<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rosped</journal-id><journal-title-group><journal-title xml:lang="ru">Российский педиатрический журнал имени М.Я. Студеникина</journal-title><trans-title-group xml:lang="en"><trans-title>M.Ya. Studenikin Russian Pediatric Journal</trans-title></trans-title-group></journal-title-group><publisher><publisher-name>ФГАУ «НМИЦ здоровья детей» Минздрава России</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.46563/1560-9561-2023-26-2-125-129</article-id><article-id custom-type="edn" pub-id-type="custom">vnwuep</article-id><article-id custom-type="elpub" pub-id-type="custom">rosped-22</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СОЦИАЛЬНАЯ ПЕДИАТРИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>SOCIAL PEDIATRICS</subject></subj-group></article-categories><title-group><article-title>Анализ осведомлённости родителей о хронической болезни почек у детей</article-title><trans-title-group xml:lang="en"><trans-title>Analysis of parents’ awareness on the chronic kidney disease in children</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3219-5466</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трофимова</surname><given-names>Арина Геннадьевна</given-names></name><name name-style="western" xml:lang="en"><surname>Trofimova</surname><given-names>Arina G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Зав. отд-нием заместительной почечной терапии с группой трансплантации ФГАУ «НМИЦ здоровья детей» Минздрава России</p><p>e-mail: trofimova.ag@nczd.ru</p></bio><bio xml:lang="en"><p>Head of the Department of dialysis and transplantation, National Medical Research Center for Children’s Health, Moscow, 119991, Russian Federation</p><p>e-mail: trofimova.ag@nczd.ru</p></bio><email xlink:type="simple">trofimova.ag@nczd.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8586-7946</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фисенко</surname><given-names>Андрей Петрович</given-names></name><name name-style="western" xml:lang="en"><surname>Fisenko</surname><given-names>Andrey P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Заслуженный врач Российской Федерации, доктор мед. наук, проф., директор ФГАУ «НМИЦ здоровья детей» Минздрава России</p></bio><email xlink:type="simple">director@nczd.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7358-3364</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Арзуманов</surname><given-names>Сергей Викторович</given-names></name><name name-style="western" xml:lang="en"><surname>Arzumanov</surname><given-names>Sergey V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор мед. наук, рук. группы трансплантации и заместительной почечной терапии «НИИ урологии и интервенционной радиологии им. Н.А. Лопаткина» Минздрава России, врач-трансплантолог отделения заместительной почечной терапии с группой трансплантации ФГАУ «НМИЦ здоровья детей» Минздрава России</p><p>e-mail: kidneytranspl@gmail.com</p></bio><email xlink:type="simple">kidneytranspl@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАУ «Национальный медицинский исследовательский центр здоровья детей» Минздрава России</institution></aff><aff xml:lang="en"><institution>National Medical Research Center for Children’s Health</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>09</day><month>08</month><year>2023</year></pub-date><volume>23</volume><issue>2</issue><fpage>125</fpage><lpage>129</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Трофимова А.Г., Фисенко А.П., Арзуманов С.В., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Трофимова А.Г., Фисенко А.П., Арзуманов С.В.</copyright-holder><copyright-holder xml:lang="en">Trofimova A.G., Fisenko A.P., Arzumanov S.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rosped.ru/jour/article/view/22">https://www.rosped.ru/jour/article/view/22</self-uri><abstract><p>Информирование родителей о хронической болезни почек (ХБП) является важной предпосылкой для профилактики её осложнений и сохранения здоровья детей.</p><sec><title>Цель работы</title><p>Цель работы: определить уровень информированности родителей о ХБП у детей.