Course of Helicobacter pylori-associated gastritis in adolescents with hypovitaminosis D

Introduction. The multifactorial nature of the occurrence and phasing of inflammatory changes in the gastric mucosa determine the need to search for conditions that can affect the slowing of the progression of gastritis in children.

Aim: to determine the manifestations of Helicobacter pylori-associated antrum gastritis in adolescents with hypovitaminosis D.

Material and methods. Ninety three 12–17 years adolescents with a morphologically confirmed diagnosis of gastritis were exa­mined. The content of vitamin D in the blood was determined using the ELISA method. Adolescents were divided into groups depending on the level of vitamin D supply and the period of solar insolation at the time of the examination.

Results. H. pylori infection in adolescents with hypovitaminosis D had a pronounced tendency to increase — 75% (53.6% in child­ren with sufficient vitamin D levels; p = 0.067).

The frequency of H. pylori among adolescents examined during low solar insolation was higher than during high solar insolation (p = 0.015). During the period of low solar insolation, the highest rates of H. pylori infection in children were found among adolescents with vitamin D deficiency (88.2% compared to 62.1% among children with a normal vitamin D supply; p = 0.057). During the period of high insolation, H. pylori infection was approximately the same (p = 0.82).

Antral gastritis with high activity was predominantly detected in adolescents infected with H. pylori and its frequency did not depend on the level of vitamin D in the blood.

Conclusion. Hypovitaminosis D is associated with H. pylori-associated gastritis, characterized by greater activity of the inflammatory process and has a clear relationship with the intensity of solar insolation.

Contribution: 
Anikina K.A., Polivanova T.V. — concept and design of the study;
Anikina K.A., Vshivkov V.A. — data collection and processing;
Anikina K.A. — statistical processing of the data, writing the text;
Polivanova T.V., Vshivkov V.A. — editing the text.
All co-authors — approval of the final version of the article, responsibility for the integrity of all parts of the article.

Acknowledgment. The study had no sponsorship.

Conflict of interest. The authors declare no conflict of interest.

Received: November 10, 2023
Accepted: November 28, 2023
Published: December 27, 2023

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