rospedРоссийский педиатрический журнал имени М.Я. СтуденикинаM.Ya. Studenikin Russian Pediatric JournalФГАУ «НМИЦ здоровья детей» Минздрава России10.46563/1560-9561-2023-26-5-368-375avtemarosped-369Research ArticleОБЗОРЫREVIEWSПищевая аллергия к белкам коровьего молока и мясуFood allergy to cow’s milk proteins and meathttps://orcid.org/0000-0002-1149-7927РевякинаВера АфанасьевнаRevyakinaVera A.

Доктор мед. наук, проф., зав. отд-нием аллергологии и диетотерапии ФГБУН «ФИЦ питания и биотехнологии».e-mail: 5356797@mail.ru

MD, PhD, DSci., Prof., Head of the Department of allergology and diet therapy, Federal Research Center for Nutrition and Biotechnology, and Food Safety, Moscow, 115446, Russian Federation.

e-mail: 5356797@mail.ru

5356797@mail.ruhttps://orcid.org/0000-0001-8549-9493МухортыхВалерий АлексеевичMukhortykhValeriy A.

Канд. мед. наук, мл. науч. сотр. отд-ния аллергологии и диетотерапии ФГБУН «ФИЦ питания и биотехнологии», врач-педиатр, ФГБУ «ФНКЦ детей и подростков» ФМБА.

e-mail: valera-89@yandex.ru

valera-89@yandex.ruhttps://orcid.org/0000-0001-7640-0754ЛарьковаИнна АнатольевнаLarkovaInna A.

Канд. мед. наук, ст. науч. сотр. отд-ния аллергологии и диетотерапии ФГБУН «ФИЦ питания и биотехнологии».

e-mail: inna_larkova@mail.ru

inna_larkova@mail.ruhttps://orcid.org/0000-0003-3650-6305КувшиноваЕлена ДмитриевнаKuvshinovaElena D.

Канд. мед. наук, ст. науч. сотр. отделения аллергологии и диетотерапии ФГБУН «ФИЦ питания и биотехнологии.

e-mail: len.kuwshinowa@yandex.ru

len.kuwshinowa@yandex.ruФГБУ «Федеральный исследовательский центр питания, биотехнологии и безопасности пищи»; ФГАУ «Национальный медицинский исследовательский центр здоровья детей» Минздрава РоссииFederal Research Center for Nutrition, Biotechnology, and Food Safety; National Medical Research Center for Children’s HealthФГБУ «Федеральный исследовательский центр питания, биотехнологии и безопасности пищи»; ФГБУ «Федеральный научно-клинический центр детей и подростков ФМБА России»Federal Research Center for Nutrition, Biotechnology, and Food Safety; Federal Scientific and Clinical Center for Children and AdolescentsФГБУ «Федеральный исследовательский центр питания, биотехнологии и безопасности пищи»Federal Research Center for Nutrition, Biotechnology, and Food Safety202317112023265368375Copyright © Ревякина В.А., Мухортых В.А., Ларькова И.А., Кувшинова Е.Д., 20232023Ревякина В.А., Мухортых В.А., Ларькова И.А., Кувшинова Е.Д.Revyakina V.A., Mukhortykh V.A., Larkova I.A., Kuvshinova E.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rosped.ru/jour/article/view/369

Коровье молоко и мясные продукты являются важными источниками животных белков, кальция, витаминов и минералов. Они широко используются в питании детей и способствуют их нормальному развитию и устойчивости к действию неблагоприятных внешних факторов. При этом коровье молоко может вызывать у детей серьёзные аллергические реакции, вплоть до анафилаксии. В большинстве случаев к 5 годам жизни у детей формируется толерантность к белкам коровьего молока. Однако у части детей школьного возраста может сохраняться к ним повышенная чувствительность. В таких случаях ценную информацию о повышенной чувствительности к белку коровьего молока и его компонентам даёт молекулярная диагностика, позволяющая идентифицировать значимые компоненты (α-лактоальбумин, β-лактоглобулин, бычий сывороточный альбумин) молочного белка для назначения рациональной диетотерапии с учётом перекрёстных реакций с мясом говядины. В обзоре систематизированы данные об аллергии к белкам коровьего молока и его компонентам, а также к мясу говядины. Определение особенностей аллергии к белкам коровьего молока и его компонентам, дающих перекрёстные реакции с говядиной, позволит избежать серьёзных последствий нерациональных элиминационных диет.

Участие авторов

Участие авторов:Ревякина В.А. — концепция и дизайн исследования, написание текста;Ларькова И.А., Мухортых В.А., Кувшинова Е.Д. — сбор и обработка материала;Мухортых В.А., Ларькова И.А. — редактирование.Все соавторы — утверждение окончательного варианта статьи, ответственность за целостность всех частей статьи.

Финансирование

Финансирование. Исследование не имело финансовой поддержки.

Конфликт интересов

Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов.

Поступила 10

Поступила 10.08.2023Принята к печати 12.09.2023Опубликована 31.10.2023

Introduction

Introduction. Cow’s milk and dairy products are important sources of high-quality animal proteins, calcium, vitamins, and minerals. They are widely used in the diet of preschool and school-age children and contribute to the normal development and resilience of children against the effects of adverse external factors. However, cow’s milk can cause serious allergic reactions in children, even leading to anaphylaxis. Allergy to cow’s milk proteins is one of the common allergic reactions among preschool-age children. Through conducted research, patterns of the natural course of milk allergy over time have been established. In most cases, by the age of 5 years, children develop tolerance to cow’s milk proteins. However, some school-age children may retain heightened sensitivity to them. Sustaining such prolonged milk allergy in a school-age child requires identifying the cause and conducting in-depth examinations for each specific patient. In such cases, valuable information about elevated sensitivity to whole cow’s milk protein and its components is provided by molecular (component-based) diagnostics. This enables the identification of causally significant components (α-lactalbumin, β-lactoglobulin, bovine serum albumin) of milk protein for the purpose of rational diet therapy, considering cross-reactions with beef meat. The presented article summarizes and systematizes literary and proprietary data on allergy to cow’s milk proteins and its components, as well as to beef meat. Understanding the characteristics of allergy to cow’s milk proteins and its components, cross-reacting with beef, will help avoid serious consequences of irrational elimination diets.

Contribution

Contribution:Revyakina V.A. — research concept and design of the study, writing the text;Larkova I.A., Mukhortykh V.A., Kuvshinova E.D. — collection and processing of material;Mukhortykh V.A., Larkova I.A. — editing the text.All co-­authors — approval of the final version of the article, responsibility for the integrity of all parts of the article.

Acknowledgment

Acknowledgment. The study had no sponsorship.

Conflict of interest

Conflict of interest. The authors declare no conflict of interest.

Received

Received: August 10, 2023Accepted: September 12, 2023Published: October 31, 2023

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The authors declare that there are no conflicts of interest present.