rospedРоссийский педиатрический журнал имени М.Я. СтуденикинаM.Ya. Studenikin Russian Pediatric JournalФГАУ «НМИЦ здоровья детей» Минздрава России10.46563/1560-9561-2023-26-2-140-144mynqrurosped-25Research ArticleОБЗОРЫREVIEWSРепродуктивные исходы у девочек-подростов с воспалительными заболеваниями органов малого тазаReproductive outcomes in adolescent girls with inflammatory diseases of the pelvic organshttps://orcid.org/0000-0002-3253-4512АдамянЛейла ВладимировнаAdamyanLeila V.

Доктор мед. наук, проф., акад. РАН, гл. специалист по гинекологии Минздрава России, зав. каф. репродуктивной медицины и хирургии ФПДО «МГМСУ им. А.И. Евдокимова»

e-mail: detskgyn@yandex.ru

endogyn@yandex.ruhttps://orcid.org/0000-0002-4540-6341СибирскаяЕлена ВикторовнаSibirskayaElena V.

Доктор мед. наук, проф. каф. репродуктивной медицины и хирургии ФПДО МГМСУ, гл. внештатный специалист — гинеколог детского и юношеского возраста Московской области, зав. гинекологическим отд-нием РДКБ ФГАОУ ВО «РНИМУ им. Н.И. Пирогова» Минздрава России

e-mail: elsibirskaya@yandex.ru 

MD, PhD, DSci., Professor of the Department of reproductive medicine and surgery, Pirogov Russian National Research Medical University, Moscow, 119571, Russian Federation, Chief freelance specialist gynecologist of childhood and adolescence of the Moscow Region, Head of the Gynecological department of the Russian Children’s Clinical Hospital, Pirogov Russian National Research Medical University, Moscow, 119571, Russian Federation.

e-mail: elsibirskaya@yandex.ru 

elsibirskaya@yandex.ruhttps://orcid.org/0000-0002-9563-6815ШарковСергей МихайловичSharkovSergey M.

Доктор мед. наук, проф. каф. детской хирургии и урологии-андрологии им. проф. Л.П. Александрова, руководитель Московского городского Центра репродуктивного здоровья детей и подростков

e-mail: sharkov_s_m_1@staff.sechenov.ru

sharkov_s_m_1@staff.sechenov.ruhttps://orcid.org/0000-0001-9057-2827КирилловаЮлия АлександровнаKirillovaYuliya A.

Врач акушер-гинеколог, ОСП РДКБ ФГАОУ ВО «РНИМУ им. Н.И. Пирогова», Москва, Россия

e-mail: kafa_33@inbox.ru

kafa_33@inbox.ruhttps://orcid.org/0000-0002-6844-3321ПивазянЛаура ГоровнаPivazyanLaura G.

Ординатор 1 года, ФГБУ «НМИЦ АГП им. В.И. Кулакова» Минздрава России

e-mail: laurapivazyan98@gmail.com

laurapivazyan98@gmail.comhttps://orcid.org/0000-0002-3127-5440ЛошкареваМария АлександровнаLoshkarevaMaria A.

Студентка 6 курса, ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» Минздрава России (Сеченовский Университет)

e-mail: mary.loshkareva@mail.ru

mary.loshkareva@mail.ruhttps://orcid.org/0000-0002-3237-6446ДжаруллаеваЗаира УрановнаDzharullaevaZaira U.

Студентка 5 курса, ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» Минздрава России (Сеченовский Университет)

e-mail: dzharullaeva.z.u@mail.ru

dzharullaeva.z.u@mail.ruФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России; ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова» Минздрава РоссииMoscow State University of Medicine and Dentistry named after A.I. Evdokimov; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. KulakovФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России; Российская детская клиническая больница ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииMoscow State University of Medicine and Dentistry named after A.I. Evdokimov; Russian Children’s Clinical Hospital, Pirogov Russian National Research Medical UniversityГБУЗ «Морозовская детская клиническая больница» Департамента здравоохранения города Москвы; ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)Morozov Children’s Municipal Clinical Hospital; I.M. Sechenov First Moscow State Medical University (Sechenov University)Российская детская клиническая больница ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииRussian Children’s Clinical Hospital, Pirogov Russian National Research Medical UniversityФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова» Минздрава РоссииNational Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. KulakovФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)I.M. Sechenov First Moscow State Medical University (Sechenov University)202309082023232140144Copyright © Адамян Л.В., Сибирская Е.В., Шарков С.М., Кириллова Ю.А., Пивазян Л.Г., Лошкарева М.А., Джаруллаева З.У., 20232023Адамян Л.В., Сибирская Е.В., Шарков С.М., Кириллова Ю.А., Пивазян Л.Г., Лошкарева М.А., Джаруллаева З.У.Adamyan L.V., Sibirskaya E.V., Sharkov S.M., Kirillova Y.A., Pivazyan L.G., Loshkareva M.A., Dzharullaeva Z.U.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rosped.ru/jour/article/view/25Введение

Введение. Воспалительные заболевания органов малого таза (ВЗОМТ) являются распространёнными формами патологии, которые часто сопровождаются серьёзными осложнениями.

