Mathematical modelling in the study of the pathogenesis of viral hepatitis in children
https://doi.org/10.46563/1560-9561-2022-25-1-28-31
EDN: fyihcf
Abstract
The aim of the work is to form a mathematical model of viral hepatitis based on structural modelling, discriminant and factorial analysis of laboratory parameters of patients.
Materials and methods. The data array included the results of a comprehensive laboratory testing of 109 children with viral hepatitis B and C (33 parameters).
Results. Seven main factors in the pathogenesis of viral hepatitis in children reflect the severity of endogenous intoxication and disorders of protein metabolism, modification of the mode of functioning of enzymes, and supramolecular multi-enzyme complexes in conditions of progression of the first two components.
Conclusion. The identified factors of the pathogenesis of viral hepatitis may reflect the endogenous intoxication during disease progression, the state of detoxification enzyme systems, and the further fibrotic changes in the liver.
Contribution:
Martusevich A.K. — the concept and design of the study, the collection and processing of material, writing the text;
Galova E.A. — providing material for research;
Korkotashvili L.V. — carrying out mathematical modeling;
Popovicheva A.N. — editing the text of the article.
Аll co-authors — аpproval of the final version of the article, responsibility for the integrity of all parts of the article.
Informed consent: informed consent was received from the patients parents for the publication of a description of the clinical case.
Acknowledgment. The study had no sponsorship.
Conflict of interest. The authors declare no conflict of interest.
Received: January 14, 2022
Accepted: February 17, 2022
Published: March 15, 2022
About the Authors
Andrey K. Martusevich
Privolzhsky Research Medical University
Russian Federation
Russian Federation
Elena A. Galova
Privolzhsky Research Medical University
Russian Federation
Russian Federation
Aleksandra N. Popovicheva
Privolzhsky Research Medical University
Russian Federation
Russian Federation
Junior researcher, Laboratory of medical biophysics of the University Clinic, Privolzhsky Research Medical University, Nizhny Novgorod, 603950, Russian Federation.
e-mail: alexandra.popovichus@yandex.ru
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Review
For citations:
Martusevich A.K., Galova E.A., Popovicheva A.N. Mathematical modelling in the study of the pathogenesis of viral hepatitis in children. Russian Pediatric Journal. 2022;25(1):28-31. (In Russ.) https://doi.org/10.46563/1560-9561-2022-25-1-28-31. EDN: fyihcf
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