The application of domestic specialized mixtures for enteral nutrition in children with bronchopulmonary pathology
https://doi.org/10.46563/1560-9561-2021-24-2-78-85
EDN: ykffzk
Abstract
Adequately organized nutritional support allows avoiding the development of protein-energy malnutrition in patients with bronchopulmonary diseases and cystic fibrosis (CF). The satisfying of increased protein and energy needs of CF patients can only be implemented under the administration.
The aim of the study is to analyze the tolerance and effectiveness of the use of domestic sterilized liquid specialized high-protein high-calorie mixtures «Nutrien Pulmo» and «Nutrien Energiya with Dietary Fibers» in children over three years of age with acute (pneumonia) and chronic (cystic fibrosis) forms of bronchopulmonary pathology.
Patients and methods. Fifty-five children, including 41 patient suffered from CF, 14 cases with pneumonia, aged from 3 to 18years, were under observation. Of these, 23 (42%) children received Nutrien Pulmo, 32 (58%) children received Nutrien Energiya with Dietary Fibers. Nutritional status was assessed using the WHO-Anthro programs (for children from 3 to 5 years old) and WHO-Anthro Plus (for patients over five years) and clinical and biochemical blood test indices. The observation period was accounted for three weeks.
Results. All patients highly appreciated the taste of the products, there were no refusals to take specialized mixtures, neither adverse events during the observation period. While taking specialized mixtures, there was a positive trend in anthropometric indices and a significant improvement in biochemical markers of nutritional status: an increase in prealbumin, total protein, transferrin level.
Conclusion. The use of specialized domestic products «Nutrien Pulmo» and «Nutrien Energiya with Dietary Fibers» in the diet therapy of children with acute and chronic bronchopulmonary pathology has the safe and positive effect on the nutritional status of patients.
Contribution:
Bushueva T.V., Simonova O.I., Borovik T.E., Roslavtseva E.A. — the concept and design of the study;
Shen N.P., Tsiryatieva S.B., Lyabina N.V., Sokolov I.V., Burkina N.I., Chernyavskaya A.S. — collection of material;
Shen N.P., Tsiryatieva S.B., Bushueva T.V. — statistical treatment;
Bushueva T.E., Borovik T.E., Roslavtseva E.A. — writing text.
All co-authors — approval of the final version of the article, responsibility for the integrity of all parts of the article.
Acknowledgment. The study had no sponsorship.
Conflict of interest. The authors declare no conflict of interest.
Received: March 22, 2021
Accepted: April 22, 2021
Published: May 14, 2021
About the Authors
Tatyana V. BushuevaRussian Federation
MD, Ph.D., DSci., leading researcher of the National Medical Research Center for Children’s Health, Moscow, 119991, Russian Federation
e-mail: tbushueva1@yandex.ru
Tatyana E. Borovik
Russian Federation
Elena A. Roslavtseva
Russian Federation
Natalya P. Shen
Russian Federation
Svetlana B. Tsiryatyeva
Russian Federation
Olga I. Simonova
Russian Federation
Nina I. Burkina
Russian Federation
Nadezhda V. Lyabina
Russian Federation
Ina V. Sokolov
Russian Federation
Anastasiya S. Chernyavskaya
Russian Federation
References
1. Lusman S., Sullivan J. Nutrition and growth in cystic fibrosis. Pediatr. Clin. North Am. 2016; 63(4): 661–78. https://doi.org/10.1016/j.pcl.2016.04.005.
2. Brownell J.N., Bashaw H., Stallings V.A. Growth and nutrition in cystic fibrosis. Semin. Respir. Crit. Care Med. 2019; 40(6): 775–91. https://doi.org/10.1055/s-0039-1696726
3. Dhochak N., Jat K.R., Sankar J., Lodha R., Kabra S.K. Predictors of malnutrition in children with cystic fibrosis. Indian Pediatr. 2019; 56(10): 825–30.
