rospedРоссийский педиатрический журнал имени М.Я. СтуденикинаM.Ya. Studenikin Russian Pediatric JournalФГАУ «НМИЦ здоровья детей» Минздрава России10.46563/1560-9561-2022-25-2-84-90xgyfhmrosped-335Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL INVESTIGATIONSДинамика индикаторов эндотелиальной дисфункции при ожирении у детейDynamics of indicators of endothelial dysfunction in children with obesityhttps://orcid.org/0000-0002-4679-0533СмирновИван ЕвгеньевичSmirnovIvan Evgenievich

Доктор мед. наук, проф., нач. методического отдела ФГАУ «НМИЦ здоровья детей» Минздрава России.

e-mail: smirnov@nczd.ru

Doctor of Medical Sciences, Professor, Head, Methodical department of the NMRC for Children’s Health of the Ministry of Health of Russia.

e-mail: smirnov@nczd.ru

smirnov@nczd.ruhttps://orcid.org/0000-0001-8586-7946ФисенкоАндрей ПетровичFisenkoAndrey P.

Доктор мед. наук, проф., директор ФГАУ «НМИЦ здоровья детей» Минздрава России; проф. каф. многопрофильной клинической подготовки факультета фундаментальной медицины ФГБОУ ВО «МГУ им. М.В. Ломоносова».

e-mail: director@nczd.ru

director@nczd.ruhttps://orcid.org/0000-0001-6287-8204КучеренкоАлла ГеоргиевнаKucherenkoAlla G.

Доктор мед. наук, проф. гл. специалист ФГАУ «НМИЦ здоровья детей» Минздрава России.

e-mail: kucherenko@nczd.ru

kucherenko@nczd.ruhttps://orcid.org/0000-0002-8165-6567СмирноваГалина ИвановнаSmirnovaGalina I.

Доктор мед. наук, проф., каф. педиатрии и детских инфекционных болезней ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» Минздрава России (Сеченовский Университет).

e-mail: gismirnova@yandex.ru

gismirnova@yandex.ruПостниковаЕкатерина ВладимировнаPostnikovaEkaterina V.

Аспирант ФГАУ «НМИЦ здоровья детей» Минздрава России.

noemail@neicon.ruФГАУ «Национальный медицинский исследовательский центр здоровья детей» Минздрава РоссииРоссияNational Medical Research Center for Children’s HealthRussian FederationФГАУ «Национальный медицинский исследовательский центр здоровья детей» Минздрава России; ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»РоссияNational Medical Research Center for Children’s Health; M.V. Lomonosov Moscow State UniversityRussian FederationФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» (Сеченовский университет) Минздрава РоссииРоссияI.M. Sechenov Moscow State Medical University (Sechenov University)Russian Federation2022290920232528490Copyright © Смирнов И.Е., Фисенко А.П., Кучеренко А.Г., Смирнова Г.И., Постникова Е.В., 20232023Смирнов И.Е., Фисенко А.П., Кучеренко А.Г., Смирнова Г.И., Постникова Е.В.Smirnov I.E., Fisenko A.P., Kucherenko A.G., Smirnova G.I., Postnikova E.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rosped.ru/jour/article/view/335Введение

Введение. Конституционально-экзогенное ожирение (КЭО) относится к ряду значимых медико-социальных проблем современного мира, принимает масштабы эпидемии и лидирует среди алиментарно-зависимой патологии у детей.

Цель работы — изучение изменений индикаторов эндотелиальной дисфункции при различной выраженности ожирения у детей.

Материалы и методы

Материалы и методы. Комплексно обследованы 126 детей в возрасте 6–17 лет, из них 110 пациентов с различной выраженностью КЭО. В сыворотке крови определяли содержание медиаторов эндотелиальной дисфункции: оксида азота, эндотелина-1, лептина, гомоцистеина, молекул межклеточной адгезии и  адгезии сосудистых клеток-1, антигена ингибитора активатора плазминогена тканевого типа, фактора Виллебранда и его антигена.

Результаты

Результаты. Установлены закономерности изменений концентраций указанных соединений в крови в зависимости от возраста больных и степени ожирения, отражающие нарушения функционального состояния эндотелиальной системы. 

Заключение

Заключение. Индикаторы эндотелиальной дисфункции могут служить критериями её выраженности, их выявление позволит оптимизировать раннюю диагностику и определить объём своевременной терапии.

Участие авторов

Участие авторов:Смирнов И.Е., Кучеренко А.Г. — концепция и дизайн исследования;Кучеренко А.Г., Постникова Е.В., Смирнова Г.И. — cбор материала;Кучеренко А.Г., Смирнов И.Е. — cтатистическая обработка;Смирнов И.Е. — написание текста;Фисенко А.П. — редактирование.Все соавторы — утверждение окончательного варианта статьи, ответственность за целостность всех частей статьи.

Финансирование

Финансирование. Исследование не имело финансовой поддержки.

Конфликт интересов

Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов. 

Поступила 25

Поступила 25.04.2022Принята к печати 26.04.2022Опубликована 07.05.2022

Introduction

Introduction. Constitutionally exogenous obesity (CEO) belongs to a number of significant medical and social problems of the modern world, assumes epidemic proportions and leads among alimentary-dependent pathology in children.

The aim of the work was to determine changes in indicators of endothelial dysfunction (ED) in children of different age with obesity of various severity.

Materials and methods

Materials and methods. One hundred twenty six children aged of 6 to 17 years were comprehensively examined, data on changes in the serum content of ED mediators in CEOs grade 1–3 were presented by quantitative determination of nitric oxide, endothelin-1, leptin, homocysteine, intercellular adhesion molecules and vascular cell adhesion-1, tissue-type plasminogen activator inhibitor antigen, Willebrand factor and his antigen.

Results

Results. The regularities of changes in the concentrations of these compounds in the blood depending on the age of patients and the degree of obesity, which reflect the functional state of the endothelial system and can serve as criteria for the severity of ED requiring adequate and timely correction in children, have been established.

Conclusion

Conclusion. Indicators of endothelial dysfunction can serve as criteria for its severity, their detection will allow optimizing early diagnosis and determining the amount of timely therapy.

Contribution

Contribution:Smirnov I.E., Kucherenko A.G. — concept and design of the study;Kucherenko A.G., Postnikova E.V., Smirnova G.I. — collection of material;Kucherenko A.G., Smirnov I.E. — statistical processing;Smirnov I.E. — writing of the text;Fisenko A.P. — editing.All co-authors — approval of the final version of the article, responsibility for the integrity of all parts of the article.

Acknowledgment

Acknowledgment. The study had no sponsorship.

Conflict of interest

Conflict of interest. The authors declare no conflict of interest.

Received

Received: April 25, 2022Accepted: April 26, 2022Published: May 07, 2022

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The authors declare that there are no conflicts of interest present.