rospedРоссийский педиатрический журнал имени М.Я. СтуденикинаM.Ya. Studenikin Russian Pediatric JournalФГАУ «НМИЦ здоровья детей» Минздрава России10.46563/1560-9561-2022-25-3-206-211yobfgyrosped-332Research ArticleОБЗОРЫREVIEWSЦистатин С и липокалин — эндогенные маркёры клубочковой фильтрации у детей, родившихся недоношеннымиCystatin C and lipocalin — endogenous markers of glomerular filtration in children born prematurelyhttps://orcid.org/0000-0002-8021-9592ЦинцадзеБелла ДжемалиевнаTsintsadzeBella D.

Аспирант отделения патологии раннего детского возраста ФГАУ «НМИЦ здоровья детей» Минздрава России.

e-mail: tsintsadze.bd@nczd.ru

Postgraduate student of the Department of early childhood pathology, National Medical Research Center for Children’s Health, Moscow, 119991, Russian Federation.

e-mail: tsintsadze@nczd.ru

tsintsadze.bd@nczd.ruФГАУ «Национальный медицинский исследовательский центр здоровья детей» Минздрава РоссииNational Medical Research Center for Children’s Health202227092023253206211Copyright © Цинцадзе Б.Д., 20232023Цинцадзе Б.Д.Tsintsadze B.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rosped.ru/jour/article/view/332

Необходимость поиска новых маркеров функционального состояния почек увеличивается в связи с ростом числа глубоко недоношенных новорождённых. В обзоре проведён анализ публикаций, посвящённых возможностям оценки функции почек с помощью цистатина С и липокалина у детей, рождённых недоношенными. Постоянная скорость продукции цистатина С во всех тканях, его элиминация через почечный клубочковый фильтр, отсутствие секреции в проксимальных канальцах, а также независимость от многих факторов, включая пол, возраст, диету, воспаление, являются идеальными условиями для его использования в качестве эндогенного биохимического маркера клубочковой фильтрации. Установлено, что за счёт биохимических особенностей анализ сывороточных уровней цистатина С является перспективным методом в диагностике острого почечного повреждения у недоношенных новорождённых. Для комплексной оценки функций почек у недоношенных детей может иметь значение совместное одновременное определение уровней липокалина и цистатина С в крови. При этом оценка данных показателей может иметь диагностическую значимость в прогнозировании развития хронической болезни почек у детей, перенёсших в младенчестве острое повреждение почек. Сделан вывод, что отсутствие референсных значений липокалина и цистатина С у недоношенных детей сдерживает клиническое использование их количественного анализа для комплексной оценки функционального состояния почек. 

Финансирование

Финансирование. Исследование не имело финансовой поддержки.

Конфликт интересов

Конфликт интересов. Автор заявляет об отсутствии конфликта интересов.

Поступила 18

Поступила 18.05.2022Принята к печати 10.06.2022Опубликована 14.07.2022

The need to search for new markers of the functional state of the kidneys is increasing due to the gain in the number of extremely premature infants. The review analyzes publications on the possibilities of assessing kidney function using cystatin C and lipocalin in children born prematurely. The constant rate of cystatin C production in all tissues, its elimination through the renal glomerular filter, the absence of secretion in the proximal tubules, as well as independence from many factors, including gender, age, diet, inflammation are ideal conditions for its use as an endogenous biochemical marker of glomerular filtration. Due to biochemical features, the analysis of serum levels of cystatin C was established to be a promising method in the diagnosis of acute renal injury (AKI) in premature infants. For a comprehensive assessment of kidney function in premature infants, simultaneous determination of lipocalin and cystatin C levels in the blood may be important. At the same time, the evaluation of these indicators may have diagnostic significance in predicting the development of chronic kidney disease in children who underwent AKI in infancy. The absence of reference values of lipocalin and cystatin C in premature infants was concluded to hinder the clinical use of their quantitative analysis for a comprehensive assessment of the functional state of the kidneys.

Acknowledgment

Acknowledgment. The study had no sponsorship.

Conflict of interest

Conflict of interest. The author has declared that there are no conflicts of interest

