Preview

Russian Pediatric Journal

Advanced search

Diagnostic possibilities of magnetic resonance imaging in inflammatory bowel diseases in children

https://doi.org/10.46563/1560-9561-2025-28-3-231-236

EDN: wlxanu

Abstract

Introduction. Magnetic resonance imaging (MRI) is a modern diagnostic method aimed at detecting pathological changes in tissues and internal organs. MRI possesses of significant diagnostic potential in inflammatory bowel diseases (IBD) in children. An alternative to endoscopic examination is MR enterography, a non-invasive technique that is not associated with ionizing radiation, which allows determining not only the condition of the intestinal wall throughout, including thickness and changes in the lumen, but also identifying extra-intestinal complications, as well as the response to treatment.

The aim of the work is to determine the diagnostic capabilities of magnetic resonance imaging in IBD in children. To analyze the literature, a search was conducted in the databases PubMed, MedLine, Google Scholar, and RSCI over the past 10 years. The most important advantage of MRI is its non-invasiveness, which is welcome when examining children of different ages. To improve the image quality during MRI, contrast is used, and various modes are used without a contrast agent. The indices for assessing intestinal inflammatory activity and perinatal complications on MRI closely correlate with the reference endoscopic data. MRI is widely used not only as a diagnostic tool for IBD in children, but also as a method of dynamic patient monitoring to evaluate the effectiveness of therapy.

Conclusion. MRI is one of the most accurate and informative diagnostic methods along with endoscopic examination. The advantage of the method is its non-invasiveness, which makes it more accessible for use in clinical practice, especially in children, as well as the ability to assess the condition of anatomical structures that are difficult to reach with an endoscope.

Contribution:
Gorelova E.S., Anikin A.V., Usoltseva O.V., Potapov A.S. — concept and design of the study;
Gorelova E.S. — collection and processing of the material;
Gorelova E.S., Anikin A.V. — writing the text;
Gorelova E.S., Usoltseva O.V., Anikin A.V., Potapov A.S. — editing the text.
All co-authors — approval of the final version of the article, responsibility for the integrity of all parts of the article.

Acknowledgment. The study had no sponsorship.

Conflict of interest. The authors declare no conflict of interest.

Received: April 22, 2025
Accepted: May 20, 2025
Published: June 27, 2025

About the Authors

Elena S. Gorelova
National Medical Research Center for Children’s Health
Russian Federation

Resident for second year of study on specialties pediatrics, National Medical Research Center for Children’s Health Federal state autonomous institution of the Russian Federation Ministry of Health

e-mail: kozminysha@yandex.ru



Anatoly V. Anikin
National Medical Research Center for Children’s Health
Russian Federation


Olga V. Usoltseva
National Medical Research Center for Children’s Health
Russian Federation


Alexander S. Potapov
National Medical Research Center for Children’s Health; Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation


References

1. Wang Y., Zhang R., Mao R., Li X. Inflammatory bowel disease cross-sectional imaging: What’s new? United European Gastroenterol. J. 2022; 10(10): 1179–93. https://doi.org/10.1002/ueg2.12343

2. Kuenzig M., Fung S., Marderfeld L., Mak J., Kaplan G., Ng S., et al. Twenty-first century trends in the global epidemiology of pediatric-onset inflammatory bowel disease: systematic review. Gastroenterology. 2022; 162(4): 1147–59.e4. https://doi.org/10.1053/j.gastro.2021.12.282

3. Prokhorenkova M.O., Nosenko K.M., Orlova M.A., Vinokurova A.V., Kazakova V.A., Koroleva O.A., et al. Diagnostic delay in inflammatory bowel diseases in children. Rossiyskiy pediatricheskiy zhurnal. 2023; 26(6): 399–407. https://doi.org/10.46563/1560-9561-2023-26-6-399-407 https://elibrary.ru/nkdaxe (in Russian)

4. Vernon-Roberts A., Aluzaite K., Khalilipour B., Day A. Systematic review of diagnostic delay for children with inflammatory bowel disease. J. Pediatr. Gastroenterol. Nutr. 2023; 76(3): 304–12. https://doi.org/10.1097/MPG.0000000000003670