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. По специально разработанной форме проведено анонимное анкетирование 112 родителей детей с ХБП, проходивших лечение в отделении, осуществлена статистическая обработка полученных результатов.</p></sec><sec><title>Результаты</title><p>Результаты. У 91,6% детей диагноз ХБП был установлен на стадии С3–С5 в стационаре. Во всех случаях данный диагноз являлся «случайной находкой». При этом у 75,9% респондентов был выявлен дефицит сведений о ХБП и её лечении, а уровень информированности напрямую связан со стадией ХБП. В связи с недостаточной осведомлённостью родители признались, что не соблюдали сроки посещения ребёнком нефролога (22,9%), не выполняли рекомендации по ограничению в диете белка (19,3%), калия (36,2%) и объёма жидкости (61,5%). Одновременно причиной прогрессирования ХБП у ребёнка родители считают отсутствие диспансерного наблюдения (43,7%), позднюю диагностику (33,7%), неправильное (13,3%) и позднее начало лечения (9,6%).</p></sec><sec><title>Заключение</title><p>Заключение. Доказана низкая информированность родителей о ХБП у детей, что способствует её поздней диагностике и обусловливает низкую приверженность лечению. Необходимо совершенствование методов и форм информирования населения, включая расширение потенциала амбулаторного звена (профилактические осмотры, санитарно-просветительная работа в нефрологических школах).</p></sec><sec><title>Участие авторов</title><p>Участие авторов:Фисенко А.П., Трофимова А.Г. — концепция и дизайн исследования;Трофимова А.Г., Арзуманов С.В. — сбор и обработка материала;Трофимова А.Г. — статистическая обработка материала и написание текста;Фисенко А.П., Арзуманов С.В. — редактирование.Все соавторы — утверждение окончательного варианта статьи, ответственность за целостность всех частей статьи.</p></sec><sec><title>Финансирование</title><p>Финансирование. Исследование не имело финансовой поддержки.</p></sec><sec><title>Конфликт интересов</title><p>Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов. </p></sec><sec><title>Поступила 27</title><p>Поступила 27.02.2023Принята к печати 21.03.2023Опубликована 28.04.2023</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Informing the population about chronic kidney disease is an important factor for preventing or combating the disease, and maintaining the health of the younger generation.</p></sec><sec><title>Objective</title><p>Objective: to study the level of awareness of parents about chronic kidney disease. </p></sec><sec><title>Methods</title><p>Methods. In a specially designed form, an anonymous survey of 112 parents of children treated at the department regarding chronic kidney disease was conducted. Statistical processing of the obtained results was carried out.</p></sec><sec><title>Results</title><p>Results. In most children (91.6%), the diagnosis of chronic kidney disease was established at the stage C3–C5 in the hospital. Moreover, in 100% of cases, this diagnosis was a “random finding”; 75.9% of respondents showed lack of information about the disease and its treatment, and the level of awareness is directly related to the stage of the disease. Moreover, as a result of insufficient information, the parents admitted to fail to comply with the terms of visiting the child, a nephrologist (22.9%), the recommendations to limit the diet of protein (19.3%) and potassium (36.2%), fluid volume (61.5%). At the same time, the parents believed the cause of the progression of chronic kidney disease in the child to be the lack of follow-up (43.7%), late diagnosis (33.7%), improper treatment (13.3%), and the late beginning of the treatment (9.6%). </p></sec><sec><title>Conclusion</title><p>Conclusion. The work proved a low degree of awareness about chronic kidney disease, which contributes to the late diagnosis of the disease and low adherence to treatment. This problem requires improving methods and forms of informing the population, including expanding the capacity of outpatient care (preventive examinations, health education in nephrology schools).