Received

Received: May 18, 2022Accepted: June 10, 2022Published: July 14, 2022

детинедоношенныецистатин С кровилипокалинострое почечное повреждениехроническая болезнь почекchildrenpremature infantscystatin from bloodlipocalin (NGAL)acute renal injurychronic kidney diseaseReferencesChaturvedi S., Ng K.H., Mammen C. The path to chronic kidney disease following acute kidney injury: a neonatal perspective. Pediatr. Nephrol. 2017; 32(2) 227-41. https://doi.org/10.1007/s00467-015-3298-9Chaturvedi S., Ng K.H., Mammen C. The path to chronic kidney disease following acute kidney injury: a neonatal perspective. Pediatr. Nephrol. 2017; 32(2) 227–41. https://doi.org/10.1007/s00467-015-3298-9Duzova A., Bakkaloglu A., Kalyoncu M., Poyrazoglu Y., Delibas A., Ozkaya O., et al. Etiology and outcome of acute kidney injury in children. Pediatr. Nephrol. 2010; 25(8): 1453-61. https://doi.org/10.1007/s00467-010-1541-yDuzova A., Bakkaloglu A., Kalyoncu M., Poyrazoglu Y., Delibas A., Ozkaya O., et al. Etiology and outcome of acute kidney injury in children. Pediatr. Nephrol. 2010; 25(8): 1453–61. https://doi.org/10.1007/s00467-010-1541-yPiepsz A., Tondeur M., Ham H. Revisiting normal (51)Cr-ethylenediaminetetraacetic acid clearance values in children. Eur. J. Nucl. Med. Mol. Imaging. 2006; 33(12): 1477-82. https://doi.org/10.1007/s00259-006-0179-2Piepsz A., Tondeur M., Ham H. Revisiting normal (51)Cr-ethylenediaminetetraacetic acid clearance values in children. Eur. J. Nucl. Med. Mol. Imaging. 2006; 33(12): 1477–82. https://doi.org/10.1007/s00259-006-0179-2Faa G., Gerosa C., Fanni D., Nemolato S., Locci A., Cabras T., et al. Marked interindividual variability in renal maturation of preterm infants: lessons from autopsy. J. Matern. Fetal. Neonatal. Med. 2010; 23(Suppl. 3): 129-33. https://doi.org/10.3109/14767058.2010.510646Faa G., Gerosa C., Fanni D., Nemolato S., Locci A., Cabras T., et al. Marked interindividual variability in renal maturation of preterm infants: lessons from autopsy. J. Matern. Fetal. Neonatal. Med. 2010; 23(Suppl. 3): 129–33. https://doi.org/10.3109/14767058.2010.510646Rodríguez M.M., Gómez A.H., Abitbol C.L., Chandar J.J., Duara S., Zilleruelo G.E. Histomorphometric analysis of postnatal glomerulogenesis in extremely preterm infants. Pediatr. Dev. Pathol. 2004; 7(1): 17-25. https://doi.org/10.1007/s10024-003-3029Rodríguez M.M., Gómez A.H., Abitbol C.L., Chandar J.J., Duara S., Zilleruelo G.E. Histomorphometric analysis of postnatal glomerulogenesis in extremely preterm infants. Pediatr. Dev. Pathol. 2004; 7(1): 17–25. https://doi.org/10.1007/s10024-003-3029Iacobelli S., Guignard J.P. Maturation of glomerular filtration rate in neonates and infants: an overview. Pediatr. Nephrol. 2021; 36(6): 1439-46. https://doi.org/10.1007/s00467-020-04632-1Iacobelli S., Guignard J.P. Maturation of glomerular filtration rate in neonates and infants: an overview. Pediatr. Nephrol. 2021; 36(6): 1439–46. https://doi.org/10.1007/s00467-020-04632-1Branagan A., Costigan C.S., Stack M., Slagle C., Molloy E.J. Management of acute kidney injury in extremely low birth weight infants. Front. Pediatr. 2022; 10: 867715. https://doi.org/10.3389/fped.2022.867715Branagan A., Costigan C.S., Stack M., Slagle C., Molloy E.J. Management of acute kidney injury in extremely low birth weight infants. Front. Pediatr. 2022; 10: 867715. https://doi.org/10.3389/fped.2022.867715Kuo J., Akison L.K., Chatfield M.D., Trnka P., Moritz K.M. Serum and urinary biomarkers to predict acute kidney injury in premature infants: a systematic review and meta-analysis of diagnostic accuracy. J. Nephrol. 2022. https://doi.org/10.1007/s40620-022-01307-yKuo J., Akison L.K., Chatfield M.D., Trnka P., Moritz K.M. Serum and urinary biomarkers to predict acute kidney injury in premature infants: a systematic review and meta-analysis of diagnostic accuracy. J. Nephrol. 2022. https://doi.org/10.1007/s40620-022-01307-yRanders E., Krue S., Erlandsen E.J., Danielsen H., Hansen L.G. Reference interval for serum cystatin C in children. Clin. Chem. 1999; 45(10): 1856-8.Randers E., Krue S., Erlandsen E.J., Danielsen H., Hansen L.G. Reference interval for serum cystatin C in children. Clin. Chem. 1999; 45(10): 1856–8.Barrett A.J., Davies M.E., Grubb A. The place of human γ-trace (cystatin C) amongst the cysteine proteinase inhibitors. Biochem. Biophy. Res.Commun. 1984; 120(2): 631-6. https://doi.org/10.1016/0006-291x(84)91302-0Barrett A.J., Davies M.E., Grubb A. The place of human γ-trace (cystatin C) amongst the cysteine proteinase inhibitors. Biochem. Biophy. Res. Commun. 