Цель

Цель: определить ведущие репродуктивные исходы у девочек-подростков после перенесённых воспалительных заболеваний органов малого таза.

Материалы и методы

Материалы и методы. Обзор основан на анализе особенностей течения ВЗОМТ и влияния их осложнений на репродуктивную функцию девочек-подростков. Проведён поиск в базах данных PubMed и Cochrane Library глубиной 5 лет.

Результаты

Результаты. Установлено, что наибольшая частота встречаемости ВЗОМТ у девочек-подростков приходится на возраст 15–19 лет в связи с ранним началом половой жизни, отсутствием эффективной контрацепции и наличием нескольких часто инфицированных партнеров. Ведущими исходами ВЗОМТ у девочек-подростков являются рецидивирующие инфекции, хроническая тазовая боль, гнойные осложнения (сальпингиты, пиосальпинкс, тубоовариальный абсцесс), эктопическая беременность, преждевременные роды, эндометриоз и бесплодие. Выявлено, что отсутствие половой жизни не исключает возникновения ВЗОМТ и его осложнений у девочек. Это обусловлено состоянием иммунной защиты от инфекционных патогенов у девочек, а также качественным и количественным составом микробиоты половых путей. Поэтому так необходимы организация и проведение широкого скрининга подростков на наличие инфекций, передаваемых половым путём, для предупреждения их негативного влияния на фертильность юношей и девушек, а также эффективное обучение подростков по всем значимым вопросам репродуктивного здоровья.

Участие авторов

Участие авторов:Адамян Л.В., Сибирская Е.В. — концепция и дизайн исследования;Пивазян Л.Г., Лошкарева М.А., Джаруллаева З.У. — сбор и обработка материала;Кириллова Ю.А., Лошкарева М.А. — написание текста;Адамян Л.В., Сибирская Е.В., Шарков С.М. — редактирование.Все соавторы — утверждение окончательного варианта статьи, ответственность за целостность всех частей статьи.

Финансирование

Финансирование. Исследование не имело финансовой поддержки.

Конфликт интересов

Конфликт интересов. Авторы подтверждают отсутствие конфликта интересов.

Поступила 10

Поступила 10.02.2023Принята к печати 21.03.2023Опубликована 28.04.2023

Introduction

Introduction. Inflammatory diseases of the pelvic organs (IDPO) are common forms of pathology, which are often accompanied by serious complications.

Aim

Aim: to determine the leading reproductive outcomes in adolescent girls with IDPO.

Materials and methods

Materials and methods. The review is based on the analysis of the features of the course of IDPO and the impact of their complications on the reproductive function of adolescent girls. A search was conducted in the PubMed and Cochrane Library databases with a depth of 5 years.

Results

Results. It has been established that the highest incidence of IDPO in adolescent girls is at the age of 15–19 years due to the early onset of sexual activity, the lack of effective contraception and the presence of several frequently infected partners. Recurrent infections, chronic pelvic pain, purulent complications (salpingitis, pyosalpinx, tubo-ovarian abscess), ectopic pregnancy, premature birth, endometriosis and infertility are the leading outcomes of IDPO in adolescent girls. It was revealed that the absence of sexual activity does not exclude the occurrence of IDPO and its complications in girls. This is due to the state of immune protection against infectious pathogens in girls, and the qualitative and quantitative composition of the microbiota of the genital tract. Therefore, it is so necessary to manage and conduct a wide screening of adolescents for the presence of sexually transmitted infections to prevent their negative impact on the fertility of young males and females, and  effective training of adolescents on all significant issues of reproductive health.

Contribution

Contribution:Adamyan L.V., Sibirskaya E.V. — concept and design of the study;Pivazyan L.G., Loshkareva M.A. Dzharullayeva Z.U. — collection and processing of the material;Kirillova Yu.A., Loshkareva M.A. — writing the text;Adamyan L.V., Sibirskaya E.V., Sharkov S.M. — editing.All co-authors — approval of the final version of the article, responsibility for the integrity of all parts of the article.

Acknowledgment

Acknowledgment. The study had no sponsorship.

Conflict of interest

Conflict of interest. The authors declare no conflict of interest.

Received

Received: February 10, 2023Accepted: March 21, 2023Published: April 28, 2023

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The authors declare that there are no conflicts of interest present.