5. Yamamoto-Furusho J.K., Parra-Holguín N.N. Diagnostic delay of inflammatory bowel disease is significantly higher in public versus private health care system in Mexican patients. Inflamm. Intest. Dis. 2022; 7(2): 72–80. https://doi.org/10.1159/000520522

6. Kucharzik T., Tielbeek J., Carter D., Taylor S., Tolan D., Wilkens R., et al. ECCO-ESGAR topical review on optimizing reporting for cross-sectional imaging in inflammatory bowel disease. J. Crohns Colitis. 2022; 16(4): 523–43. https://doi.org/10.1093/ecco-jcc/jjab180

7. Tao Y., Li H., Xu H., Tang W., Fan G., Yang X. Can the simplified magnetic resonance index of activity be used to evaluate the degree of activity in Crohn’s disease? BMC Gastroenterology. 2021; 21(1): 409. https://doi.org/10.1186/s12876-021-01987-z

8. Gordon H., Minozzi S., Kopylov U., Verstockt B., Chaparro M., Buskens C., et al. ECCO guidelines on therapeutics in Crohn’s disease: medical treatment. J. Crohns Colitis. 2024; 18(10): 1531–55. https://doi.org/10.1093/ecco-jcc/jjae091

9. Wang W., Sung C., Wang S., Shao Y. Risks of leukemia, intracranial tumours and lymphomas in childhood and early adulthood after pediatric radiation exposure from computed tomography. CMAJ. 2023; 195(16): E575–83. https://doi.org/10.1503/cmaj.221303

10. Karkoshka T.A., Nelasov N.Yu. The role of ultrasound and another imaging diagnostic methods in the detection of inflammatory bowel diseases in children. Mezhdunarodnyy nauchno-issledovatel’skiy zhurnal. 2021; (3-2): 86–91. https://doi.org/10.23670/IRJ.2021.105.3.039 https://elibrary.ru/bhvbsx (in Russian)

11. Gee M., Nimkin K., Hsu M., Israel E., Biller J., Katz A., et al. Prospective evaluation of MR enterography as the primary imaging modality for pediatric Crohn disease assessment. AJR Am. J. Roentgenol. 2011; 197(1): 224–31. https://doi.org/10.2214/AJR.10.597

12. Al-Ani A.H., Vaughan R., Christensen B., Bryant R.V., Novak K.L. Treat to transmural healing: how to incorporate intestinal ultrasound into the treatment of inflammatory bowel disease. Br. J. Radiol. 2022; 95(1137): 20211174. https://doi.org/10.1259/bjr.20211174

13. van Rheenen P.F., Aloi M., Assa A., Bronsky J., Escher J.C., Fagerberg U.L., et al. The medical management of paediatric Crohn’s disease: an ECCO-ESPGHAN guideline update. J. Crohns Colitis. 2020; jjaa161. https://doi.org/10.1093/ecco-jcc/jjaa161

14. Morozova T.G., Gelt T.D., Kovaljov A.V. The possibilities of diagnostics radiology methods in the complicated course of the intestine tumor. Clinical Observation. Radiologiya – praktika. 2025; (1): 77–87. https://doi.org/10.52560/2713-0118-2025-1-77-87 https://elibrary.ru/pbohyt (in Russian)

15. Lokhmatov M.M., Budkina T.N., Khavkin A.I., Tupylenko A.V., Oldakovsky V.I. Draft clinical guidelines for endoscopic diagnosis of ulcerative colitis in children. Eksperimental’naya i klinicheskaya gastroenterologiya. 2022; (1): 87–98. https://doi.org/10.31146/1682-8658-ecg-197-1-87-98 https://elibrary.ru/ovkont (in Russian)

16. Chatterji M., Fidler J.L., Taylor S.A., Anupindi S.A., Yeh B.M., Guglielmo F.F. State of the Art MR enterography technique. Top Magn. Reson. Imaging. 2021; 30(1): 3–11. https://doi.org/10.1097/RMR.0000000000000263

