rospedРоссийский педиатрический журнал имени М.Я. СтуденикинаM.Ya. Studenikin Russian Pediatric JournalФГАУ «НМИЦ здоровья детей» Минздрава России10.46563/1560-9561-2023-26-1-22-26okwpxirosped-33Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL INVESTIGATIONSРотавирусная инфекция у детей: клинико-этиологическая структура и анализ вакцинопрофилактикиRotavirus infection in children: clinical and etiological structure and analysis of vaccine prophylaxishttps://orcid.org/0000-0003-3248-5519СутовскаяДиана ВладимировнаSutovskayaDiana V.

Доцент каф. педиатрии № 2, ФГБОУ ВО КГМУ Минздрава России.

e-mail: dsutovskaya@bk.ru

MD, PhD, Associate Professor of the Department of Pediatrics No. 2, Kuban State Medical University of the Ministry of Health of the Russian Federation, Krasnodar, 350063, Russian Federation.

e-mail: dsutovskaya@bk.ru

dsutovskaya@bk.ruhttps://orcid.org/0000-0002-9653-6365БурлуцкаяАлла ВладимировнаBurlutskayaAlla V.

Доктор мед. наук, зав. каф. педиатрии № 2 ФГБОУ ВО КГМУ Минздрава России.

e-mail: alvlad55@mail.ru

alvlad55@mail.ruhttps://orcid.org/0000-0002-2957-3203КрыловаДарья РомановнаKrylovaDaria R.

Клинический ординатор, ФГБОУ ВО КГМУ Минздрава России.

e-mail: crylovad@mail.ru

crylovad@mail.ruhttps://orcid.org/0000-0002-4425-506XТетенковаАнастасия АнатольевнаTetenkovaAnastasia A.

Гл. врач ГБУЗ ДГКБ МЗ Краснодарского края.

e-mail: Koppa@mail.ru

Koppa@mail.ruhttps://orcid.org/0000-0003-2373-4480ЛитвинскаяМарина АлександровнаLitvinskayaMarina A.

Канд. мед. наук, заместитель гл. врача ГБУЗ ДГКБ МЗ Краснодарского края.

e-mail: ma-litvinskaya@yandex.ru

ma-litvinskaya@yandex.ruhttps://orcid.org/0000-0002-5169-5952НауменкоГалина ВикторовнаNaumenkoGalina V.

Канд. мед. наук, ассистент каф. педиатрии № 2 ФГБОУ ВО КГМУ Минздрава России, зав. педиатрическим отд-нием ГБУЗ ДГКБ МЗ Краснодарского края.

e-mail: bolusalbae@mail.ru

bolusalbae@mail.ruhttps://orcid.org/0000-0002-3937-0477ЕпинетоваАлена АбдусаттаровнаEpinetovaAlena A.

Клинический ординатор, ФГБОУ ВО КГМУ Минздрава России.

e-mail: epinetova.a@yandex.ru

epinetova.a@yandex.ruФГБОУ ВО «Кубанский государственный медицинский университет» Минздрава РоссииKuban State Medical UniversityГБУЗ «Детская городская клиническая больница» г. Краснодар Минздрава Краснодарского краяChildren’s City Clinical HospitalФГБОУ ВО «Кубанский государственный медицинский университет» Минздрава России; ГБУЗ «Детская городская клиническая больница» г. Краснодар Минздрава Краснодарского краяKuban State Medical University; Children’s City Clinical Hospital2023070920232612226Copyright © Сутовская Д.В., Бурлуцкая А.В., Крылова Д.Р., Тетенкова А.А., Литвинская М.А., Науменко Г.В., Епинетова А.А., 20232023Сутовская Д.В., Бурлуцкая А.В., Крылова Д.Р., Тетенкова А.А., Литвинская М.А., Науменко Г.В., Епинетова А.А.Sutovskaya D.V., Burlutskaya A.V., Krylova D.R., Tetenkova A.A., Litvinskaya M.A., Naumenko G.V., Epinetova A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rosped.ru/jour/article/view/33Введение

Введение. Среди госпитализаций детей с острой кишечной инфекцией (ОКИ) 20–60% случаев ассоциировано с ротавирусной инфекцией (РВИ).

Цель работы — определить клинико-этиологическую структуру РВИ у госпитализированных детей и оценить состояние вакцинопрофилактики.

Материалы и методы

Материалы и методы. Проведён одномоментный ретроспективный анализ 505 историй болезни детей (267 мальчиков и 238 девочек) в возрасте 0–18 лет, госпитализированных в 2020 г. в ГБУЗ «Детская городская клиническая больница» г. Краснодара с ОКИ. Изучено состояние вакцинопрофилактики (2013–2020 гг.) на базе Центра вакцинопрофилактики г. Краснодара.

