rospedРоссийский педиатрический журнал имени М.Я. СтуденикинаM.Ya. Studenikin Russian Pediatric JournalФГАУ «НМИЦ здоровья детей» Минздрава России10.46563/1560-9561-2022-25-3-199-205ilnzdzrosped-331Research ArticleОБЗОРЫREVIEWSВитамин D и COVID-19. Два года исследованийVitamin D and COVID-19. Two years of researchhttps://orcid.org/0000-0001-8586-7946ФисенкоАндрей ПетровичFisenkoAndrey P.

Доктор мед. наук, проф., директор ФГАУ «НМИЦ здоровья детей» Минздрава России.

e-mail: director@nczd.ru

director@nczd.ruhttps://orcid.org/0000-0002-3056-403XМакароваСветлана ГеннадиевнаMakarovaSvetlana G.

Доктор мед. наук, руководитель центра профилактической педиатрии ФГАУ «НМИЦ здоровья детей» Минздрава России; проф. каф. многопрофильной клинической подготовки факультета фундаментальной медицины ФГБОУ ВО «МГУ им. М.В. Ломоносова».

e-mail: sm27@yandex.ru

Head of the Department of preventive pediatrics of National Medical Research Center for Children’s Health, professor of the Department of Multidisciplinary Clinical Training, Faculty of Fundamental Medicine.

e-mail: sm27@yandex.ru

sm27@yandex.ruhttps://orcid.org/0000-0003-1330-2828ЯсаковДмитрий СергеевичYasakovDmitry S.

Канд. мед. наук, ст. науч. сотр. отдела профилактической педиатрии ФГАУ «НМИЦ здоровья детей» Мин­здрава России.

e-mail: dmyasakov@mail.ru

dmyasakov@mail.ruhttps://orcid.org/0000-0003-3306-6869ПронинаИрина ЮрьевнаProninaIrina Yu.

Мл. науч. сотр. отдела профилактической педиатрии ФГАУ «НМИЦ здоровья детей» Минздрава России; врач-эндокринолог, ФГБУ «НМИЦ эндокринологии» Минздрава России.

e-mail: krapchatovaiv@yandex.ru

krapchatovaiv@yandex.ruhttps://orcid.org/0000-0002-1650-652XЕрешкоОксана АлександровнаEreshkoOksana A.

Канд. мед. наук, ст. науч. сотр. отдела профилактической педиатрии ФГАУ «НМИЦ здоровья детей» Мин­здрава России.

e-mail: ksenya2005@inbox.ru

ksenya2005@inbox.ruhttps://orcid.org/0000-0001-6658-0624ГордееваИрина ГригорьевнаGordeevaIrina G.

Мл. науч. сотр. отдела профилактической педиатрии ФГАУ «НМИЦ здоровья детей» Минздрава России.

e-mail: irifeen@yandex.ru

irifeen@yandex.ruhttps://orcid.org/0000-0002-6701-3872ГалимоваАльбина АльбертовнаGalimovaAlbina A.

Мл. науч. сотр. отдела профилактической педиатрии ФГАУ «НМИЦ здоровья детей» Минздрава России.

e-mail: al-bina86@yandex.ru

al-bina86@yandex.ruhttps://orcid.org/0000-0002-8172-5710ЧумбадзеТамара РобертовнаChumbadzeTamara R.

Канд. мед. наук, ст. науч. сотр. отдела профилактической педиатрии ФГАУ «НМИЦ здоровья детей» Минздрава России.

e-mail: tamararob@rambler.ru

tamararob@rambler.ruhttps://orcid.org/0000-0002-0995-4260ЕмельяшенковЕвгений ЕвгеньевичEmelyashenkovEvgeny Е.

Аспирант ФГАУ «НМИЦ здоровья детей» Минздрава России.

e-mail: dkswdsman@mail.ru

dkswdsman@mail.ruhttps://orcid.org/0000-0001-6469-0766ЛебедеваАйина МихайловнаLebedevaAyina M.

