rospedРоссийский педиатрический журнал имени М.Я. СтуденикинаM.Ya. Studenikin Russian Pediatric JournalФГАУ «НМИЦ здоровья детей» Минздрава России10.46563/1560-9561-2022-25-5-350-356eybiharosped-209Research ArticleОБЗОРЫREVIEWSОсобенности определения диффузионной способности лёгких по монооксиду углерода при муковисцидозе у детейFeatures of determining the diffusion capacity of the lungs by carbon monoxide in cystic fibrosis childrenhttps://orcid.org/0000-0003-3037-9384БыстроваСерафима ГригорьевнаBystrovaSerafima G.

Аспирант каф. педиатрии и детской ревматологии КИДЗ им. Н.Ф. Филатова ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» (Сеченовский университет); лаборант лаб. редких наследственных болезней у детей ФГАУ «НМИЦ здоровья детей» Минздрава России.

e-mail: cerafima.bystrova@yandex.ru

MD, PhD student in the Department of Pediatrics and Pediatric Rheumatology, N.F. Filatov Clinical Institute of Children’s Health, I.M. Sechenov First Moscow State Medical University (Sechenov University), assistant in the Laboratory of childhood rare genetic diseases, National Medical Research Center for Children’s Health, Ministry of Health of the Russian Federation.

e-mail: cerafima.bystrova@yandex.ru

cerafima.bystrova@yandex.ruФГАОУ ВО «Первый медицинский государственный медицинский университет им. И.М. Сеченова» (Сеченовский университет); ФГАУ «Национальный медицинский исследовательский центр здоровья детей» Минздрава РоссииI.M. Sechenov First Moscow State Medical University (Sechenov University); National Medical Research Center for Children’s Health, Ministry of Health of the Russian Federation202214092023255350356Copyright © Быстрова С.Г., 20232023Быстрова С.Г.Bystrova S.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rosped.ru/jour/article/view/209

В обзоре представлены современные данные о применении анализа диффузионной способности лёгких по монооксиду углерода у детей с муковисцидозом (МВ). Представлены характеристики теста диффузионной способности лёгких у детей и взрослых с различными формами патологии, а также описаны противоречивые данные использования этого теста у больных МВ разного возраста. Обсуждается целесообразность применения анализа диффузионной способности лёгких по монооксиду углерода у больных МВ, его информативность, трудности проведения теста у детей и сложности оценки данных в зависимости от течения заболевания. Автор рекомендует шире использовать в клинической диагностике МВ такие показатели, как трансфер-фактор, альвеолярный объём и их соотношение, определяемые при тесте диффузионной способности лёгких по монооксиду углерода, у больных МВ.

Финансирование

Финансирование. Исследование не имело финансовой поддержки.

Конфликт интересов

Конфликт интересов. Автор заявляет об отсутствии конфликта интересов.

Поступила 24

Поступила 24.08.2022Принята к печати 20.09.2022Опубликована 31.10.2022

The article presents current literature data from English-language (search made in PubMed) and Russian-language (search made in eLibrary) sources about the method for measurement of the lung diffusing capacity for carbon monoxide in children with cystic fibrosis (CF). This review presents the general characteristics of this test in children and adults with various diseases, and also describes the conflicting results of studies using this method in CF patients of various ages and disease severity. The expediency, the informativeness, and difficulties of evaluation and interpretation of the test’s results, depending on the age and course of the disease of patients, are discussed. The author concludes that further research of interpretation of indicators determined during the test of the lung diffusing capacity for carbon monoxide, such as the transfer factor, alveolar volume, and their ratio in CF children is necessary.

Acknowledgment

Acknowledgment. The study had no sponsorship.

Conflict of interest

Conflict of interest. The author declares no conflict of interest.

Received

Received: August 24, 2022Accepted: September 20, 2022Published: October 31, 2022

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The authors declare that there are no conflicts of interest present.