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Functional diseases of the digestive system with abdominal pain in school-age children

https://doi.org/10.46563/1560-9561-2024-27-3-212-217

EDN: tgcrlo

Abstract

Functional gastrointestinal diseases, accompanied by prolonged abdominal pain, significantly affect on the patients’ quality of life, regardless of their age and gender. So far, the diagnosis of such disorders remains challenging. Currently there is no consensus on the type and number of tests to be performed, or on the age at which children should be examined. Chronic abdominal pain may mask functional gastrointestinal disorders as well as organic diseases of various organs and systems. The analysis of modern ideas about functional diseases of the digestive system, accompanied by abdominal pain, is carried out.

Contribution:
Zokirov N.Z., Alieva E.I., Krasnov A.V., Sytkov V.V. — concept and design of the study;
Krasnov A.V., Sytkov V.V., Potapova N.A. — collection and processing of the material;
Krasnov A.V., Sytkov V.V. — writing the text;
Zokirov N.Z., Sytkov V.V. — editing the text.
All co-authors — approval of the final version of the article, responsibility for the integrity of all parts of the article.

Acknowledgment. The study had no sponsorship.

Conflict of interest. The authors declare no conflict of interest.

Received: May 20, 2024
Accepted: June 11, 2024
Published: July 12, 2024

About the Authors

Nurali Z. Zokirov
Research Clinical Center for Children and Adolescents of the FMBA of Russia; State Research Center — Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency; Academy of Postgraduate Education of Federal Clinical Research Centre of Russia’s Federal Medical-Biological Agency
Russian Federation

MD, PhD, DSci., prof., chief of nephrology of the Department of Federal Research Clinical Center for children and adolescents of the FMBA of Russian Federation; prof., head of the department of pediatrics and pediatric surgery MBU INO State Scientific Center FMBC named after. A.I. Burnazyan FMBA of Russia; prof., head department of pediatrics, Academy of Postgraduate Education FSBI Federal Scientific Center, FMBA of Russia

e-mail: nuraliz@mail.ru



Elmira I. Alieva
Research Clinical Center for Children and Adolescents of the FMBA of Russia; State Research Center — Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
Russian Federation


Arseniy V. Krasnov
State Research Center — Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency; Moscow Region Dolgoprudny Central Municipal Hospital
Russian Federation


Valentin V. Sytkov
Research Clinical Center for Children and Adolescents of the FMBA of Russia; Russian University of Medicine of the Ministry of Health of the Russian Federation
Russian Federation


Nataliya A. Potapova
Moscow Region Dolgoprudny Central Municipal Hospital
Russian Federation


References

1. Vernon-Roberts A., Alexander I., Day A.S. Systematic review of pediatric functional gastrointestinal disorders (Rome IV Criteria). J. Clin. Med. 2021; 10(21): 5087. https://doi.org/10.3390/jcm10215087

2. Baaleman D.F., Velasco-Benítez C.A., Méndez-Guzmán L.M., Benninga M.A., Saps M. Functional gastrointestinal disorders in children: agreement between Rome III and Rome IV diagnoses. Eur. J. Pediatr. 2021; 180(7): 2297–303. https://doi.org/10.1007/s00431-021-04013-2

3. Thapar N., Benninga M.A., Crowell M.D., Di Lorenzo C., Mack I., Nurko S. Paediatric functional abdominal pain disorders. Nat. Rev. Dis. Primers. 2020; 6(1): 89. https://doi.org/10.1038/s41572-020-00222-5

4. Chumpitazi B.P., Kearns G.L., Shulman R.J. Review article: the physiological effects and safety of peppermint oil and its efficacy in irritable bowel syndrome and other functional disorders. Aliment. Pharmacol. Ther. 2018; 47(6): 738–52. https://doi.org/10.1111/apt.14519

5. Zia J.K., Lenhart A., Yang P.L., Heitkemper M.M., Baker J., Keefer L., et al. Risk factors for abdominal pain-related disorders of Gut-Brain interaction in adults and children: A systematic review. Gastroenterology. 2022; 163(4): 995–1023.e3. https://doi.org/10.1053/j.gastro.2022.06.028

6. Di Nardo G., Barbara G., Borrelli O., Cremon C., Giorgio V., Greco L., et al. Italian guidelines for the management of irritable bowel syndrome in children and adolescents: Joint Consensus. Ital. J. Pediatr. 2024; 50(1): 51. https://doi.org/10.1186/s13052-024-01607-y

