations of metabolic factors and therapeutic drug targets with polycystic ovary syndrome. J. Adv. Res. 2025; 75: 581–90. https://doi.org/10.1016/j.jare.2024.10.038Zhang C., Li Y., Wang Y., Hu S., Liu Y., Liang X., et al. Genetic associations of metabolic factors and therapeutic drug targets with polycystic ovary syndrome. J. Adv. Res. 2025; 75: 581–90. https://doi.org/10.1016/j.jare.2024.10.038Sankaranarayanan L., Brewer K.J., Morrow S., Johnson G.D., Barrera A., Venukuttan R., et al. Gene regulatory activity associated with polycystic ovary syndrome revealed DENND1Adependent testosterone production. Nat. Commun. 2025; 16(1): 7697. https://doi.org/10.1038/s41467-025-62884-7Sankaranarayanan L., Brewer K.J., Morrow S., Johnson G.D., Barrera A., Venukuttan R., et al. Gene regulatory activity associated with polycystic ovary syndrome revealed DENND1Adependent testosterone production. Nat. Commun. 2025; 16(1): 7697. https://doi.org/10.1038/s41467-025-62884-7Brookhart C.D., Naroji S. Abnormal uterine bleeding, polycystic ovary syndrome, and heavy menstrual bleeding in adolescents. Pediatr. Ann. 2025; 54(9): e302–7. https://doi.org/10.3928/19382359-20250707-02Brookhart C.D., Naroji S. Abnormal uterine bleeding, polycystic ovary syndrome, and heavy menstrual bleeding in adolescents. Pediatr. Ann. 2025; 54(9): e302–7. https://doi.org/10.3928/19382359-20250707-02Zheng Z., Ma Y., Shi Y., Xu Y. Associations between kisspeptin hormone level and its genetic polymorphisms with polycystic ovary syndrome. Int. J. Gynaecol. Obstet. 2026; 172(1): 383–95. https://doi.org/10.1002/ijgo.70411Zheng Z., Ma Y., Shi Y., Xu Y. Associations between kisspeptin hormone level and its genetic polymorphisms with polycystic ovary syndrome. Int. J. Gynaecol. Obstet. 2026; 172(1): 383–95. https://doi.org/10.1002/ijgo.70411Kaur M., Singh S., Beri A., Kaur A. Exploring genotypephenotype correlation of FSHR polymorphisms in polycystic ovary syndrome. BMC Endocr. Disord. 2025; 25(1): 239. https://doi.org/10.1186/s12902-025-01979-0Kaur M., Singh S., Beri A., Kaur A. Exploring genotypephenotype correlation of FSHR polymorphisms in polycystic ovary syndrome. BMC Endocr. Disord. 2025; 25(1): 239. https://doi.org/10.1186/s12902-025-01979-0Mohammed S., Sundaram V., Cockburn B.N., Motilal S., Ottey S., Azziz R. The association of polycystic ovary syndromelike clinical features and socioeconomic status on health-related quality of life. Womens Health Rep. (New Rochelle). 2025; 6(1): 493–503. https://doi.org/10.1089/whr.2025.0008Mohammed S., Sundaram V., Cockburn B.N., Motilal S., Ottey S., Azziz R. The association of polycystic ovary syndromelike clinical features and socioeconomic status on health-related quality of life. Womens Health Rep. (New Rochelle). 2025; 6(1): 493–503. https://doi.org/10.1089/whr.2025.0008Ozga M., Jurewicz J. Environmental exposure to selected nonpersistent endocrine disrupting chemicals and polycystic ovary syndrome: a systematic review. Int. J. Occup. Med. Environ. Health. 2025; 38(2): 98–121. https://doi.org/10.13075/ijomeh.1896.02551Ozga M., Jurewicz J. Environmental exposure to selected nonpersistent endocrine disrupting chemicals and polycystic ovary syndrome: a systematic review. Int. J. Occup. Med. Environ. Health. 