1984; 120(2): 631–6. https://doi.org/10.1016/0006-291x(84)91302-0Grubb A., Löfberg H. Human gamma-trace, a basic microprotein: amino acid sequence and presence in the adenohypophysis. Proc. Natl. Acad. Sci. USA. 1982; 79(9): 3024-7. https://doi.org/10.1073/pnas.79.9.3024Grubb A., Löfberg H. Human gamma-trace, a basic microprotein: amino acid sequence and presence in the adenohypophysis. Proc. Natl. Acad. Sci. USA. 1982; 79(9): 3024–7. https://doi.org/10.1073/pnas.79.9.3024Simonsen O., Grubb A., Thysell H. The blood serum concentration of cystatin C (γ-trace) as a measure of the glomerular filtration rate. Scand. J. Clin. Lab. Invest. 1985; 45(2): 97-101. https://doi.org/10.3109/00365518509160980Simonsen O., Grubb A., Thysell H. The blood serum concentration of cystatin C (γ-trace) as a measure of the glomerular filtration rate. Scand. J. Clin. Lab. Invest. 1985; 45(2): 97–101. https://doi.org/10.3109/00365518509160980Hidayati E.L., Utami M.D., Rohsiswatmo R., Tridjaja B. Cystatin C compared to serum creatinine as a marker of acute kidney injury in critically ill neonates. Pediatr. Nephrol. 2021; 36(1): 181-6. https://doi.org/10.1007/s00467-020-04668-3Hidayati E.L., Utami M.D., Rohsiswatmo R., Tridjaja B. Cystatin C compared to serum creatinine as a marker of acute kidney injury in critically ill neonates. Pediatr. Nephrol. 2021; 36(1): 181–6. https://doi.org/10.1007/s00467-020-04668-3Grubb A. Cystatin C is indispensable for evaluation of kidney disease. EJIFCC. 2017; 28(4): 268-76.Grubb A. Cystatin C is indispensable for evaluation of kidney disease. EJIFCC. 2017; 28(4): 268–76.Hidayati E.L., Utami M.D., Rohsiswatmo R., Tridjaja B. Cystatin C compared to serum creatinine as a marker of acute kidney injury in critically ill neonates. Pediatr. Nephrol. 2021; 36(1): 181-6. https://doi.org/10.1007/s00467-020-04668-3Hidayati E.L., Utami M.D., Rohsiswatmo R., Tridjaja B. Cystatin C compared to serum creatinine as a marker of acute kidney injury in critically ill neonates. Pediatr. Nephrol. 2021; 36(1): 181–6. https://doi.org/10.1007/s00467-020-04668-3Shlipak M.G., Katz R., Sarnak M.J., Fried L.F., Newman A.B., Stehman-Breen C., et al. Cystatin C and prognosis for cardiovascular and kidney outcomes in elderly persons without chronic kidney disease. Ann.Intern. Med. 2006; 145(4): 237-46. https://doi.org/10.7326/0003-4819-145-4-200608150-00003Shlipak M.G., Katz R., Sarnak M.J., Fried L.F., Newman A.B., Stehman-Breen C., et al. Cystatin C and prognosis for cardiovascular and kidney outcomes in elderly persons without chronic kidney disease. Ann. Intern. Med. 2006; 145(4): 237–46. https://doi.org/10.7326/0003-4819-145-4-200608150-00003Kandasamy Y., Smith R., Wright I. M. Measuring cystatin C to determine renal function in neonates. Pediatr. Crit. Care Med. 2013; 14(3): 318-22. https://doi.org/10.1097/pcc.0b013e318271f4a5Kandasamy Y., Smith R., Wright I. M. Measuring cystatin C to determine renal function in neonates. Pediatr. Crit. Care Med. 2013; 14(3): 318–22. https://doi.org/10.1097/pcc.0b013e318271f4a5Ziegelasch N., Vogel M., Müller E., Tremel N., Jurkutat A., Löffler M., et al. Cystatin C serum levels in healthy children are related to age, gender, and pubertal stage. Pediatr. Nephrol. 2019; 34(3): 449-57. https://doi.org/10.1007/s00467-018-4087-zZiegelasch N., Vogel M., Müller E., Tremel N., Jurkutat A., Löffler M., et al. Cystatin C serum levels in healthy children are related to age, gender, and pubertal stage. Pediatr. Nephrol. 2019; 34(3): 449–57. https://doi.org/10.1007/s00467-018-4087-zSethi S.K., Bunchman T., Chakraborty R., Raina R. Pediatric acute kidney injury: new advances in the last decade. Kidney. Res. Clin. Pract. 2021; 40(1): 40-51. https://doi.org/10.23876/j.krcp.20.074Sethi S.K., Bunchman T., Chakraborty R., Raina R. Pediatric acute kidney injury: new advances in the last decade. Kidney. Res. Clin. Pract. 2021; 40(1): 40–51. https://doi.org/10.23876/j.krcp.20.074Uemura O., Ushijima K., Nagai T., Yamada T., Hayakawa H., Nabeta Y., et al. Reference serum cystatin C levels in Japanese children. Clin. Exp. Nephrol. 2010; 14(5): 453-6. https://doi.org/10.1007/s10157-010-0314-zUemura O., Ushijima K., Nagai T., Yamada T., Hayakawa H., Nabeta Y., et al. Reference serum cystatin C levels in Japanese children. Clin. Exp. Nephrol. 2010; 14(5): 453–6. https://doi.org/10.1007/s10157-010-0314-zHarmoinen A., Ylinen E., Ala-Houhala M., Janas M., Kaila M., Kouri T. Reference intervals for cystatin C in pre- and full-term infants and children. Pediatr. Nephrol. 