Лаборант отдела профилактической педиатрии ФГАУ «НМИЦ здоровья детей» Минздрава России, аспирант ФГБУН «ФИЦ питания и биотехнологии и безопасности пищи».

e-mail: lam_95@mail.ru

lam_95@mail.ruФГАУ «Национальный медицинский исследовательский центр здоровья детей»National Medical Research Center for Children’s Health of the Ministry of Health of the Russian FederationФГАУ «Национальный медицинский исследовательский центр здоровья детей»; ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»National Medical Research Center for Children’s Health of the Ministry of Health of the Russian Federation; Lomonosov Moscow State UniversityФГАУ «Национальный медицинский исследовательский центр здоровья детей»; ФГБУ «Национальный медицинский исследовательский центр эндокринологии»National Medical Research Center for Children’s Health of the Ministry of Health of the Russian Federation; National Medical Research Center of EndocrinologyФГАУ «Национальный медицинский исследовательский центр здоровья детей»; ФГБУН «Федеральный исследовательский центр питания, биотехнологии и безопасности пищи»National Medical Research Center for Children’s Health of the Ministry of Health of the Russian Federation; Federal Research Centre of Nutrition, Biotechnology and Food Safety202227092023253199205Copyright © Фисенко А.П., Макарова С.Г., Ясаков Д.С., Пронина И.Ю., Ерешко О.А., Гордеева И.Г., Галимова А.А., Чумбадзе Т.Р., Емельяшенков Е.Е., Лебедева А.М., 20232023Фисенко А.П., Макарова С.Г., Ясаков Д.С., Пронина И.Ю., Ерешко О.А., Гордеева И.Г., Галимова А.А., Чумбадзе Т.Р., Емельяшенков Е.Е., Лебедева А.М.Fisenko A.P., Makarova S.G., Yasakov D.S., Pronina I.Y., Ereshko O.A., Gordeeva I.G., Galimova A.A., Chumbadze T.R., Emelyashenkov E.Е., Lebedeva A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rosped.ru/jour/article/view/331

Важное значение микронутриентного статуса организма для формирования адекватного иммунного ответа, в том числе на респираторные вирусы, не вызывает сомнений. С началом пандемии, вызванной SARS-CoV-2, появились многочисленные публикации, посвящённые предположительно защитному влиянию ряда микронутриентов, в особенности витамина D, в отношении профилактики заболевания COVID-19. С 2020 г. до начала 2022 г. было опубликовано около 20 аналитических обзоров и метаанализов, суммирующих результаты различных исследований, оценивающих как профилактический потенциал обеспеченности витамином D различных групп населения, так и роль витамина D в снижении частоты тяжёлых форм COVID-19 и смертности. Приведённый в данном обзоре анализ данных свидетельствует о том, что витамин D является микронутриентом, способствующим снижению риска формирования тяжёлых форм COVID-19, и обладает наибольшей доказательной базой. Приводятся актуальные рекомендации по дотации витамина D, в том числе детям.

Участие авторовМакарова С.Г., Ясаков Д.С. — концепция и дизайн исследования; Пронина И.Ю., Ерешко О.А., Гордеева И.Г., Галимова А.А., Чумбадзе Т.Р., Емельяшенков Е.Е., Лебедева А.М. — сбор и обработка материала;Макарова С.Г., Ясаков Д.С. — написание текста;Фисенко А.П. — редактирование.Все соавторы — утверждение окончательного варианта статьи, ответственность за целостность всех частей статьи.

Финансирование

Финансирование. Исследование не имело финансовой поддержки.

Конфликт интересов

Конфликт интересов. Авторы подтверждают отсутствие конфликта интересов.

Поступила 15

Поступила 15.04.2022Принята к печати 10.06.2022Опубликована 07.05.2022

The important role of the micronutrient status of the body for the formation of an adequate immune response, including to respiratory viruses, is currently beyond doubt. In connection with the beginning of the pandemic caused by SARS-CoV-2, numerous publications have appeared on the supposedly protective effect of many micronutrients, especially vitamin D in relation to the prevention of COVID-19 disease. Later, the results of most studies confirmed this assumption. From 2020 to early 2022, there were published 17 analytical reviews and meta-analyses summarizing the results of various studies evaluating both the preventive potential of vitamin D provision in various population groups and the role of vitamin D in reducing the incidence of severe forms of COVID-19 and mortality. The analysis of literature data presented in this review suggests vitamin D currently to have the greatest evidence base as a micronutrient promoting reduction the risk of disease and severe forms of COVID-19. Current recommendations on vitamin D subsidies, including in pediatric practice, are given.

Contribution

Contribution:Makarova S.G., Yasakov D.S. — research concept and design of the study;Pronina I.Yu., Ereshko O.A., Gordeeva I.G., Galimova A.A., Chumbadze T.R., Emelyashenkov E.E., Lebedeva A.M. — collection and processing of material; Makarova S.G., Yasakov D.S. — text writing; Fisenko A.P. — editing.All co-authors — approval of the final version of the article, responsibility for the integrity of all parts of the article.

Acknowledgment

Acknowledgment. The study had no sponsorship.

Conflict of interest

Conflict of interest. The authors declare no conflict of interest.

Received

Received: April 15, 2022Accepted:  June 10, 2022Published: May 07, 2022

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The authors declare that there are no conflicts of interest present.