2025; 38(2): 98–121. https://doi.org/10.13075/ijomeh.1896.02551Saltanat S., Ahmad N., Sayyed S., Ahmad W., Sayyed Z.R., Shahabuddin F. Analysis of hirsutism as a symptom of Ihtibās al-Tamth (Amenorrhea) and its relation to polycystic ovary syndrome. Altern. Ther. Health Med. 2025; 31(5): 78–89.Saltanat S., Ahmad N., Sayyed S., Ahmad W., Sayyed Z.R., Shahabuddin F. Analysis of hirsutism as a symptom of Ihtibās al-Tamth (Amenorrhea) and its relation to polycystic ovary syndrome. Altern. Ther. Health Med. 2025; 31(5): 78–89.Wang M., Zhang S., He J., Zhang T., Zhu H., Sun R., et al. Biochemical classification diagnosis of polycystic ovary syndrome based on serum steroid hormones. J. Steroid Biochem. Mol. Biol. 2025; 245: 106626. https://doi.org/10.1016/j.jsbmb.2024.106626Wang M., Zhang S., He J., Zhang T., Zhu H., Sun R., et al. Biochemical classification diagnosis of polycystic ovary syndrome based on serum steroid hormones. J. Steroid Biochem. Mol. Biol. 2025; 245: 106626. https://doi.org/10.1016/j.jsbmb.2024.106626Vuong L.N., Ho V.N.A., Le A.H., Nguyen N.T., Pham T.D., Nguyen M.H.N., et al. Hormone-free vs. follicle-stimulating hormone-primed infertility treatment of women with polycystic ovary syndrome using biphasic in vitro maturation: a randomized controlled trial. Fertil. Steril. 2025; 123(2): 253–61. https://doi.org/10.1016/j.fertnstert.2024.09.010Vuong L.N., Ho V.N.A., Le A.H., Nguyen N.T., Pham T.D., Nguyen M.H.N., et al. Hormone-free vs. follicle-stimulating hormone-primed infertility treatment of women with polycystic ovary syndrome using biphasic in vitro maturation: a randomized controlled trial. Fertil. Steril. 2025; 123(2): 253–61. https://doi.org/10.1016/j.fertnstert.2024.09.010Reka S., Praba T.S., Prasanna M., Reddy V.N.N., Amirtharajan R. Automated high precision PCOS detection through a segment anything model on super resolution ultrasound ovary images. Sci. Rep. 2025; 15(1): 16832. https://doi.org/10.1038/s41598-025-01744-2Reka S., Praba T.S., Prasanna M., Reddy V.N.N., Amirtharajan R. Automated high precision PCOS detection through a segment anything model on super resolution ultrasound ovary images. Sci. Rep. 2025; 15(1): 16832. https://doi.org/10.1038/s41598-025-01744-2Moro F., Giudice M.T., Ciancia M., Zace D., Baldassari G., Vagni M., et al. Application of artificial intelligence to ultrasound imaging for benign gynecological disorders: systematic review. Ultrasound Obstet. Gynecol. 2025; 65(3): 295–302. https://doi.org/10.1002/uog.29171Moro F., Giudice M.T., Ciancia M., Zace D., Baldassari G., Vagni M., et al. Application of artificial intelligence to ultrasound imaging for benign gynecological disorders: systematic review. Ultrasound Obstet. Gynecol. 2025; 65(3): 295–302. https://doi.org/10.1002/uog.29171Chen J.Y., Chen W.J., Zhu Z.Y., Xu S., Huang L.L., Tan W.Q., et al. Screening of serum biomarkers in patients with PCOS through lipid omics and ensemble machine learning. PLoS One. 2025; 20(1): e0313494. https://doi.org/10.1371/journal.pone.0313494Chen J.Y., Chen W.J., Zhu Z.Y., Xu S., Huang L.L., Tan W.Q., et al. Screening of serum biomarkers in patients with PCOS through lipid omics and ensemble machine learning. PLoS One. 2025; 20(1): e0313494. https://doi.org/10.1371/journal.pone.0313494Bilici M.E., Şıklar Z., Çetinkaya S., Özsu E., Aycan Z., Berberoğlu M. Adrenal hypoandrogenism in adolescents with premature ovarian insufficiency. J. Pediatr. Endocrinol. Metab. 2025; 38(3): 262–70. https://doi.org/10.1515/jpem-2024-0415Bilici M.E., Şıklar Z., Çetinkaya S., Özsu E., Aycan Z., Berberoğlu M. Adrenal hypoandrogenism in adolescents with premature ovarian insufficiency. J. Pediatr. Endocrinol. Metab. 