Динамика индикаторов эндотелиальной дисфункции при ожирении у детей

Введение. Конституционально-экзогенное ожирение (КЭО) относится к ряду значимых медико-социальных проблем современного мира, принимает масштабы эпидемии и лидирует среди алиментарно-зависимой патологии у детей.

Цель работы — изучение изменений индикаторов эндотелиальной дисфункции при различной выраженности ожирения у детей.

Материалы и методы. Комплексно обследованы 126 детей в возрасте 6–17 лет, из них 110 пациентов с различной выраженностью КЭО. В сыворотке крови определяли содержание медиаторов эндотелиальной дисфункции: оксида азота, эндотелина-1, лептина, гомоцистеина, молекул межклеточной адгезии и  адгезии сосудистых клеток-1, антигена ингибитора активатора плазминогена тканевого типа, фактора Виллебранда и его антигена.

Результаты. Установлены закономерности изменений концентраций указанных соединений в крови в зависимости от возраста больных и степени ожирения, отражающие нарушения функционального состояния эндотелиальной системы. 

Заключение. Индикаторы эндотелиальной дисфункции могут служить критериями её выраженности, их выявление позволит оптимизировать раннюю диагностику и определить объём своевременной терапии.

Участие авторов:
Смирнов И.Е., Кучеренко А.Г. — концепция и дизайн исследования;
Кучеренко А.Г., Постникова Е.В., Смирнова Г.И. — cбор материала;
Кучеренко А.Г., Смирнов И.Е. — cтатистическая обработка;
Смирнов И.Е. — написание текста;
Фисенко А.П. — редактирование.
Все соавторы — утверждение окончательного варианта статьи, ответственность за целостность всех частей статьи.

Финансирование. Исследование не имело финансовой поддержки.

Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов. 

Поступила 25.04.2022
Принята к печати 26.04.2022
Опубликована 07.05.2022

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