Changes in the urinary system in children with enterovirus infection
https://doi.org/10.46563/1560-9561-2021-24-3-193-196
EDN: hxndhu
Abstract
A significant increase in the incidence of enterovirus infections (EVI) with the development of multiple organ damage does not exclude the involvement of the urinary system organs in the pathological process.
Materials and methods. 151 EVI children (103 cases with enterovirus meningitis (EVM), 48 children with other forms of EVI without damage of central nervous system) aged from 1 to 18 years. The frequency and nature of changes in urinary sediment and kidney function in patients with various EVI forms were studied. A highly sensitive marker of acute kidney injury — KIM-1 was used as a marker along with standard methods (determination of blood creatinine level with calculation of glomerular filtration rate) in 25 EVM patients.
Results. Pathological changes in urinary sediment in EVI are registered in 37.75% of cases (27.1–42.72%, depending on the clinical form), more often in preschool children, are represented by unexpressed proteinuria and abacterial leukocyturia, and are of a short-term transient nature. 40% of EVM children patients showed an increase in the KIM-1 level above the standard values.
Conclusion. The detection of KIM-1 in the urine of EVM children patients indicates the possible development of acute transient tubulointerstitial renal damage. At risk there are children with cerebrospinal fluid pleocytosis greater than 200×106/L, abacterial leukocyturia, and decreased glomerular filtration rate.
Contribution:
Kazartseva N.V., Kokoreva S.P. — research concept and design;
Kazartseva N.V. — collection and processing of material, statistical processing, text writing;
Kokoreva S.P. — editing.
All co-authors — approval of the final version of the article, responsibility for the integrity of all parts of the article.
Acknowledgment. The study had no sponsorship.
Conflict of interest. The authors declare no conflict of interest.
Received: June 18, 2021
Accepted: June 23, 2021
Published: July 16, 2021
About the Authors
Svetlana P. Kokoreva
N.N. Burdenko Voronezh State Medical University; Regional Children’s Clinical Hospital No. 2
Russian Federation
Russian Federation
MD, PhD, DSci., associate professor of the Department of children’s infectious diseases, Burdenko N.N. Voronezh State Medical University, Voronezh, 394036, Russian Federation
e-mail: kokorevasp@mail.ru
Natalya V. Kazartseva
Regional Children’s Clinical Hospital No. 2
Russian Federation
Russian Federation
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For citations:
Kokoreva S.P., Kazartseva N.V. Changes in the urinary system in children with enterovirus infection. Russian Pediatric Journal. 2021;24(3):193-196. (In Russ.) https://doi.org/10.46563/1560-9561-2021-24-3-193-196. EDN: hxndhu
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