Experimental determination of the safety of bioresorbable polylactate-coglycolide-based implants

Introduction. Treatment of bone fractures with growth zone disorders in children is an urgent task. Near- and intra-articular fractures are common injuries to the musculoskeletal system in children. However, the issue of choosing a safe retainer remains unresolved. Objective. To determine the safety of a bioresorbable polylactate-coglycolide (PLGA) implant for the surgical treatment of distal tibial metaepiphyseolysis in children.

Materials and methods. The work was performed on one hundred twenty white 3 months rats, weighing 110–120 g. The animals were divided into 2 groups: the main group consisted of 100 rats, 50 females and males each. Fragments of PLGA biopolymer were implanted intraperitoneally in animals of this group. The healing took place naturally. The control group consisted of 20 rats, 10 females and 10 males each, and no biopolymer was implanted in these animals. The observation was carried out for 3 months from the date of implantation.

Results. The PLGA-based implant had no adverse effect on the condition of the animals, and there were no signs of inflammation. After 3 months, the implant was destroyed in the abdominal cavity of the animals. There were no significant deviations in the condition of the animals, a decrease in their body weight, or changes in blood tests.

Conclusion. A biopolymer based on PLGA can be used as a bioresorbable fixative for near- and intra-articular bone fractures.

Contributions:
Serova N.Yu., Yatsyk S.P., Chelpachenko O.B., Artifeksova A.A. — concept and design of the study;
Serova N.Yu., Lushnikov A.M. — collection and processing of material, statistical processing of the material;
Serova N.Yu., Chelpachenko O.B. — writing the text;
Serova N.Yu., Chelpachenko O.B., Artifeksova A.A. — editing the text.
All co-authors — approval of the final version of the article, responsibility for the integrity of all parts of the article.

Acknowledgment. The study had no sponsorship.

Conflict of interest. The authors declare no conflict of interest.

Received: March 04, 2025
Accepted: March 18, 2025
Published: April 29, 2025

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