2025; 38(3): 262–70. https://doi.org/10.1515/jpem-2024-0415Damoulaki E., Sioutis D., Sarli V., Trakakis E., Mastorakos G., Katoulis A., et al. Polycystic ovary syndrome-associated acne: the interplay of hyperandrogenism, insulin resistance, and therapeutic strategies. Cureus. 2025; 17(11): e98103. https://doi.org/10.7759/cureus.98103Damoulaki E., Sioutis D., Sarli V., Trakakis E., Mastorakos G., Katoulis A., et al. Polycystic ovary syndrome-associated acne: the interplay of hyperandrogenism, insulin resistance, and therapeutic strategies. Cureus. 2025; 17(11): e98103. https://doi.org/10.7759/cureus.98103Agirsoy M., Oehlschlaeger M.A. A machine learning approach for non-invasive PCOS diagnosis from ultrasound and clinical features. Sci. Rep. 2025; 15(1): 33638. https://doi.org/10.1038/s41598-025-10453-9Agirsoy M., Oehlschlaeger M.A. A machine learning approach for non-invasive PCOS diagnosis from ultrasound and clinical features. Sci. Rep. 2025; 15(1): 33638. https://doi.org/10.1038/s41598-025-10453-9Tong C., Wu Y., Zhuang Z., Yu Y. A diagnostic model for polycystic ovary syndrome based on machine learning. Sci. Rep. 2025; 15(1): 9821. https://doi.org/10.1038/s41598-025-92630-4Tong C., Wu Y., Zhuang Z., Yu Y. A diagnostic model for polycystic ovary syndrome based on machine learning. Sci. Rep. 2025; 15(1): 9821. https://doi.org/10.1038/s41598-025-92630-4Wang J., Chen R., Long H., He J., Tang M., Su M., et al. Artificial intelligence in polycystic ovarian syndrome management: past, present, and future. Radiol. Med. 2025; 130(9): 1409–41. https://doi.org/10.1007/s11547-025-02032-9Wang J., Chen R., Long H., He J., Tang M., Su M., et al. Artificial intelligence in polycystic ovarian syndrome management: past, present, and future. Radiol. Med. 2025; 130(9): 1409–41. https://doi.org/10.1007/s11547-025-02032-9Panjwani B., Yadav J., Mohan V., Agarwal N., Agarwal S. Optimized machine learning for the early detection of polycystic ovary syndrome in women. Sensors (Basel). 2025; 25(4): 1166. https://doi.org/10.3390/s25041166Panjwani B., Yadav J., Mohan V., Agarwal N., Agarwal S. Optimized machine learning for the early detection of polycystic ovary syndrome in women. Sensors (Basel). 2025; 25(4): 1166. https://doi.org/10.3390/s25041166Chen W., Miao J., Chen J., Chen J. Development of machine learning models for diagnostic biomarker identification and immune cell infiltration analysis in PCOS. J. Ovarian Res. 2025; 18(1): 1. https://doi.org/10.1186/s13048-024-01583-1Chen W., Miao J., Chen J., Chen J. Development of machine learning models for diagnostic biomarker identification and immune cell infiltration analysis in PCOS. J. Ovarian Res. 2025; 18(1): 1. https://doi.org/10.1186/s13048-024-01583-1Wu T., Liu Y., Kong F., Hu J., Liu Y., Yang J., et al. Improvement of endocrine and metabolic conditions in patients with polycystic ovary syndrome through acupuncture and its combined therapies: a systematic review and meta-analysis. Ann. Med. 2025; 57(1): 2477295. https://doi.org/10.1080/07853890.2025.2477295Wu T., Liu Y., Kong F., Hu J., Liu Y., Yang J., et al. Improvement of endocrine and metabolic conditions in patients with polycystic ovary syndrome through acupuncture and its combined therapies: a systematic review and meta-analysis. Ann. Med. 2025; 57(1): 2477295. https://doi.org/10.1080/07853890.2025.2477295Xu H., Mao L., Huang W., Huang Q., Li L., Liu Y. Gene association study between polycystic ovary syndrome and metabolic syndrome: a transcriptomic analysis and machine learning approach. J. Ovarian Res. 2025; 18(1): 220. https://doi.org/10.1186/s13048-025-01787-zXu H., Mao L., Huang W., Huang Q., Li L., Liu Y. Gene association study between polycystic ovary syndrome and metabolic syndrome: a transcriptomic analysis and machine learning approach. J. Ovarian Res. 2025; 18(1): 220. https://doi.org/10.1186/s13048-025-01787-zMoore A.M. Neuroendocrine mechanisms responsible for elevated gonadotrophin-releasing hormone and luteinising hormone pulses in polycystic ovary syndrome. J. Neuroendocrinol. 