</p></sec><sec><title>Contribution</title><p>Contribution:Fisenko A.P., Trofimova A.G. — research concept and design of the study;Trofimova A.G., Arzuma­nov S.V. — collection and processing of material;Trofimova A.G. — statistical processing and text writing;Fisenko A.P., Arzumanov S.V. — editing.All co-authors — approval of the final version of the article, responsibility for the integrity of all parts of the article.</p></sec><sec><title>Acknowledgment</title><p>Acknowledgment. The study had no sponsorship.</p></sec><sec><title>Conflict of interest</title><p>Conflict of interest. The authors declare no conflict of interest.</p></sec><sec><title>Received</title><p>Received: February 27, 2023Accepted: March 21, 2023Published: April 28, 2023</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>информированность</kwd><kwd>хроническая болезнь почек</kwd><kwd>дети</kwd><kwd>родители</kwd></kwd-group><kwd-group xml:lang="en"><kwd>awareness</kwd><kwd>chronic kidney disease</kwd><kwd>children</kwd><kwd>parents</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Panzarino V., Lesser J., Cassani F.A. Pediatric chronic kidney disease. Adv. Pediatr. 2022; 69(1): 123–32. https://doi.org/10.1016/j.yapd.2022.03.008</mixed-citation><mixed-citation xml:lang="en">Panzarino V., Lesser J., Cassani F.A. Pediatric chronic kidney disease. Adv. Pediatr. 2022; 69(1): 123–32. https://doi.org/10.1016/j.yapd.2022.03.008</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Даминова М.А. Хроническая болезнь почек у детей: этиология, классификация и факторы прогрессирования. Вестник современной клинической медицины. 2016; 9(2): 36–41. https://doi.org/10.20969/VSKM.2016.9(2).36-41 https://elibrary.ru/vrarat</mixed-citation><mixed-citation xml:lang="en">Daminova M.A. Chronic kidney disease in children: etiology, classification and factors progression. Vestnik sovremennoy klinicheskoy meditsiny. 2016; 9(2): 36–41. https://doi.org/10.20969/VSKM.2016.9(2).36-41 https://www.elibrary.ru/vrarat (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Dart A. Sociodemographic determinants of chronic kidney disease in Indigenous children. Pediatr. Nephrol. 2022; 37(3): 547–53. https://doi.org/10.1007/s00467-021-05110-y</mixed-citation><mixed-citation xml:lang="en">Dart A. Sociodemographic determinants of chronic kidney disease in Indigenous children. Pediatr. Nephrol. 2022; 37(3): 547–53. https://doi.org/10.1007/s00467-021-05110-y</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Khalid R., Van Zwieten A., Kim S., Didsbury M., Francis A., Mctaggart S., et al. Association between socioeconomic status and academic performance in children and adolescents with chronic kidney disease. Pediatr. Nephrol. 2022; 37(12): 3195–204. https://doi.org/10.1007/s00467-022-05515-3</mixed-citation><mixed-citation xml:lang="en">Khalid R., Van Zwieten A., Kim S., Didsbury M., Francis A., Mctaggart S., et al. Association between socioeconomic status and academic performance in children and adolescents with chronic kidney disease. Pediatr. Nephrol. 2022; 37(12): 3195–204. https://doi.org/10.1007/s00467-022-05515-3</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Harada R., Hamasaki Y., Okuda Y., Hamada R., Ishikura K. Epidemiology of pediatric chronic kidney disease/kidney failure: learning from registries and cohort studies. Pediatr. Nephrol. 2022; 37(6): 1215–29. https://doi.org/10.1007/s00467-021-05145-1</mixed-citation><mixed-citation xml:lang="en">Harada R., Hamasaki Y., Okuda Y., Hamada R., Ishikura K. Epidemiology of pediatric chronic kidney disease/kidney failure: learning from registries and cohort studies. Pediatr. Nephrol. 2022; 37(6): 1215–29. https://doi.org/10.1007/s00467-021-05145-1</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Смирнов А.В., Шилов Е.М., Добронравов В.А., Каюков И.Г., Бобкова И.Н., Швецов М.Ю. и др. Национальные рекомендации. Хроническая болезнь почек: основные принципы скрининга, диагностики, профилактики и подходы к лечению. СПб.: Левша; 2012.