Platelets-enriched plasma: experience of application in pediatric practice

With the development of biomedical technologies, new promising treatment methods are emerging. In the field of regenerative medicine, such technology is represented by therapy with Platelet Rich Plasma (PRP), an innovative technology for the treatment of joints, muscles, and tendons, in which autologous platelets-rich plasma (autoplasm) is injected into the affected area, isolated from the patient’s blood. The principle of treatment is based on the delivery of natural factors involved in the recovery processes to the affected area. The aim of the review is to determine the range of the use of PRP therapy in pediatric practice. We conducted a literature search in the following databases: PubMed, Embase, Cochrane Library, Google. This review includes studies from 2019 to 2024. PRP therapy has earned high expectations for its ability to stimulate natural regeneration processes and accelerate tissue regeneration at the cellular level. Due to its analgesic properties, this technique is used not only in surgical practice during the postoperative period, but also in other related areas. However, all advanced technologies require careful study and accumulation of data with subsequent introduction into a clinical setting, which in this case is no exception. Therefore, the scientific and practical development of this area is very relevant now. The main obstacles to the widespread use of PRP therapy are the insufficient amount of data and its inert analysis. Provided that the analysis of this technology is actively carried out at various levels and in sufficient volume, we will make extensive use of this promising treatment technique in the foreseeable future. 

Contribution:
Sibirskaya E.V. — development of the concept and design of the study;
Nikiforova P.O. — analysis of results, editing the text;
Mantseva A.V. — writing the text, reviewing publications on the topic of the article, analyzing the obtained data;
Mancev A.O. — writing the text, reviewing publications on the topic of the article;
Sharkov S.M. — editing the text.
All co-authors — approval of the final version of the article, responsibility for the integrity of all parts of the article.

Acknowledgment. The study had no sponsorship.

Conflict of interest. The authors declare no conflict of interest.

Received: December 25, 2024
Accepted: March 18, 2025
Published: April 29, 2025

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