Quality of life in children with hemorrhagic syndrome, taking into account the level of homocysteine in blood plasma

Introduction. The quality of life is an integral characteristic of the vital activity, which covers in patients the social, physical, and psychological functioning. The quality of life is defined as a person’s individual relationship to their position in life (culture, values, plans and goals in this person, opportunities and degree of disorder). Aim: to determine changes in the parameters of the quality of life of children with hemorrhagic syndrome, taking into account the level of homocysteine in blood plasma.
Materials and methods. There were examined ninety seven children aged of 13–17 years. The main group consisted of 30 adolescents with clinical manifestations of hemorrhagic syndrome. The control group consisted of 67 children without signs of bleeding. The children of both groups were comparable in gender and age. The quality of life was assessed using a valid randomized questionnaire, the Pediatric Quality of Life Questionnaire PedsQL4.0 for adolescents. There were assessed following parameters of functioning: physical, emotional, social, school and psychosocial health. Based on the data obtained, the total score was calculated. All the data received has been processed statistically.
Results. The highest indicators of the quality of life were obtained in children of the control group on the scales of social and physical functioning. The indicators of quality of life in children with hemorrhagic syndrome on the background of hyperhomocysteinemia had lower scores on the scales of physical functioning (96.25 points), school functioning (84.16 points), psychosocial health (84.40 points) and overall score (86.70 points) when compared with children with hemorrhagic syndrome, whose plasma homocysteine levels was within the normal range. The maximum difference in scores when comparing children of both groups was found on the scale of social functioning (13.3 points), followed by psychosocial health (12.0 points) and emotional functioning (11.8 points).
Conclusion. According to all studied parameters the quality of life in children without hemorrhagic manifestations is significantly higher. To prevent hyperhomocysteinemia and increase QOL in children with bleeding symptoms, rational folate-vitamin correction is advisable.
Contribution: Strozenko L.А., Lobanov Yu.F. — concept and design of the study; Ponomarev V.S., Sanina О.О. — collection and processing of the material; Ponomarev V.S., Strozenko L.А. — statistical processing of the material; Ponomarev V.S., Strozenko L.А. — writing the text; Lobanov Yu.F., Skudarnov E.V. — editing the text. All co-authors — approval of the final version of the article, responsibility for the integrity of all parts of the article.
Acknowledgments. The study had no sponsorship.
Conflict of interest. The authors declare no conflict of interest.

Received: January 23, 2026
Accepted: February 10, 2026
Published: February 27, 2026

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