</mixed-citation><mixed-citation xml:lang="en">Smirnov A.V., Shilov E.M., Dobronravov V.A., Kayukov I.G., Bobkova I.N., Shvetsov M.Yu., et al. National Recommendations. Chronic Kidney Disease: Basic Principles of Screening, Diagnosis, Prevention and Approaches to Treatment [Natsional’nye rekomendatsii. Khronicheskaya bolezn’ pochek: osnovnye printsipy skrininga, diagnostiki, profilaktiki i podkhody k lecheniyu]. St. Petersburg: Levsha; 2012. (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">KDIGO Conference Participants. Genetics in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int. 2022; 101(6): 1126–41. https://doi.org/10.1016/j.kint.2022.03.019</mixed-citation><mixed-citation xml:lang="en">KDIGO Conference Participants. Genetics in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int. 2022; 101(6): 1126–41. https://doi.org/10.1016/j.kint.2022.03.019</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Pierce C.B., Muñoz A., Ng D.K., Warady B.A., Furth S.L., Schwartz G.J. Age- and sex-dependent clinical equations to estimate glomerular filtration rates in children and young adults with chronic kidney disease. Kidney Int. 2021; 99(4): 948–56. https://doi.org/10.1016/j.kint.2020.10.047</mixed-citation><mixed-citation xml:lang="en">Pierce C.B., Muñoz A., Ng D.K., Warady B.A., Furth S.L., Schwartz G.J. Age- and sex-dependent clinical equations to estimate glomerular filtration rates in children and young adults with chronic kidney disease. Kidney Int. 2021; 99(4): 948–56. https://doi.org/10.1016/j.kint.2020.10.047</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Вялкова А.А., Зорин И.В., Гордиенко Л.М. Вопросы диагностики хронической болезни почек у детей. Практическая медицина. 2013; (6): 72–7. https://elibrary.ru/rorolb</mixed-citation><mixed-citation xml:lang="en">Vyalkova A.A., Zorin I.V., Gordienko L.M. Problems of diagnosis of chronic kidney disease in children. Prakticheskaya meditsina. 2013; (6): 72–7. https://elibrary.ru/rorolb (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Knoers N., Antignac C., Bergmann C., Dahan K., Giglio S., Heidet L., et al. Genetic testing in the diagnosis of chronic kidney disease: recommendations for clinical practice. Nephrol. Dial. Transplant. 2022; 37(2): 239–54. https://doi.org/10.1093/ndt/gfab218</mixed-citation><mixed-citation xml:lang="en">Knoers N., Antignac C., Bergmann C., Dahan K., Giglio S., Heidet L., et al. Genetic testing in the diagnosis of chronic kidney disease: recommendations for clinical practice. Nephrol. Dial. Transplant. 2022; 37(2): 239–54. https://doi.org/10.1093/ndt/gfab218</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Соколова В.В. Некоторые результаты изучения мнения родителей о качестве стационарной помощи детям. Врач-аспирант. 2017; 81(2.2): 286–94. https://elibrary.ru/yjkklf</mixed-citation><mixed-citation xml:lang="en">Sokolova V.V. Some results of studying the opinion of parents about the quality of inpatient care for children. Vrach-aspirant. 2017; 81(2.2): 286–94. https://elibrary.ru/yjkklf (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Benoit S.W., Ciccia E.A., Devarajan P. Cystatin C as a biomarker of chronic kidney disease: latest developments. Expert. Rev. Mol. Diagn. 2020; 20(10): 1019–26. https://doi.org/10.1080/14737159.2020.1768849</mixed-citation><mixed-citation xml:lang="en">Benoit S.W., Ciccia E.A., Devarajan P. Cystatin C as a biomarker of chronic kidney disease: latest developments. Expert. Rev. Mol. Diagn. 2020; 20(10): 1019–26. https://doi.org/10.1080/14737159.2020.1768849</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">García-Bello J.A., Gómez-Díaz R.A., Contreras-Rodríguez A., Sánchez-Barbosa L., Mondragón-González R., Gallardo-Montoya J.M., et al. Endothelial dysfunction in children with chronic kidney disease. Nefrologia (Engl. Ed). 2021; 41(4): 436–45. https://doi.org/10.1016/j.nefroe.2020.10.002</mixed-citation><mixed-citation xml:lang="en">García-Bello J.A., Gómez-Díaz R.A., Contreras-Rodríguez A., Sánchez-Barbosa L., Mondragón-González R., Gallardo-Montoya J.M., et al. Endothelial dysfunction in children with chronic kidney disease. Nefrologia (Engl. Ed). 2021; 41(4): 436–45. https://doi.org/10.1016/j.nefroe.2020.10.002</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Трофимова А.