4. Kapnadak S.G., Dimango E., Hadjiliadis D., Hempstead S.E., Tallarico E., Pilewski J.M., et al. Cystic Fibrosis Foundation consensus guidelines for the care of individuals with advanced cystic fibrosis lung disease. J. Cyst. Fibros. 2020; 19(3): 344–54. https://doi.org/10.1016/j.jcf.2020.02.015
5. Vasil’eva E.M., Bakanov M.I., Smirnov I.E., Bogatyreva A.O., Simonova O.I. Changes in the content of microelements and oxidative stress indices in children with chronic bronchopulmonary pathology. Rossiyskiy pediatricheskiy zhurnal. 2017; 20(6): 339–45. https://doi.org/10.18821/1560-9561-2017-20-6-339-345 (in Russian)
6. Roslavtseva E.A., Borovik T.E., Simonova O.I., Ignatova A.S. Peculiarities of nutrition in children with mucoviscidosis. Voprosy sovremennoy pediatrii. 2010; 9(1): 162–7. (in Russian)
7. Umławska W., Krzyżanowska M., Zielińska A., Sands D. Effect of selected factors associated with the clinical course of the disease on nutritional status in children with cystic fibrosis. Adv. Clin. Exp. Med. 2014; 23(5): 775–83. https://doi.org/10.17219/acem/37251
8. Stallings V.A., Stark L.J., Robinson K.A., Feranchak A.P., Quinton H. Evidence-based practice recommendations for nutrition-related management of children and adults with cystic fibrosis and pancreatic insufficiency: results of a systematic review. J. Am. Diet. Assoc. 2008; 108(5): 832–9. https://doi.org/10.1016/j.jada.2008.02.020
9. Borovik T.E., Ladodo K.S., eds. Clinical Dietetics of Childhood: A Guide for Doctors [Klinicheskaya dietologiya detskogo vozrasta: Rukovodstvo dlya vrachey]. Moscow: MIA; 2015. (in Russian)
10. National Consensus «Cystic Fibrosis: definition, diagnostic criteria, therapy». Moscow; 2016. Available at: https://mukoviscidoz.org/doc/konsensus/CF_consensus_2017.pdf (in Russian)
11. Singh V.K., Schwarzenberg S.J. Pancreatic insufficiency in Cystic Fibrosis. J. Cyst. Fibros. 2017; 16(Suppl. 2): 70–8. https://doi.org/10.1016/j.jcf.2017.06.011
12. Smirnov I.E., Kustova O.V., Sorokina T.E., Kucherenko A.G. Markers of fibrosis in chronic bronchopulmonary diseases in children. Rossiyskiy pediatricheskiy zhurnal. 2015; 18(1): 14–20. (in Russian)
13. Smirnov I.E., Tarasova O.V., Lukina O.F., Kustova O.V., Sorokina T.E., Simonova O.I. Structural and functional state of the lungs in cystic fibrosis in children. Rossiyskiy pediatricheskiy zhurnal. 2015; 18(2): 11–7. (in Russian)
14. Le T.N., Anabtawi A., Putman M.S., Tangpricha V., Stalvey M.S. Growth failure and treatment in cystic fibrosis. J. Cyst. Fibros. 2019; 18(Suppl. 2): 82–7. https://doi.org/10.1016/j.jcf.2019.08.010
15. Shimmin D., Lowdon J., Remmington T. Enteral tube feeding for cystic fibrosis. Cochrane Database Syst. Rev. 2019; 7(7): CD001198. https://doi.org/10.1002/14651858.CD001198.pub5
16. Schwarzenberg S.J., Hempstead S.E., McDonald C.M., Powers S.W., Wooldridge J., Blair S., et al. Enteral tube feeding for individuals with cystic fibrosis: Cystic Fibrosis Foundation evidence-informed guidelines. J. Cyst. Fibros. 2016; 15(6): 724–35. https://doi.org/10.1016/j.jcf.2016.08.004
17. Altman K., McDonald C.M., Michel S.H., Maguiness K. Nutrition in cystic fibrosis: From the past to the present and into the future. Pediatr. Pulmonol. 2019; 54(Suppl. 3): 56–73. https://doi.org/10.1002/ppul.24521
18. Sullivan J.S., Mascarenhas M.R. Nutrition: Prevention and management of nutritional failure in Cystic Fibrosis. J. Cyst. Fibros. 2017; 16(Suppl 2): 87–93. https://doi.org/10.1016/j.jcf.2017.07.010
19. Ciofu O., Smith S., Lykkesfeldt J. Antioxidant supplementation for lung disease in cystic fibrosis. Cochrane Database Syst. Rev. 2019; 10(10): CD007020. https://doi.org/10.1002/14651858
20. Haupt M.E., Kwasny M.J., Schechter M.S., McColley S.A. Pancreatic enzyme replacement therapy dosing and nutritional outcomes in children with cystic fibrosis. J. Pediatr. 2014; 164(5): 1110–5. https://doi.org/10.1016/j.jpeds.2014.01.022
21. Lavi E., Gileles-Hillel A., Zangen D. Somatic growth in cystic fibrosis. Curr. Opin. Endocrinol. Diabetes Obes. 2020; 27(1): 38–46. https://doi.org/10.1097/MED.0000000000000522