Результаты

Результаты. Число иммунизированных детей составило 6552 и увеличилось с 10 в 2013 г. до 1460 в 2020 г. Охват вакцинацией в 2020 г. составил 5,9% целевой когорты. Установлено менее 1% побочных проявлений после иммунизации. В структуре ОКИ зарегистрировано 140 (27,7%) случаев РВИ: моно-РВИ — 50 (35,7%), микст-РВИ — 90 (64,3%). Среди микст-РВИ выявлены норо-РВИ (67,9% случаев), норо-адено-РВИ (17,8%), адено-РВИ (3,3%), сальмонелёзно-норо-РВИ (3,3%), сальмонелёзно-РВИ, сальмонелёзно-норо-адено-РВИ и кампилобактериально-норо-РВИ — по 2,2%, ешерихио-РВИ (1,1%). Возрастная структура пациентов с РВИ: дети до 1 года (59,3%), 1–3 года (21,4%), 4–6 лет (7,2%), 7–18 лет (12,1%). Моно-РВИ встречалась в виде гастроэнтерита в среднетяжелой (78%) и тяжёлой (22%) формах с различной степенью выраженности обезвоживания (I степень — 74%, II степень — 4%, III степень — 22%). Микст-РВИ встречалась в виде гастроэнтерита 80 (88,9%) и энтероколита 10 (11,1%) в среднетяжёлой (81%) и тяжёлой (19%) формах с эксикозом I (63%), II (18%) и III (19%) степени. Ни один госпитализированный ребёнок не был привит против РВИ.

Заключение

Заключение. Высокая интенсивность распространения эпидемического процесса при РИ свидетельствует о необходимости широкого внедрения вакцинации.

Участие авторов

Участие авторов:Сутовская Д.В., Бурлуцкая А.В. — концепция и дизайн исследования, редактирование;Сутовс­кая Д.В., Тетенкова А.А., Литвинская М.А., Науменко Г.В. — сбор и обработка материала;Сутовская Д.В., Епинетова А.А. — статистическая обработка;Сутовская Д.В., Крылова Д.Р. — написание текста.Все соавторы — утверждение окончательного варианта статьи, ответственность за целостность всех частей статьи.

Финансирование

Финансирование. Исследование не имело финансовой поддержки.

Конфликт интересов

Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов. 

Поступила 19

Поступила 19.12.2022Принята к печати 17.01.2023Опубликована 28.02.2023

Among all hospitalizations of children with acute enteral infection (AEI), 20 to 60% are associated with rotavirus infection (RVI). The high intensity of the spread of the epidemic process and mortality from RVI indicates to the need for vaccination.

Aim

Aim: to assess the state of vaccination and study the clinical and etiological structure of RVI in children in-patients in the city of Krasnodar.

Materials and methods

Materials and methods. There was performed the single-stage retrospective analysis of 505 case histories of acute AEI 0–18 years children (boys/girls: 267/238) admitted to the Children’s City Clinical Hospital in Krasnodar (2020). The state of vaccination (2013–2020) was studied on the base of the vaccination center in the Children’s City Clinical Hospital in Krasnodar.

Results

Results. The number of immunized 6552 increased from 10 (2013) to 1460 (2020). Vaccination coverage in 2020 was 5.9% of the target cohort. Less than 1% of adverse events after immunization have been reported. In the AEI structure, 140 cases of RVI (27.7%) were registered: mono-RVI 50 (35.7%), mixed-RVI 90 (64.3%). Mixed-RVI included noro-RVI (67.9% cases), noro-adeno-RVI (17.8%), adeno-RVI (3.3%), salmonella-noro-RVI (3.3%), salmonella-RVI, salmonella-noro-adeno-RVI, campylobacteria-noro-RVI (2.2%) and escherichio-RVI (1.1%). The age structure of the Republic of Ingushetia was dominated by children under 1 year — 59.3%, 1–3 years old — 21.4%, 4–6 years old — 7.2%, 7–18 years old — 12.1%. Mono-RVI occurred in the form of gastroenteritis in moderate (78%) and severe (22%) forms with varying degrees of dehydration (stage I — 74%, stage II — 4%, stage III — 22%). Mixed RVI occurred in the form of gastroenteritis 80 (88.9%) and enterocolitis 10 (11.1%) in moderate (81%) and severe (19%) forms with stage I exsicosis (63%), II Art. (18%), III Art. (19%). Among all hospitalized children, none were as vaccinated against RVI.

Conclusion

Conclusion. The high intensity of the spread of the epidemic process in RVI indicates the need for vaccination.

Contribution

Contribution:Sutovskaya D.V., Burlutskaya A.V. — the concept and design of the study;Sutovskaya D.V., Tetenkova A.A., Litvinskaya M.A., Naumenko G.V. — collection and processing of material;Sutovskaya D.V., Epinetova A.A. — statistical processing;Sutovskaya D.V., Krylova D.R. — writing the text;Sutovskaya D.V., Burlutskaya A.V. — editing.All co-authors — approval of the final version of the article, responsibility for the integrity of all parts of the article.

Acknowledgment

Acknowledgment. The study had no sponsorship.

Conflict of interest

Conflict of interest. The authors declare no conflict of interest.

Received

Received: December 19, 2022Accepted: January 17, 2023Published: February 28, 2023

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The authors declare that there are no conflicts of interest present.