2000; 15(1-2): 105-8. https://doi.org/10.1007/s004670000421Harmoinen A., Ylinen E., Ala-Houhala M., Janas M., Kaila M., Kouri T. Reference intervals for cystatin C in pre- and full-term infants and children. Pediatr. Nephrol. 2000; 15(1-2): 105–8. https://doi.org/10.1007/s004670000421Armangil D., Yurdakök M., Canpolat F.E., Korkmaz A., Yiğit S., Gülsevin T. Determination of reference values for plasma cystatin C and comparison with creatinine in premature infants. Pediatr. Nephrol. 2008; 23(11): 2081-3. https://doi.org/10.1007/s00467-008-0867-1Armangil D., Yurdakök M., Canpolat F.E., Korkmaz A., Yiğit S., Gülsevin T. Determination of reference values for plasma cystatin C and comparison with creatinine in premature infants. Pediatr. Nephrol. 2008; 23(11): 2081–3. https://doi.org/10.1007/s00467-008-0867-1Renganathan A., Warner B.B., Tarr P.I., Dharnidharka V.R. The progression of serum cystatin C concentrations within the first month of life after preterm birth-a worldwide systematic review. Pediatr. Nephrol. 2021; 36(7): 1709-18. https://doi.org/10.1007/s00467-020-04543-1Renganathan A., Warner B.B., Tarr P.I., Dharnidharka V.R. The progression of serum cystatin C concentrations within the first month of life after preterm birth-a worldwide systematic review. Pediatr. Nephrol. 2021; 36(7): 1709–18. https://doi.org/10.1007/s00467-020-04543-1Monzani A., Crespi I., Genoni G., Edefonti A., Montini G., Bellomo G., et al. Kidney-Detrimental factors and estimated glomerular filtration rate in preterm newborns: the role of nutrition. Nutrients. 2020; 12(3): 651. https://doi.org/10.3390/nu12030651Monzani A., Crespi I., Genoni G., Edefonti A., Montini G., Bellomo G., et al. Kidney-Detrimental factors and estimated glomerular filtration rate in preterm newborns: the role of nutrition. Nutrients. 2020; 12(3): 651. https://doi.org/10.3390/nu12030651Schwartz G.J., Schneider M.F., Maier P.S., Moxey-Mims M., Dharnidharka V.R., Bradley A., et al. Improved equations estimating GFR in children with chronic kidney disease using an immunonephelometric determination of cystatin C. Kidney.Int. 2012; 82(4): 445-53. https://doi.org/10.1038/ki.2012.169Schwartz G.J., Schneider M.F., Maier P.S., Moxey-Mims M., Dharnidharka V.R., Bradley A., et al. Improved equations estimating GFR in children with chronic kidney disease using an immunonephelometric determination of cystatin C. Kidney. Int. 2012; 82(4): 445–53. https://doi.org/10.1038/ki.2012.169Hasson D., Menon S., Gist K.M. Improving acute kidney injury diagnostic precision using biomarkers. Pract. Lab. Med. 2022; 30: e00272. https://doi.org/10.1016/j.plabm.2022.e00272Hasson D., Menon S., Gist K.M. Improving acute kidney injury diagnostic precision using biomarkers. Pract. Lab. Med. 2022; 30: e00272. https://doi.org/10.1016/j.plabm.2022.e00272Abitbol C.L., Seeherunvong W., Galarza M.G., Katsoufis C., Francoeur D., Defreitas M., et al. Neonatal kidney size and function in preterm infants: what is a true estimate of glomerular filtration rate? J. Pediatr. 2014; 164(5): 1026-31.e2. https://doi.org/10.1016/j.jpeds.2014.01.044Abitbol C.L., Seeherunvong W., Galarza M.G., Katsoufis C., Francoeur D., Defreitas M., et al. Neonatal kidney size and function in preterm infants: what is a true estimate of glomerular filtration rate? J. Pediatr. 2014; 164(5): 1026–31.e2. https://doi.org/10.1016/j.jpeds.2014.01.044Bardallo Cruzado L., Pérez González E., Martínez Martos Z., Bermudo Guitarte C., Granero Asencio M., Luna Lagares S., et al. Serum cystatin C levels in preterm newborns in our setting: Correlation with serum creatinine and preterm pathologies. Nefrologia. 2015; 35(3): 296-303. https://doi.org/10.1016/j.nefro.2015.05.004Bardallo Cruzado L., Pérez González E., Martínez Martos Z., Bermudo Guitarte C., Granero Asencio M., Luna Lagares S., et al. Serum cystatin C levels in preterm newborns in our setting: Correlation with serum creatinine and preterm pathologies. Nefrologia. 2015; 35(3): 296–303. https://doi.org/10.1016/j.nefro.2015.05.004Treiber M., Pecovnik-Balon B., Gorenjak M. Cystatin C versus creatinine as a marker of glomerular filtration rate in the newborn. Wien. Klin. Wochenschr. 2006; 118(Suppl. 2): 66-70. https://doi.org/10.1007/s00508-006-0555-8Treiber M., Pecovnik-Balon B., Gorenjak M. Cystatin C versus creatinine as a marker of glomerular filtration rate in the newborn. Wien. Klin. Wochenschr. 2006; 118(Suppl. 