The reproductive system of adolescent girls with Crohn’s disease after surgical interventions

Introduction. Crohn’s disease in girls is associated with a high risk of impaired sexual development and reproductive dysfunction. Surgical interventions required for complicated disease may further affect pelvic organs. Aim: to assess the reproductive system in girls with Crohn’s disease (CD) after surgical interventions.

Materials and methods. A prospective observational study included 56 CD girls aged of 3–17 years who underwent laparoscopic surgery. Anthropometric parameters, Tanner sexual development, menstrual function, gynecological status, pelvic ultrasound, frequency of adhesions and ovarian cysts were assessed. The course was analyzed before and after surgery.

Results. Before surgery, 53 patients had delayed sexual development, 34 had primary amenorrhea, 24 had pelvic adhesions, and 13 had ovarian cysts. Twelve months postoperatively, there was improvement in nutritional status, restoration of menstrual function in 49 of pubertal girls, reduced adhesions, and no recurrence of cysts.

Conclusions. Surgical treatment of CD in girls contributes to normalization of reproductive function, but requires long-term multidisciplinary follow-up.

Contribution:
Dyakonova E.Yu. — study concept and design;
Gusev A.A., Bekin A.S., Okulov E.A., Shchukina A.A., Tarzyan A.O. — material collection, surgical treatment;
Pereladova D.A. — data analysis, statistical processing.
All co-authors — approval of the final version of the article, responsibility for the integrity of all parts of the article.

Acknowledgment. The study had no sponsorship.

Conflict of interest. The authors declare no conflict of interest.

Received: July 02, 2025
Accepted: July 25, 2025
Published: August 28, 2025

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