rospedРоссийский педиатрический журнал имени М.Я. СтуденикинаM.Ya. Studenikin Russian Pediatric JournalФГАУ «НМИЦ здоровья детей» Минздрава России10.46563/1560-9561-2021-24-6-389-394itnnkyrosped-393Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL INVESTIGATIONSВлияние гипербарической оксигенации на состояние клеток крови у детей с воспалительными заболеваниями кишечникаThe effect of hyperbaric oxygenation on the state of blood cells in children with inflammatory bowel diseasesПоповичеваАлександра НиколаевнаPopovichevaAlexandra Nikolaevna

Мл. науч. сотр. лаб. медицинской биофизики Университетской клиники ФГБОУ ВО ПИМУ Минздрава России

e-mail: alexandra.popovichus@yandex.ru

Junior researcher at the Laboratory of medical biophysics of the University Clinic of the Privolzhsky Research Medical University

alexandra.popovichus@yandex.ru

alexandra.popovichus@yandex.ruМартусевичАндрей КимовичMartusevichAndrey K.

Доктор биол. наук, гл. науч. сотр., руководитель лаб. медицинской биофизики Университетской клиники ФГБОУ ВО ПИМУ Минздрава России

e-mail: cryst-mart@yandex.ru

cryst-mart@yandex.ruНещёткинаИрина АлександровнаNeshchetkinaIrina A.

Врач-терапевт отделения гипербарической оксигенации Университетской клиники ФГБОУ ВО ПИМУ Минздрава России

e-mail: irneshch@gmail.com

irneshch@gmail.comФедуловаЭльвира НиколаевнаFedulovaElvira N.

Доктор мед. наук, гл. науч. сотр., зав. 1-м педиатрическим отделением с медицинской реабилитацией Университетской клиники ФГБОУ ВО ПИМУ Минздрава России

e-mail: fedulova04@mail.ru

fedulova04@mail.ruЗагрековВалерий ИвановичZagrekovValeriy I.

Доктор мед. наук, гл. науч. сотр., руководитель отделения анестезиологии и реанимации Университетской клиники ФГБОУ ВО ПИМУ Минздрава России

e-mail: zagrekov@list.ru

zagrekov@list.ruФГБОУ ВО «Приволжский исследовательский медицинский университет» Минздрава РоссииPrivolzhsky Research Medical University202120022024246389394Copyright © Поповичева А.Н., Мартусевич А.К., Нещёткина И.А., Федулова Э.Н., Загреков В.И., 20242024Поповичева А.Н., Мартусевич А.К., Нещёткина И.А., Федулова Э.Н., Загреков В.И.Popovicheva A.N., Martusevich A.K., Neshchetkina I.A., Fedulova E.N., Zagrekov V.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rosped.ru/jour/article/view/393

Цель работы — определить изменения индексов эритроцитов и тромбоцитов при стандартной терапии воспалительных заболеваний кишечника (ВЗК) у детей и в комплексе с гипербарической оксигенацией (ГБО).

Материалы и методы

Материалы и методы. В работе использовали кровь 147 детей обоих полов в возрасте 6–17 лет, страдающих ВЗК: 76 — с болезнью Крона (БК), 71 — с неспецифическим язвенным колитом (ЯК). В комплекс лечения группы больных (16 с БК, 11 с ЯК) была включена терапия ГБО, проводившаяся в одноместной воздушно-кислородной барокамере «БароОкс 1.0». Курс составлял 5–8 ежедневных сеансов в режиме 1,3–1,4 атм в течение 40 мин. У всех пациентов определяли число тромбоцитов и индексы клеток крови: MCV, RDW, MCH, MCHC, MPV, PDW.

Результаты

Результаты. ВЗК у детей характеризуются значительным увеличением числа тромбоцитов, уменьшением MCV и MPV, возрастанием RDW и PDW. Применение ГБО в лечении ВЗК способствует увеличению MCV, МСНС, отмечается тенденция к снижению количества тромбоцитов.

Заключение

Заключение. Установленные нами закономерности изменений качественных и количественных характеристик клеток крови свидетельствуют о том, что применение ГБО в качестве дополнения к стандартному протоколу лечения ВЗК у детей способствует коррекции выявленных нарушений.

Участие авторов

Участие авторов:Поповичева А.Н. — концепция и дизайн исследования, написание текста;Поповичева А.Н., Федулова Э.Н., Нещёткина И.А., Загреков В.И. — сбор и обработка материала;Мартусевич А.К. — редактирование.Все соавторы — утверждение окончательного варианта статьи, ответственность за целостность всех её частей.

Финансирование

Финансирование. Исследование не имело финансовой поддержки.

Конфликт интересов

Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов.

Поступила 03

Поступила 03.12.2021Принята в печать 17.12.2021Опубликована 29.12.2021

 

 

The aim of this work is to determine changes in erythrocyte and platelet indices during standard therapy for inflammatory bowel diseases (IBD) in children and combination with hyperbaric oxygenation (HBO).

Materials and methods

Materials and methods. We used the blood of  147 children of both genders aged 6–17 years with IBD: 76 — with Crohn’s disease (CD), 71 — with ulcerative colitis (UC). The complex of treatment for patients (16 with CD, 11 with UC) included HBO therapy, which was carried out in a single air-oxygen pressure chamber «BaroOx 1.0». The course consisted of 5–8 daily sessions in the 1.3–1.4 atm regime for 40 minutes. The number of platelets and blood cell indices in all patients were determined: MCV, RDW, MCH, MCHC, MPV, PDW.

Results

Results. IBD in children is characterized by a significant increase in platelet count, a decrease in MCV and MPV, and an increase in RDW and PDW. The use of HBO in IBD treatment promotes an increase in MCV, MCHS and a tendency to decrease the number of platelets.

Conclusion

Conclusion. The patterns of changes in the qualitative and quantitative characteristics of blood cells that we have established indicate that the use of HBO to the standard treatment protocol for IBD in children contributes to the correction of the identified disorders.

Contribution

Contribution:Popovicheva A.N. — writing the text, concept and design of the study;Popovicheva A.N., Fedulova E.N., Neshetkina I.A., Zagrekov V.I. — collection and processing of the material;Martusevich A.K. — editing.All co-authors — Approval of the final version of the article, responsibility for the integrity of all its parts.

Acknowledgment

Acknowledgment. The study had no sponsorship.

Conflict of interest

Conflict of interest. The authors declare no conflict of interest.

Received

Received: December 03, 2021Accepted: December 17, 2021Published: December 29, 2021

 

 

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The authors declare that there are no conflicts of interest present.