rospedРоссийский педиатрический журнал имени М.Я. СтуденикинаM.Ya. Studenikin Russian Pediatric JournalФГАУ «НМИЦ здоровья детей» Минздрава России10.46563/1560-9561-2022-25-1-28-31fyihcfrosped-347Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL INVESTIGATIONSМатематическое моделирование в изучении патогенеза вирусного гепатита у детейMathematical modelling in the study of the pathogenesis of viral hepatitis in childrenhttps://orcid.org/0000-0002-0818-5316МартусевичАндрей КимовичMartusevichAndrey K.

Доктор биол. наук, вед. науч. сотр., руководитель лаб., медицинской биофизики Университетской клиники ФГБОУ ВО ПИМУ Минздрава России.

e-mail: cryst-mart@yandex.ru

cryst-mart@yandex.ruhttps://orcid.org/0000-0002-9574-2933ГаловаЕлена АнатольевнаGalovaElena A.

Канд. мед. наук, зам. директора Университетской клиники по науке, ФГБОУ ВО ПИМУ Минздрава России.

e-mail: galova75@mail.ru

galova75@mail.ruhttps://orcid.org/0000-0002-3717-2186ПоповичеваАлександра НиколаевнаPopovichevaAleksandra N.

Мл. науч. сотр. лаб. медицинской биофизики Университетской клиники ФГБОУ ВО ПИМУ Минздрава России.

e-mail: alexandra.popovichus@yandex.ru

Junior researcher, Laboratory of medical biophysics of the University Clinic, Privolzhsky Research Medical University, Nizhny Novgorod, 603950, Russian Federation.

e-mail: alexandra.popovichus@yandex.ru

alexandra.popovichus@yandex.ruФГБОУ ВО «Приволжский исследовательский медицинский университет» Минздрава РоссииРоссияPrivolzhsky Research Medical UniversityRussian Federation2022111020232512831Copyright © Мартусевич А.К., Галова Е.А., Поповичева А.Н., 20232023Мартусевич А.К., Галова Е.А., Поповичева А.Н.Martusevich A.K., Galova E.A., Popovicheva A.N.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rosped.ru/jour/article/view/347

Цель работы — сформировать математическую модель вирусных гепатитов на основании структурного моделирования, дискриминантного и факторного анализов лабораторных параметров пациентов.

Материалы и методы

Материалы и методы. В массив данных были включены данные комплексного лабораторного обследования 109 детей с вирусными гепатитами В и С (33 параметра).

Результаты

Результаты. Выявлены 7 основных факторов патогенеза вирусного гепатита у детей, преимущественно отражающих выраженность эндогенной интоксикации и нарушений белкового обмена, а также определена модификация режима функционирования ферментов и надмолекулярных мультиэнзимных комплексов в условиях прогрессирования первых двух компонентов.

Заключение

Заключение. Выделенные факторы патогенеза вирусного гепатита у детей способны отражать развивающуюся в процессе формирования патологии эндогенную интоксикацию, состояние ферментных систем детоксикации и формирующиеся в дальнейшем фибротические изменения в печени.

Участие авторов

Участие авторов:Мартусевич А.К., Галова Е.А., Поповичева А.Н. — концепция и дизайн исследования, сбор и обработка материала, написание текста.Все соавторы — утверждение окончательного варианта статьи, ответственность за целостность всех её частей.

Финансирование

Финансирование: авторы статьи подтверждают отсутствие финансовой поддержки.

Конфликт интересов

Конфликт интересов: авторы заявили об отсутствии конфликта интересов.

Поступила 14

Поступила 14.01.2022Принята к печати 17.02.2022Опубликована 15.03.2022

The aim of the work is to form a mathematical model of viral hepatitis based on structural modelling, discriminant and factorial analysis of laboratory parameters of patients.

Materials and methods

Materials and methods. The data array included the results of a comprehensive laboratory testing of 109 children with viral hepatitis B and C (33 parameters).

Results

Results. Seven main factors in the pathogenesis of viral hepatitis in children reflect the severity of endogenous intoxication and disorders of protein metabolism, modification of the mode of functioning of enzymes, and supramolecular multi-enzyme complexes in conditions of progression of the first two components.

Conclusion

Conclusion. The identified factors of the pathogenesis of viral hepatitis may reflect the endogenous intoxication during disease progression, the state of detoxification enzyme systems, and the further fibrotic changes in the liver.

Contribution

Contribution:Martusevich A.K. — the concept and design of the study, the collection and processing of material, writing the text;Galova E.A. — providing material for research;Korkotashvili L.V. — carrying out mathematical modeling;Popovicheva A.N. — editing the text of the article.Аll co-authors — аpproval of the final version of the article, responsibility for the integrity of all parts of the article.

Informed consent

Informed consent: informed consent was received from the patients parents for the publication of a description of the clinical case.

Acknowledgment

Acknowledgment. The study had no sponsorship.

Conflict of interest

Conflict of interest. The authors declare no conflict of interest.

Received

Received: January 14, 2022Accepted: February 17, 2022Published: March 15, 2022

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The authors declare that there are no conflicts of interest present.