2): 66–70. https://doi.org/10.1007/s00508-006-0555-8Nakhjavan-Shahraki B., Yousefifard M., Ataei N., Baikpour M., Ataei F., Bazargani B., et al. Accuracy of cystatin C in prediction of acute kidney injury in children; serum or urine levels: which one works better? A systematic review and meta-analysis. BMC Nephrol. 2017; 18(1): 120. https://doi.org/10.1186/s12882-017-0539-0Nakhjavan-Shahraki B., Yousefifard M., Ataei N., Baikpour M., Ataei F., Bazargani B., et al. Accuracy of cystatin C in prediction of acute kidney injury in children; serum or urine levels: which one works better? A systematic review and meta-analysis. BMC Nephrol. 2017; 18(1): 120. https://doi.org/10.1186/s12882-017-0539-0Hidayati E.L., Utami M.D., Rohsiswatmo R., Tridjaja B. Cystatin C compared to serum creatinine as a marker of acute kidney injury in critically ill neonates. Pediatr. Nephrol. 2021; 36(1): 181-6. https://doi.org/10.1007/s00467-020-04668-3Hidayati E.L., Utami M.D., Rohsiswatmo R., Tridjaja B. Cystatin C compared to serum creatinine as a marker of acute kidney injury in critically ill neonates. Pediatr. Nephrol. 2021; 36(1): 181–6. https://doi.org/10.1007/s00467-020-04668-3Villacrés S.M., Medar S.S., Aydin S.I. Acute kidney injury in children With acute respiratory failure. Clin. Pediatr. (Phila).2018; 57(11): 1340-8. https://doi.org/10.1177/0009922818779222Villacrés S.M., Medar S.S., Aydin S.I. Acute kidney injury in children With acute respiratory failure. Clin. Pediatr. (Phila).2018; 57(11): 1340–8. https://doi.org/10.1177/0009922818779222Elmas A.T., Tabel Y., Elmas O.N. Serum cystatin C predicts acute kidney injury in preterm neonates with respiratory distress syndrome. Pediatr. Nephrol. 2013; 28(3): 477-84. https://doi.org/10.1007/s00467-012-2331-5Elmas A.T., Tabel Y., Elmas O.N. Serum cystatin C predicts acute kidney injury in preterm neonates with respiratory distress syndrome. Pediatr. Nephrol. 2013; 28(3): 477–84. https://doi.org/10.1007/s00467-012-2331-5El-Gammacy T.M., Shinkar D.M., Mohamed N.R., Al-Halag A.R. Serum cystatin C as an early predictor of acute kidney injury in preterm neonates with respiratory distress syndrome. Scand. J. Clin. Lab. Invest. 2018; 78(5): 352-7. https://doi.org/10.1080/00365513.2018.1472803El-Gammacy T.M., Shinkar D.M., Mohamed N.R., Al-Halag A.R. Serum cystatin C as an early predictor of acute kidney injury in preterm neonates with respiratory distress syndrome. Scand. J. Clin. Lab. Invest. 2018; 78(5): 352–7. https://doi.org/10.1080/00365513.2018.1472803Cho S.Y., Lee H.J., Suh J.T., Cho B.S., Suh J.S. Cystatin C/creatinine ratio in pediatric kidney disease. Clin. Exp. Nephrol. 2011; 15(6): 976-7. https://doi.org/10.1007/s10157-011-0535-9Cho S.Y., Lee H.J., Suh J.T., Cho B.S., Suh J.S. Cystatin C/creatinine ratio in pediatric kidney disease. Clin. Exp. Nephrol. 2011; 15(6): 976–7. https://doi.org/10.1007/s10157-011-0535-9Korkut S., Memur Ş., Halis H., Baştuğ O., Korkmaz L., Özdemir A., et al. A study of the relationship between cystatin C and metabolic bone disease in preterm infants. J. Clin. Res. Pediatr. Endocrinol. 2018; 10(2): 119-24. https://doi.org/10.4274/jcrpe.2088Korkut S., Memur Ş., Halis H., Baştuğ O., Korkmaz L., Özdemir A., et al. A study of the relationship between cystatin C and metabolic bone disease in preterm infants. J. Clin. Res. Pediatr. Endocrinol. 2018; 10(2): 119–24. https://doi.org/10.4274/jcrpe.2088Kjeldsen L., Johnsen A.H., Sengeløv H., Borregaard N. Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J. Biol. Chem. 1993; 268(14): 10425-32.Kjeldsen L., Johnsen A.H., Sengeløv H., Borregaard N. Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J. Biol. Chem. 1993; 268(14): 10425–32.Xu S., Venge P. Lipocalins as biochemical markers of disease. Biochim. Biophys. Acta. 2000; 1482(1-2): 298-307. https://doi.org/10.1016/s0167-4838(00)00163-1Xu S., Venge P. Lipocalins as biochemical markers of disease. Biochim. Biophys. Acta. 2000; 1482(1-2): 298–307. https://doi.org/10.1016/s0167-4838(00)00163-1Wu Y., Wang H., Pei J., Jiang X., Tang J. Acute kidney injury in premature and low birth weight neonates: a systematic review and meta-analysis. Pediatr. Nephrol. 2022; 37(2): 275-87. https://doi.org/10.1007/s00467-021-05251-0Wu Y., Wang H., Pei J., Jiang X., Tang J. Acute kidney injury in premature and low birth weight neonates: a systematic review and meta-analysis. Pediatr. Nephrol. 2022; 37(2): 275–87. https://doi.org/10.1007/s00467-021-05251-0Mishra J., Mori K., Ma Q., Kelly C., Yang J., Mitsnefes M., et al. Amelioration of ischemic acute renal injury by neutrophil gelatinase-associated lipocalin. J. Am. Soc. Nephrol. 