Crossing syndrome of gastroesophageal reflux disease and of dispepsia in schoolchildren of ethnic populations of Siberia

Introduction. An essential point in the prevention and risk assessment of these diseases is identifying their predictors predisposing to a progressive course of inflammation in the gastroduodenal zone, particularly gastroesophageal reflux disease (GERD) intersection syndrome and dyspepsia syndrome (DS). A more unfavourable situation is observed among the indigenous — Mongoloid populations.

The aim of the study is to investigate the ethnic features of the prevalence and clinical manifestations of the intersection of GERD with DS in schoolchildren of Mongoloid and Caucasian populations of Tuva, Evenkia and Buryatia.

Material and methods. A cross-sectional survey was carried out on the presence of gastroenterological complaints in schoolchildren aged 7–17 years, followed by random gastroscopy with a biopsy of the gastric mucosa. Six hundred forty one Caucasians, 894 Mongoloids were examined in the Republic of Tuva; in Buryatia, there are 168 Caucasians, 622 Mongoloids; in Evenkia, there are 993 Caucasians, 376 Mongoloids. Endoscopically examined: in Tuva, 122 Caucasians, 158 Mongoloids; in Buryatia — 28 Caucasians, 82 Mongoloids; in Evenkia, there are 133 Caucasians, 71 Mongoloid.

Results. Among schoolchildren in the Siberian region, the prevalence of GERD overlap syndrome with DS was 4.7%. An increase in indices was noted among the Mongoloid populations: by 5.7% and 3.6% among Caucasians. Schoolchildren of Mongoloid populations with the overlapping syndrome often had a variant of dyspepsia with epigastric pain. At the same time, regardless of ethnicity, schoolchildren with intersection syndrome have an increased likelihood of forming erosive and ulcerative lesions of the mucous membrane of the gastroduodenal zone.

Conclusion. The syndrome of overlapping in Siberian schoolchildren has a more unfavourable course with features in the ethnic populations of Mongoloids and Caucasians.

Contribution:
Polivanova T.V., Vshivkov V.A. — concept and design of the study;
Kasparov E.V., Vshivkov V.A. — collection and processing of the material;
Polivanova T.V. — writing the text;
Vshivkov V.A. — editing.
All co-authors — approval of the final version of the article, responsibility for the integrity of all its parts.

Acknowledgement. The study had no sponsorship.

Conflict of interest. The authors declare no conflict of interest.

Received: November 19, 2021
Accepted: February 17, 2021
Published: March 15, 2021

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