Г. Оценка информированности родителей детей с хронической болезнью почек о заболевании. Медицина: теория и практика. 2019; (4): 549. https://elibrary.ru/tnnstc</mixed-citation><mixed-citation xml:lang="en">Trofimova A.G. Assessment of awareness of parents of children with chronic kidney disease about the disease. Meditsina: teoriya i praktika. 2019; (4): 549. https://elibrary.ru/tnnstc (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Sebastião Y.V., Cooper J.N., Becknell B., Ching C.B., McLeod D.J. Prediction of kidney failure in children with chronic kidney disease and obstructive uropathy. Pediatr. Nephrol. 2021; 36(1): 111–8. https://doi.org/10.1007/s00467-020-04661-w</mixed-citation><mixed-citation xml:lang="en">Sebastião Y.V., Cooper J.N., Becknell B., Ching C.B., McLeod D.J. Prediction of kidney failure in children with chronic kidney disease and obstructive uropathy. Pediatr. Nephrol. 2021; 36(1): 111–8. https://doi.org/10.1007/s00467-020-04661-w</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Oda T., Yoshizawa N. Factors affecting the progression of infection-related glomerulonephritis to chronic kidney disease. Int. J. Mol. Sci. 2021; 22(2): 905. https://doi.org/10.3390/ijms22020905</mixed-citation><mixed-citation xml:lang="en">Oda T., Yoshizawa N. Factors affecting the progression of infection-related glomerulonephritis to chronic kidney disease. Int. J. Mol. Sci. 2021; 22(2): 905. https://doi.org/10.3390/ijms22020905</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Юрьев В.К., Соколова В.В. Оценка информированности родителей о правах ребенка в системе обязательного медицинского страхования. Педиатрия. Журнал им. Г.Н. Сперанского. 2019; 98(5): 213–8. https://elibrary.ru/tbibzi</mixed-citation><mixed-citation xml:lang="en">Yur’ev V.K., Sokolova V.V. Assessment of parental awareness of children’s rights in the system of compulsory health insurance. Pediatriya. Zhurnal im. G.N. Speranskogo. 2019; 98(5): 213–8. https://elibrary.ru/tbibzi (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">He G., Li C., Wang S., Wang H., Ding J. Association of insurance status with chronic kidney disease stage at diagnosis in children. Pediatr. Nephrol. 2022; 37(11): 2705–14. https://doi.org/10.1007/s00467-022-05493-6</mixed-citation><mixed-citation xml:lang="en">He G., Li C., Wang S., Wang H., Ding J. Association of insurance status with chronic kidney disease stage at diagnosis in children. Pediatr. Nephrol. 2022; 37(11): 2705–14. https://doi.org/10.1007/s00467-022-05493-6</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Нестеренко О.В., Горемыкин В.И., Елизарова С.Ю., Сидорович О.В., Хижняк А.В. Влияние хронической болезни почек на качество жизни детей. Успехи современного естествознания. 2015; 9(2): 223–5. https://elibrary.ru/vbrzrx</mixed-citation><mixed-citation xml:lang="en">Nesterenko O.V., Goremykin V.I., Elizarova S.Yu., Sidorovich O.V., Khizhnyak A.V. The influence of chronic kidney disease on the quality of life of children. Uspekhi sovremennogo estestvoznaniya.2015; 9(2): 223–5. https://elibrary.ru/vbrzrx (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Beng-Ongey H., Robinson J.S., Moxey-Mims M. Chronic kidney disease emerging trends in children and what to do about it. J. Natl. Med. Assoc. 2022; 114(3S2): S50–5. https://doi.org/10.1016/j.jnma.2022.05.002</mixed-citation><mixed-citation xml:lang="en">Beng-Ongey H., Robinson J.S., Moxey-Mims M. Chronic kidney disease emerging trends in children and what to do about it. J. Natl. Med. Assoc. 2022; 114(3S2): S50–5. https://doi.org/10.1016/j.jnma.2022.05.002</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Schijvens A.M., de Wildt S.N., Schreuder M.F. Pharmacokinetics in children with chronic kidney disease. Pediatr. Nephrol. 2020; 35(7): 1153–72. https://doi.org/10.1007/s00467-019-04304-9</mixed-citation><mixed-citation xml:lang="en">Schijvens A.M., de Wildt S.N., Schreuder M.F. Pharmacokinetics in children with chronic kidney disease. Pediatr. Nephrol. 2020; 35(7): 1153–72. https://doi.org/10.1007/s00467-019-04304-9</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