2025; 37(8): e70028. https://doi.org/10.1111/jne.70028Moore A.M. Neuroendocrine mechanisms responsible for elevated gonadotrophin-releasing hormone and luteinising hormone pulses in polycystic ovary syndrome. J. Neuroendocrinol. 2025; 37(8): e70028. https://doi.org/10.1111/jne.70028Zhang Y., Chen Z.J., Zhao H. Polycystic ovary syndrome: A metabolic disorder with therapeutic opportunities. Cell Metab. 2025; 37(10): 1932–49. https://doi.org/10.1016/j.cmet.2025.08.002Zhang Y., Chen Z.J., Zhao H. Polycystic ovary syndrome: A metabolic disorder with therapeutic opportunities. Cell Metab. 2025; 37(10): 1932–49. https://doi.org/10.1016/j.cmet.2025.08.002Saadati S., Mason T., Godini R., Vanky E., Teede H., Mousa A. Metformin use in women with polycystic ovary syndrome (PCOS): Opportunities, benefits, and clinical challenges. Diabetes Obes. Metab. 2025; 3(Suppl. 3): 31–47. https://doi.org/10.1111/dom.16422Saadati S., Mason T., Godini R., Vanky E., Teede H., Mousa A. Metformin use in women with polycystic ovary syndrome (PCOS): Opportunities, benefits, and clinical challenges. Diabetes Obes. Metab. 2025; 3(Suppl. 3): 31–47. https://doi.org/10.1111/dom.16422Arshad A., Armeni E., Broughton S., Ali A., Blendis E., Gleeson H., et al. Polycystic ovary syndrome: pragmatic management across levels of care. Gynecol. Endocrinol. 2025; 41(1): 2574874. https://doi.org/10.1080/09513590.2025.2574874Arshad A., Armeni E., Broughton S., Ali A., Blendis E., Gleeson H., et al. Polycystic ovary syndrome: pragmatic management across levels of care. Gynecol. Endocrinol. 2025; 41(1): 2574874. https://doi.org/10.1080/09513590.2025.2574874Gautam R., Maan P., Jyoti A., Kumar A., Malhotra N., Arora T. The role of lifestyle interventions in PCOS management: a systematic review. Nutrients. 2025; 17(2): 310. https://doi.org/10.3390/nu17020310Gautam R., Maan P., Jyoti A., Kumar A., Malhotra N., Arora T. The role of lifestyle interventions in PCOS management: a systematic review. Nutrients. 2025; 17(2): 310. https://doi.org/10.3390/nu17020310Lakshmi Narayanan P., Sugumar S., Rushendran R., Vellapandian C. Next-generation approaches in targeting polycystic ovarian syndrome: innovative strategies. Curr. Med. Chem. 2025; 33(1): 57–75. https://doi.org/10.2174/0109298673368951250404170052Lakshmi Narayanan P., Sugumar S., Rushendran R., Vellapandian C. Next-generation approaches in targeting polycystic ovarian syndrome: innovative strategies. Curr. Med. Chem. 2025; 33(1): 57–75. https://doi.org/10.2174/0109298673368951250404170052Pulluparambil S.J., Subrahmanya Bhat. Exploring the feature prioritization and data sampling of PCOS diagnosis via densely connected attention based squeeze deep learning detection model. J. Steroid Biochem. Mol. Biol. 2025; 258: 106933. https://doi.org/10.1016/j.jsbmb.2025.106933Pulluparambil S.J., Subrahmanya Bhat. Exploring the feature prioritization and data sampling of PCOS diagnosis via densely connected attention based squeeze deep learning detection model. J. Steroid Biochem. Mol. Biol. 2025; 258: 106933. https://doi.org/10.1016/j.jsbmb.2025.106933

The authors declare that there are no conflicts of interest present.