17. Otochkin V.V., Rozengauz E.V., Chernyshev M.D., Shevkunova L.G. Methodological aspects of performing MR-enterography for Crohn’s disease: what is important for a diagnostician? Meditsinskaya vizualizatsiya. 2022; 26(3): 105–13. https://doi.org/10.24835/1607-0763-1129 https://elibrary.ru/vunilr (in Russian)

18. Zulkifle A.F., Siti Soraya A.R., Hamzaini A.H. Comparison of pineapple juice and mannitol as oral contrast agents for magnetic resonance enterography. Med. J. Malaysia. 2023; 78(6): 774–9.

19. Dillman J.R., Anupindi S.A., Dane B. Proposal of an abbreviated noncontrast MR enterography protocol for patients with Crohn disease. AJR Am. J. Roentgenol. 2024; 222(2): e2330422. https://doi.org/10.2214/AJR.23.30422

20. Cicero G., Alibrandi A., Blandino A., Ascenti V., Fries W., Viola A., et al. DWI ratios: New indexes for Crohn’s disease activity at magnetic resonance enterography? Radiol. Med. 2022; 128(1): 16–26. https://doi.org/10.1007/s11547-022-01573-7

21. Hameed M., Taylor S.A., Ahmed N., Chowdhury K., Patel A., Helbren E., et al. Diffusion-weighted imaging to predict longer-term response in Crohn’s disease patients commencing biological therapy: results from the MOTILITY trial. Br. J. Radiol. 2025; 98(1168): 527–34. https://doi.org/10.1093/bjr/tqaf013

22. Shelygin Yu.A., Vasiliev S.V., Veselov A.V., Groshilin V.S., Kashnikov V.N., Korolik V.U., et al. Anal fistula. Koloproktologiya. 2020; 19(3): 10–25. https://doi.org/10.33878/2073-7556-2020-19-3-10-25 https://elibrary.ru/uzrgla (in Russian)

23. Maino C., Mariani I., Drago S.G., Franco P.N., Giandola T.P., Donati F., et al. Computed tomography and magnetic resonance enterography: from protocols to diagnosis. Diagnostics (Basel). 2024; 14(22): 2584. https://doi.org/10.3390/diagnostics14222584

24. Halligan S. Magnetic resonance imaging of fistula-in-ano. Magn. Reson. Imaging. Clin. N. Am. 2020; 28(1): 141–51. https://doi.org/10.1016/j.mric.2019.09.006

25. Greer M.L.C., Taylor S.A. Perianal imaging in Crohn disease: current status with a focus on MRI, from the AJR special series on imaging of inflammation. AJR Am. J. Roentgenol. 2022; 218(5): 781–92. https://doi.org/10.2214/AJR.21.26615

26. Rimola J. Torres J., Kumar S., Taylor S.A., Kucharzik T. Recent advances in clinical practice: advances in cross-sectional imaging in inflammatory bowel disease. Gut. 2022; 71(12): 2587–97. https://doi.org/10.1136/gutjnl-2021-326562

27. Li X., Mao R., Huang S.Y., Sun C.H., Cao Q.H., Fang Z.N., et al. Characterization of degree of intestinal fibrosis in patients with Crohn disease by using magnetization transfer MR imaging. Radiology. 2018; 287(2): 494–503. https://doi.org/10.1148/radiol.2017171221

28. Usoltseva O.V., Surkov A.N., Movsisyan G.B., Kulebina E.A., Simersina S.A., Potapov A.S., et al. Primary sclerosing cholangitis in children with inflammatory bowel disease. Rossiyskiy Pediatricheskiy Zhurnal. 2022; 24(6): 395–404. https://elibrary.ru/nivztu (in Russian)