2004; 15(12): 3073-82. https://doi.org/10.1097/01.asn.0000145013.44578.45Mishra J., Mori K., Ma Q., Kelly C., Yang J., Mitsnefes M., et al. Amelioration of ischemic acute renal injury by neutrophil gelatinase-associated lipocalin. J. Am. Soc. Nephrol. 2004; 15(12): 3073–82. https://doi.org/10.1097/01.asn.0000145013.44578.45Mori K., Lee H.T., Rapoport D., Drexler I.R., Foster K., Yang J., et al. Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury. J. Clin. Invest. 2005; 115(3): 610-21. https://doi.org/10.1172/JCI23056Mori K., Lee H.T., Rapoport D., Drexler I.R., Foster K., Yang J., et al. Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury. J. Clin. Invest. 2005; 115(3): 610–21. https://doi.org/10.1172/JCI23056Schmidt-Ott K.M., Mori K., Kalandadze A., Li J.Y., Paragas N., Nicholas T., et al. Neutrophil gelatinase-associated lipocalin-mediated iron traffic in kidney epithelia. Curr. Opin. Nephrol. Hypertens. 2006; 15(4): 442-9. https://doi.org/10.1097/01.mnh.0000232886.81142.58Schmidt-Ott K.M., Mori K., Kalandadze A., Li J.Y., Paragas N., NicholasT., et al. Neutrophil gelatinase-associated lipocalin-mediated iron traffic in kidney epithelia. Curr. Opin. Nephrol. Hypertens. 2006; 15(4): 442–9. https://doi.org/10.1097/01.mnh.0000232886.81142.58Zappitelli M., Washburn K.K., Arikan A.A., Loftis L., Ma Q., Devarajan P., et al. Urine neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in critically ill children: a prospective cohort study. Crit. Care. 2007; 11(4): R84. https://doi.org/10.1186/cc6089Zappitelli M., Washburn K.K., Arikan A.A., Loftis L., Ma Q., Devarajan P., et al. Urine neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in critically ill children: a prospective cohort study. Crit. Care. 2007; 11(4): R84. https://doi.org/10.1186/cc6089McMahon K.R., Chui H., Rassekh S.R., Schultz K.R., Blydt-Hansen T.D., Mammen C., et al. Urine neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 to detect pediatric cisplatin-associated acute kidney injury. Kidney360. 2021; 3(1): 37-50. https://doi.org/10.34067/KID.0004802021McMahon K.R., Chui H., Rassekh S.R., Schultz K.R., Blydt-Hansen T.D., Mammen C., et al. Urine neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 to detect pediatric cisplatin-associated acute kidney injury. Kidney360. 2021; 3(1): 37–50. https://doi.org/10.34067/KID.0004802021Yilmaz A., Sevketoglu E., Gedikbasi A., Karyagar S., Kiyak A., Mulazimoglu M., et al. Early prediction of urinary tract infection with urinary neutrophil gelatinase associated lipocalin. Pediatr. Nephrol. 2009; 24(12): 2387-92. https://doi.org/10.1007/s00467-009-1279-6Yilmaz A., Sevketoglu E., Gedikbasi A., Karyagar S., Kiyak A., Mulazimoglu M., et al. Early prediction of urinary tract infection with urinary neutrophil gelatinase associated lipocalin. Pediatr. Nephrol. 2009; 24(12): 2387–92. https://doi.org/10.1007/s00467-009-1279-6Krzemień G., Pańczyk-Tomaszewska M., Kotuła I., Demkow U., Szmigielska A. Serum neutrophil gelatinase-associated lipocalin for predicting acute pyelonephritis in infants with urinary tract infection. Cent. Eur. J. Immunol. 2019; 44(1): 45-50. https://doi.org/10.5114/ceji.2019.84016Krzemień G., Pańczyk-Tomaszewska M., Kotuła I., Demkow U., Szmigielska A. Serum neutrophil gelatinase-associated lipocalin for predicting acute pyelonephritis in infants with urinary tract infection. Cent. Eur. J. Immunol. 2019; 44(1): 45–50. https://doi.org/10.5114/ceji.2019.84016Parravicini E., Nemerofsky S.L., Michelson K.A., Huynh T.K., Sise M.E., Bateman D.A., et al. Urinary neutrophil gelatinase-associated lipocalin is a promising biomarker for late onset culture-positive sepsis in very low birth weight infants. Pediatr. Res. 2010; 67(6): 636-40. https://doi.org/10.1203/PDR.0b013e3181da75c1Parravicini E., Nemerofsky S.L., Michelson K.A., Huynh T.K., Sise M.E., Bateman D.A., et al. Urinary neutrophil gelatinase-associated lipocalin is a promising biomarker for late onset culture-positive sepsis in very low birth weight infants. Pediatr. Res. 2010; 67(6): 636–40. https://doi.org/10.1203/PDR.0b013e3181da75c1Nickolas T.L., O’Rourke M.J., Yang J., Sise M.E., Canetta P.A., Barasch N., et al. Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury. Ann.Intern. Med. 2008; 148(11): 810-9. https://doi.org/10.7326/0003-4819-148-11-200806030-00003Nickolas T.L., O’Rourke M.J., Yang J., Sise M.E., Canetta P.A., Barasch N., et al. Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury. Ann. Intern. Med. 2008; 148(11): 810–9. https://doi.org/10.7326/0003-4819-148-11-200806030-00003Parravicini E., Lorenz J.M., Nemerofsky S.L., O’Rourke M., Barasch J., Bateman D. Reference range of urinary neutrophil gelatinase-associated lipocalin in very low-birth-weight infants: preliminary data. Am. J. Perinatol. 2009; 26(6): 437-40. https://doi.org/10.1055/s-0029-1214242Parravicini E., Lorenz J.M., Nemerofsky S.L., O’Rourke M., Barasch J., Bateman D. Reference range of urinary neutrophil gelatinase-associated lipocalin in very low-birth-weight infants: preliminary data. Am. J. Perinatol. 2009; 26(6): 437–40. https://doi.org/10.1055/s-0029-1214242Huynh T.K., Bateman D.A., Parravicini E., Lorenz J.M., Nemerofsky S.L., Sise M.E., et al. Reference values of urinary neutrophil gelatinase-associated lipocalin in very low birth weight infants. Pediatr. Res. 2009; 66(5): 528-32. https://doi.org/10.1203/PDR.0b013e3181baa3ddHuynh T.K., Bateman D.A., Parravicini E., Lorenz J.M., Nemerofsky S.L., Sise M.E., et al. Reference values of urinary neutrophil gelatinase-associated lipocalin in very low birth weight infants. Pediatr. Res. 2009; 66(5): 528–32. https://doi.org/10.1203/PDR.0b013e3181baa3ddRonco C., Legrand M., Goldstein S.L., Hur M., Tran N., Howell E.C., et al. Neutrophil gelatinase-associated lipocalin: ready for routine clinical use? An international perspective. Blood Purif. 2014; 37(4): 271-85. https://doi.org/10.1159/000360689Ronco C., Legrand M., Goldstein S.L., Hur M., Tran N., Howell E.C., et al. Neutrophil gelatinase-associated lipocalin: ready for routine clinical use? An international perspective. Blood Purif. 2014; 37(4): 271–85. https://doi.org/10.1159/000360689Lavery A.P., Meinzen-Derr J.K., Anderson E., Ma Q., Bennett M.R., Devarajan P., et al. Urinary NGAL in premature infants Pediatr. Res. 2008; 64(4): 423-8. https://doi.org/10.1203/PDR.0b013e318181b3b2Lavery A.P., Meinzen-Derr J.K., Anderson E., Ma Q., Bennett M.R., Devarajan P., et al. Urinary NGAL in premature infants Pediatr. Res. 2008; 64(4): 423–8. https://doi.org/10.1203/PDR.0b013e318181b3b2Filho L.T., Grande A.J., Colonetti T., Della E.S.P., da Rosa M.I. Accuracy of neutrophil gelatinase-associated lipocalin for acute kidney injury diagnosis in children: systematic review and meta-analysis. Pediatr. Nephrol. 2017; 32(10): 1979-88. https://doi.org/10.1007/s00467-017-3704-6Filho L.T., Grande A.J., Colonetti T., Della E.S.P., da Rosa M.I. Accuracy of neutrophil gelatinase-associated lipocalin for acute kidney injury diagnosis in children: systematic review and meta-analysis. Pediatr. Nephrol. 2017; 32(10): 1979–88. https://doi.org/10.1007/s00467-017-3704-6Capelli I., Vitali F., Zappulo F., Martini S., Donadei C., Cappuccilli M., et al. Biomarkers of kidney injury in very-low-birth-weight preterm infants: influence of maternal and neonatal factors. In Vivo. 2020; 34(3): 1333-9. https://doi.org/10.21873/invivo.11910Capelli I., Vitali F., Zappulo F., Martini S., Donadei C., Cappuccilli M., et al. Biomarkers of kidney injury in very-low-birth-weight preterm infants: influence of maternal and neonatal factors. In Vivo. 2020; 34(3): 1333–9. https://doi.org/10.21873/invivo.11910Suchojad A., Tarko A., Smertka M., Majcherczyk M., Brzozowska A., Wroblewska J., et al. Factors limiting usefulness of serum and urinary NGAL as a marker of acute kidney injury in preterm newborns. Ren. Fail. 2015; 37(3): 439-45. https://doi.org/10.3109/0886022X.2014.996109Suchojad A., Tarko A., Smertka M., Majcherczyk M., Brzozowska A., Wroblewska J., et al. Factors limiting usefulness of serum and urinary NGAL as a marker of acute kidney injury in preterm newborns. Ren. Fail. 2015; 37(3): 439–45. https://doi.org/10.3109/0886022X.2014.996109Yuan S.M. Acute kidney injury after pediatric cardiac surgery. Pediatr. Neonatol. 2019; 60(1): 3-11. https://doi.org/10.1016/j.pedneo.2018.03.007Yuan S.M. Acute kidney injury after pediatric cardiac surgery. Pediatr. Neonatol. 2019; 60(1): 3–11. https://doi.org/10.1016/j.pedneo.2018.03.007Mishra J., Dent C., Tarabishi R., Mitsnefes M.M., Ma Q., Kelly C., et al. Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet. 2005; 365(9466): 1231-8. https://doi.org/10.1016/S0140-6736(05)74811-XMishra J., Dent C., Tarabishi R., Mitsnefes M.M., Ma Q., Kelly C., et al. Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet. 2005; 365(9466): 1231–8. https://doi.org/10.1016/S0140-6736(05)74811-XSeitz S., Rauh M., Gloeckler M., Cesnjevar R., Dittrich S., Koch A.M. Cystatin C and neutrophil gelatinase-associated lipocalin: biomarkers for acute kidney injury after congenital heart surgery. Swiss. Med. Wkly. 2013; 143: w13744. https://doi.org/10.4414/smw.2013.13744Seitz S., Rauh M., Gloeckler M., Cesnjevar R., Dittrich S., Koch A.M. Cystatin C and neutrophil gelatinase-associated lipocalin: biomarkers for acute kidney injury after congenital heart surgery. Swiss. Med. Wkly. 2013; 143: w13744. https://doi.org/10.4414/smw.2013.13744Herbert C. Patel M., Nugent A., Dimas V.V., Guleserian K.J., Quigley R., et al. Serum cystatin C as an early marker of neutrophil gelatinase-associated lipocalin-positive acute kidney injury resulting from cardiopulmonary bypass in infants with congenital heart disease. Congenit. Heart Dis. 2015; 10(4): 180-8. https://doi.org/10.1111/chd.12253Herbert C. Patel M., Nugent A., Dimas V.V., Guleserian K.J., Quigley R., et al. Serum cystatin C as an early marker of neutrophil gelatinase-associated lipocalin-positive acute kidney injury resulting from cardiopulmonary bypass in infants with congenital heart disease. Congenit. Heart Dis. 2015; 10(4): 180–8. https://doi.org/10.1111/chd.12253Sellmer A., Bech B.H., Bjerre J.V., Schmidt M.R., Hjortdal V.E., Esberg G., et al. Urinary neutrophil gelatinase-associated lipocalin in the evaluation of patent ductus arteriosus and AKI in very preterm neonates: a cohort study. BMC Pediatr. 2017; 17(1): 7. https://doi.org/10.1186/s12887-016-0761-0Sellmer A., Bech B.H., Bjerre J.V., Schmidt M.R., Hjortdal V.E., Esberg G., et al. Urinary neutrophil gelatinase-associated lipocalin in the evaluation of patent ductus arteriosus and AKI in very preterm neonates: a cohort study. BMC Pediatr. 2017; 17(1): 7. https://doi.org/10.1186/s12887-016-0761-0Inoue H., Ohga S., Kusuda T., Kitajima J., Kinjo T., Ochiai M., et al. Serum neutrophil gelatinase-associated lipocalin as a predictor of the development of bronchopulmonary dysplasia in preterm infants. Early Hum. Dev. 2013; 89(6): 425-9. https://doi.org/10.1016/j.earlhumdev.2012.12.011Inoue H., Ohga S., Kusuda T., Kitajima J., Kinjo T., Ochiai M., et al. Serum neutrophil gelatinase-associated lipocalin as a predictor of the development of bronchopulmonary dysplasia in preterm infants. Early Hum. Dev. 2013; 89(6): 425–9. https://doi.org/10.1016/j.earlhumdev.2012.12.011Sutherland S.M., Zappitelli M., Alexander S.R., Chua A.N., Brophy P.D., Bunchman T.E., et al. Fluid overload and mortality in children receiving continuous renal replacement therapy: the prospective pediatric continuous renal replacement therapy registry. Am. J. Kidney. Dis. 2010; 55(2): 316-25. https://doi.org/10.1053/j.ajkd.2009.10.048Sutherland S.M., Zappitelli M., Alexander S.R., Chua A.N., Brophy P.D., Bunchman T.E., et al. Fluid overload and mortality in children receiving continuous renal replacement therapy: the prospective pediatric continuous renal replacement therapy registry. Am. J. Kidney. Dis. 2010; 55(2): 316–25. https://doi.org/10.1053/j.ajkd.2009.10.048Roy J.P., Krallman K.A., Basu R.K., Chima R.S., Fei L., Wilder S., et al. Early sequential risk stratification assessment to optimize fluid dosing, CRRT initiation and discontinuation in critically ill children with acute kidney injury: taking focus 2 process article. J. Clin. Trials. 2020; 10(6): 435.Roy J.P., Krallman K.A., Basu R.K., Chima R.S., Fei L., Wilder S., et al. Early sequential risk stratification assessment to optimize fluid dosing, CRRT initiation and discontinuation in critically ill children with acute kidney injury: taking focus 2 process article. J. Clin. Trials. 2020; 10(6): 435.Elmas A.T., Tabel Y., Ipek S. Determination of reference values for urinary neutrophil gelatinase-associated lipocalin in premature infants. J. Matern. Fetal. Neonatal. Med. 2014; 27(2): 187-91. https://doi.org/10.3109/14767058.2013.806900Elmas A.T., Tabel Y., Ipek S. Determination of reference values for urinary neutrophil gelatinase-associated lipocalin in premature infants. J. Matern. Fetal. Neonatal. Med. 2014; 27(2): 187–91. https://doi.org/10.3109/14767058.2013.806900Waikar S.S., Liu K.D., Chertow G.M. Diagnosis, epidemiology and outcomes of acute kidney injury. Clin. J. Am. Soc. Nephrol. 2008; 3(3): 844-61. https://doi.org/10.2215/cjn.05191107Waikar S.S., Liu K.D., Chertow G.M. Diagnosis, epidemiology and outcomes of acute kidney injury. Clin. J. Am. Soc. Nephrol. 2008; 3(3): 844–61. https://doi.org/10.2215/cjn.05191107

The authors declare that there are no conflicts of interest present.