22. Borschuk A.P., Filigno S.S., Opipari-Arrigan L., Peugh J., Stark L.J. Psychological predictors of nutritional adherence in adolescents with cystic fibrosis. Clin. Nutr. ESPEN. 2019; 33: 143–7. https://doi.org/10.1016/j.clnesp.2019.06.004
23. Alshaikh B., Schall J.I., Maqbool A., Mascarenhas M., Bennett M.J., Stallings V.A. Choline supplementation alters some amino acid concentrations with no change in homocysteine in children with cystic fibrosis and pancreatic insufficiency. Nutr. Res. 2016; 36(5): 418–29. https://doi.org/10.1016/j.nutres.2015.12.014
24. Souza Dos Santos Simon M.I., Forte G.C., da Silva Pereira J., da Fonseca Andrade Procianoy E., Drehmer M. Validation of a nutrition screening tool for pediatric patients with cystic fibrosis. J. Acad. Nutr. Diet. 2016; 116(5): 813–8. https://doi.org/10.1016/j.jand.2016.01.012
25. Smirnova G.I., Mankute G.R. Intestinal microbiota and atopic dermatitis in children. Rossiyskiy pediatricheskiy zhurnal. 2015; 18(6): 46–53. (in Russian)
26. Huang Y.J., LiPuma J.J. The microbiome in cystic fibrosis. Clin, Chest, Med. 2016; 37(1): 59–67. https://doi.org/10.1016/j.ccm.2015.10.003
27. Smirnova G.I. Gut microbiota and the use of probiotics in the prevention and treatment of atopic dermatitis in children. Lechashchiy vrach. 2016; 58(1): 6–11. (in Russian)
28. Vernocchi P., Del Chierico F., Russo A., Majo F., Rossitto M., Valerio M., et al. Gut microbiota signatures in cystic fibrosis: Loss of host CFTR function drives the microbiota enterophenotype. PLoS One. 2018; 13(12): e0208171. https://doi.org/10.1371/journal.pone.0208171
29. Zhang D., Li S., Wang N., Tan H.Y., Zhang Z., Feng Y. The cross-talk between gut microbiota and lungs in common lung diseases. Front. Microbiol. 2020; 11: 301. https://doi.org/10.3389/fmicb.2020.00301
30. Gaskin K.J. Nutritional care in children with cystic fibrosis: are our patients becoming better? Eur. J. Clin. Nutr. 2013; 67(5): 558–64. https://doi.org/10.1038/ejcn.2013.20
31. Regelmann W.E., Schechter M.S., Wagener J.S., Morgan W.J., Pasta D.J., Elkin E.P., et al. Pulmonary exacerbations in cystic fibrosis: young children with characteristic signs and symptoms. Pediatr. Pulmonol. 2013; 48(7): 649–57. https://doi.org/10.1002/ppul.22658
32. Papalexopoulou N., Dassios T.G., Lunt A., Bartlett F., Perrin F., Bossley C.J., et al. Nutritional status and pulmonary outcome in children and young people with cystic fibrosis. Respir. Med. 2018; 142: 60–5. https://doi.org/10.1016/j.rmed.2018.07.016
33. Turck D., Braegger C.P., Colombo C., Declercq D., Morton A., Pancheva R., et al. ESPEN-ESPGHAN-ECFS guidelines on nutrition care for infants, children, and adults with cystic fibrosis. Clin. Nutr. 2016; 35(3): 557–77. https://doi.org/10.1016/j.clnu.2016.03.004
34. Smyth R.L., Rayner O. Oral calorie supplements for cystic fibrosis. Cochrane Database Syst. Rev. 2017; 5(5): CD000406. https://doi.org/10.1002/14651858.CD000406.pub5
35. Roslavtseva E.A., Bushueva T.V., Borovik T.E., Simonova O.I., Burkina N.I., Lokhmatov M.M. The possibilities of using the domestic mixture for enteral nutrition in the correction of the undernutrition in cystic fibrosis children. Rossiyskiy pediatricheskiy zhurnal. 2019; 22(2): 75–80. https://doi.org/10.18821/1560-9561-2019-22-2-75-80 (in Russian)
36. Bell S.C., Mall M.A., Gutierrez H., Macek M., Madge S., Davies J.C., et al. The future of cystic fibrosis care: a global perspective. Lancet Respir. Med. 2020; 8(1): 65–124. https://doi.org/10.1016/S2213-2600(19)30337-6
Review
For citations:
Bushueva T.V., Borovik T.E., Roslavtseva E.A., Shen N.P., Tsiryatyeva S.B., Simonova O.I., Burkina N.I., Lyabina N.V., Sokolov I.V., Chernyavskaya A.S. The application of domestic specialized mixtures for enteral nutrition in children with bronchopulmonary pathology. Russian Pediatric Journal. 2021;24(2):78-85. (In Russ.) https://doi.org/10.46563/1560-9561-2021-24-2-78-85. EDN: ykffzk