29. Zarodnyuk I.V., Eligulashvili R.R., Veselov V.V., Mikhalchenko V.A., Nanaeva B.A., Vardanyan A.V., et al. Assessment of inflammation activity in the small and large bowel using the MaRIAs index for Crohn’s disease. Koloproktologiyа. 2023; 22(4): 71–9. https://doi.org/10.33878/10.33878/2073-7556-2022-21-4-39-48 https://elibrary.ru/emxldo (in Russian)

30. Ordás I., Rimola J., Alfaro I., Rodríguez S., Castro-Poceiro J., Ramírez-Morros A., et al. Development and validation of a simplified magnetic resonance index of activity for Crohn’s disease. Gastroenterology. 2019; 157(2): 432–9. https://doi.org/10.1053/j.gastro.2019.03.051

31. Na J.E., Kim H.S., Hong S.N., Song K.D., Kim J.E., Kim E.R., et al. Comparison of an endoscopic scoring system and the simplified magnetic resonance index of activity in patients with small bowel Crohn’s disease. Gut Liver. 2024; 18(1): 97–105. https://doi.org/10.5009/gnl220422

32. Choshen S., Turner D., Pratt L.T., Precel R., Greer M.L., Castro D.A., et al. Development and validation of a pediatric MRI-Based perianal Crohn disease (PEMPAC) index – a report from the ImageKids Study. Inflamm. Bowel. Dis. 2022; 28(5): 700–9. https://doi.org/10.1093/ibd/izab147

33. Gordic S., Bane O., Kihira S., Peti S., Hectors S., Torres J., et al. Evaluation of ileal Crohn’s disease response to TNF antagonists: Validation of MR enterography for assessing response. Initial results. Eur. J. Radiol. Open. 2020; 7: 100217. https://doi.org/10.1016/j.ejro.2020.01.006

34. Gladkikh M., Benchimol E.I., Mack D.R., Mojaverian N., Highmore K., Miller E., et al. MR enterography scores correlate with degree of mucosal healing in pediatric Crohn’s disease: a pilot study. J. Can. Assoc. Gastroenterol. 2023; 6(3): 125–30. https://doi.org/10.1093/jcag/gwad010

35. Roseira J., Ventosa A.R., de Sousa H.T., Brito J. The new simplified MARIA score applies beyond clinical trials: A suitable clinical practice tool for Crohn’s disease that parallels a simple endoscopic index and fecal calprotectin. United European Gastroenterol. J. 2020; 8(10): 1208–16. https://doi.org/10.1177/2050640620943089

36. Radiopaedia.org. Botz B., Knipe H., Foster T. Magnetic resonance index of activity (Crohn disease); 2021. Available at: https://radiopaedia.org/articles/94209

37. Puylaert C., Nolthenius C., Tielbeek J., Makanyanga J., Rodriguez-Justo M., Brosens L., et al. Comparison of MRI activity scoring systems and features for the terminal ileum in patients with Crohn disease. AJR Am. J. Roentgenol. 2019; 212(2): W25–31. https://doi.org/10.2214/AJR.18.19876

38. Yao J., Zhou J., Zhong Y., Zhang М., Peng Х., Zhao J., et al. Computed tomography-based radiomics nomogram using machine learning for predicting 1-year surgical risk after diagnosis of Crohn’s disease. Med. Phys. 2023; 50(6): 3862–72. https://doi.org/10.1002/mp.16402

39. Ruiqing L., Jing Y., Shunli L., Jia K., Zhibo W., Hongping Z., et al. A novel radiomics model integrating luminal and mesenteric features to predict mucosal activity and surgery risk in Crohn’s disease patients: A Multicenter Study. Acad. Radiol. 2023; 30(Suppl. 1): 207–19. https://doi.org/10.1016/j.acra.2023.03.023


Review

For citations:


Gorelova E.S., Anikin A.V., Usoltseva O.V., Potapov A.S. Diagnostic possibilities of magnetic resonance imaging in inflammatory bowel diseases in children. Russian Pediatric Journal. 2025;28(3):231-236. (In Russ.) https://doi.org/10.46563/1560-9561-2025-28-3-231-236. EDN: wlxanu

Views: 50


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1560-9561 (Print)
ISSN 2413-2918 (Online)