rospedРоссийский педиатрический журнал имени М.Я. СтуденикинаM.Ya. Studenikin Russian Pediatric JournalФГАУ «НМИЦ здоровья детей» Минздрава России10.46563/1560-9561-2022-25-2-121-127lfhkxorosped-340Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL INVESTIGATIONSЦистатин C как индикатор функционального состояния почек у детей раннего возрастаCystatin C as an indicator of the functional state of the kidneys in young childrenhttps://orcid.org/0000-0002-8021-9592ЦинцадзеБелла ДжемалиевнаTsintsadzeBella D.

Аспирант отделения патологии раннего детского возраста ФГАУ «НМИЦ здоровья детей» Минздрава России.

e-mail: tsintsadze@nczd.ru

Postgraduate student of the Department of Early Childhood Pathology, National Medical Research Center for Children’s Health, Moscow, 119991, Russian Federation.

e-mail: tsintsadze@nczd.ru

tsintsadze@nczd.ruhttps://orcid.org/0000-0003-4657-7879КазаковаКлавдия АлександровнаKazakovaKlavdiia A.

Канд. мед. наук, зав. отд-нием патологии раннего детского возраста.

e-mail: kazakova.ka@nczd.ru

kazakova.ka@nczd.ruhttps://orcid.org/0000-0002-8750-9285ЧерниковВладислав ВладимировичChernikovVladislav V.

Канд. мед. наук, начальник методического аккредитационно-симуляционного центра.

e-mail: chernikov@nczd.ru

chernikov@nczd.ruhttps://orcid.org/0000-0001-8586-7946ФисенкоАндрей ПетровичFisenkoAndrey P.

Доктор мед. наук, проф., директор ФГАУ «НМИЦ здоровья детей» Минздрава России.

e-mail: director@nczd.ru

director@nczd.ruhttps://orcid.org/0000-0002-6292-7229ЖужулаАнастасия АндреевнаZhuzhulaAnastasiya A.

Мл. науч. сотр. лаб. экспериментальной иммунологии и вирусологии.

e-mail: zhuzhula.aa@nczd.ru

zhuzhula.aa@nczd.ruhttps://orcid.org/0000-0001-9365-9143АлябьеваНаталья МихайловнаAlyabievaNatalia M.

Канд. мед. наук, зав. лаб. экспериментальной иммунологии и вирусологии.

e-mail: aliabeva.nm@nczd.ru

aliabeva.nm@nczd.ruhttps://orcid.org/0000-0001-6301-9313ЦыгинАлексей НиколаевичTsyginAleksey N.

Доктор мед. наук, проф., зав. нефрологическим отделением.

e-mail: tsygin@nczd.ru

tsygin@nczd.ruФГАУ «Национальный медицинский исследовательский центр здоровья детей» Минздрава РоссииNational Medical Research Center for Children’s Health202229092023252121127Copyright © Цинцадзе Б.Д., Казакова К.А., Черников В.В., Фисенко А.П., Жужула А.А., Алябьева Н.М., Цыгин А.Н., 20232023Цинцадзе Б.Д., Казакова К.А., Черников В.В., Фисенко А.П., Жужула А.А., Алябьева Н.М., Цыгин А.Н.Tsintsadze B.D., Kazakova K.A., Chernikov V.V., Fisenko A.P., Zhuzhula A.A., Alyabieva N.M., Tsygin A.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rosped.ru/jour/article/view/340Введение

Введение. Достоверных сведений об изменениях концентраций цистатина С (ЦС) в крови и определения скорости клубочковой фильтрации (СКФ) на их основе у детей раннего возраста недостаточно.

Цель

Цель: определить содержание ЦС в крови и СКФ на его основе у детей раннего возраста.

Материалы и методы

Материалы и методы. Комплексно обследовано 237 детей без патологии почек в возрасте от рождения до 3 лет, дети распределены на подгруппы по возрасту, по степени доношенности и массе тела при рождении. Сывороточную концентрацию ЦС определяли иммуноферментным анализом, СКФ была рассчитана по формуле Ларссона.

Результаты

Результаты. У детей раннего возраста определены нормальные значения сывороточного ЦС и уровни СКФ, рассчитанной по формуле Ларссона на основе ЦС. Установлена зависимость сывороточного уровня ЦС и СКФ, рассчитанной на его основе, от возраста детей. Показано, что содержание сывороточного ЦС зависит от степени недоношенности и массы тела при рождении. На уровень СКФ не влияла степень недоношенности. Однако у новорождённых с экстремально низкой массой тела СКФ была снижена по сравнению со СКФ у рождённых с нормальной массой тела.

Заключение

Заключение. Полученные показатели сывороточного ЦС предлагаются в качестве нормальных для детей раннего возраста, доношенных и с разной степенью недоношенности.

Участие авторов

Участие авторов: Цинцадзе Б.Д., Казакова К.А. — концепция и дизайн исследования;Цинцадзе Б.Д., Жужула А.А., Алябьева Н.М. — сбор и обработка материала;Черников В.В. — статистическая обработка;Цинцадзе Б.Д., Казакова К.А. — написание текста;Фисенко А.П., Цыгин А.Н. — редактирование.Все соавторы — утверждение окончательного варианта статьи, ответственность за целостность всех её частей.

Финансирование

Финансирование. Исследование не имело финансовой поддержки.

Конфликт интересов

Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов. 

Поступила 25

Поступила 25.04.2022Принята к печати 26.04.2022Опубликована 07.05.2022

Introduction

Introduction. Currently widely adopted benchmarks of normal levels of cystatin in blood and of GFR based on those levels in young children are non-existent.

Objective

Objective: to determine the content of cystatin C in the blood and the glomerular filtration rate based on it in young children. 

Materials and methods

Materials and methods. Two hundred thirty seven infants aged up 3 years without kidney diseases were examined and divided into subgroups by age, degree of maturity and birth weight. The serum cystatin C was studied by enzyme-immunoassay, GFR was calculated according to Larsson’s formula.

Results

Results. Normal levels of serum cystatin C and GFR levels were determined in young children with Larsson’s formula. The dependency of the serum level of cystatin C and GFR calculated on the basis of the age of the infant was proved. The serum cystatin C level depends on the degree of prematurity and body weight at birth. The level of GFR was not influenced by the degree of prematurity, however, infants born with extremely low body weight exhibited lower GFR levels in comparison to those born with normal body weight.

Conclusion

Conclusion. The obtained serum cystatin C levels are deemed as normal for young children — full-term infants and those with varying degrees of prematurity.

Contribution

Contribution:Tsintsadze B.D., Kazakova K.A. — research concept and design of the study;Tsintsadze B.D., Kazakova K.A., Zhuzhula A.A., Alyabieva N.M. — collection and processing of material;Chernikov V.V. — statistical processing;Tsintsadze B.D., Kazakova K.A. — text writing;Fisenko A.P., Tsygin A.N. — editing.All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version. 

Acknowledgment

Acknowledgment. The study had no sponsorship.

Conflict of interest

Conflict of interest. The authors declare no conflict of interest.

Received

Received: April 25, 2022Accepted: April 26, 2022Published: May 07, 2022

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The authors declare that there are no conflicts of interest present.