7. Savarino E., Zingone F., Barberio B., Marasco G., Akyuz F., Akpinar H., et al. Functional bowel disorders with diarrhoea: Clinical guidelines of the United European Gastroenterology and European Society for Neurogastroenterology and Motility. United European Gastroenterol. J. 2022; 10(6): 556–84. https://doi.org/10.1002/ueg2.12259

8. Zanchi C., Pintaldi S., Di Leo G., Ronfani L., Zamagni G., Viel M., et al. Fifteen-years follow-up in a cohort of children with functional gastrointestinal disorders: Prevalence and risk factors to develop neuropsychiatric disorders and other comorbidities. Children (Basel). 2021; 8(10): 838. https://doi.org/10.3390/children8100838

9. Belmer S.V., Volynets G.V., Gorelov A.V., Gurova M.M., Zvyagin A.A., Kornienko E.A., et al. Functional digestive disorders in children. Guidelines of Society of Pediatric Gastroenterologists, Hepatologists and Nutritionists. Part 1. Rossiyskiy vestnik perinatologii i pediatrii. 2020; 65(4): 150–61. https://doi.org/10.21508/1027-4065-2020-65-4-150-161 https://elibrary.ru/pdjrqg (in Russian)

10. Lacy B.E., Pimentel M., Brenner D.M., Chey W.D., Keefer L.A., Long M.D., et al. ACG clinical guideline: Management of irritable bowel syndrome. Am. J. Gastroenterol. 2021; 116(1): 17–44. https://doi.org/10.14309/ajg.0000000000001036

11. Camilleri M. Diagnosis and treatment of irritable bowel syndrome: a review. JAMA. 2021; 325(9): 865–77. https://doi.org/10.1001/jama.2020.22532

12. Légeret C., Stienen Y., Furlano R., Köhler H. Effectivity of treatment for children with functional dyspepsia. Sci. Rep. 2022; 12(1): 1467. https://doi.org/10.1038/s41598-022-05380-y

13. Shava U., Srivastava A., Mathias A., Kumar N., Yachha S.K., Gambhir S., et al. Functional dyspepsia in children: A study of pathophysiological factors. J. Gastroenterol. Hepatol. 2021; 36(3): 680–6. https://doi.org/10.1111/jgh.15193

14. Waseem S., Rubin L. A comprehensive review of functional dyspepsia in pediatrics. Clin. J. Gastroenterol. 2022; 15(1): 30–40. https://doi.org/10.1007/s12328-021-01561-w

15. Mayer E.A., Ryu H.J., Bhatt R.R. The neurobiology of irritable bowel syndrome. Mol. Psychiatry. 2023; 28(4): 1451–65. https://doi.org/10.1038/s41380-023-01972-w

16. Smirnova G.I., Korsunskiy A.A., Lyalikova V.B. Irritable bowel syndrome in children: new in diagnostics and treatment. Rossiyskiy pediatricheskiy zhurnal. 2016; 19(5): 309–18. https://doi.org/10.18821/1560-95612016-19(5)-309-318 https://elibrary.ru/wrlfxv (in Russian)

17. Sytkov V.V., Borovik T.E., Poddubny I.V., Vorobeva Yu.D., Zokirov N.Z., Trunov V.O., et al. Irritable bowel syndrome in pediatric practice. Focus on children with a history of surgical intervention. Voprosy prakticheskoy pediatrii. 2021; 16(5): 108–15. https://doi.org/10.20953/1817-7646-2021-5-108-115 https://elibrary.ru/bsbysy (in Russian)

18. Șchiopu C.G., Ștefănescu C., Boloș A., Diaconescu S., Gilca-Blanariu G.E., Ștefănescu G. Functional gastrointestinal disorders with psychiatric symptoms: Involvement of the microbiome-gut-brain axis in the pathophysiology and case management. Microorganisms. 2022; 10(11): 2199. https://doi.org/10.3390/microorganisms10112199

19. Smirnova G.I., Labinov V.S., Korsunsky A.A. Irritable bowel syndrome in children: pathogenetic significance of disorders of intestinal microbiota. Rossiyskiy pediatricheskiy zhurnal. 2024; 27(1): 49–54. https://doi.org/10.46563/1560-9561-2024-27-1-49-54 https://elibrary.ru/xqpypx (in Russian)

20. Mishima Y., Ishihara S. Molecular mechanisms of microbiota mediated pathology in irritable bowel syndrome. Int. J. Mol. Sci. 2020; 21(22): 8664. https://doi.org/10.3390/ijms21228664

21. Santucci N.R., Hyman P.E., Harmon C.M., Schiavo J.H., Hussain S.Z. Biliary dyskinesia in children: a systematic review. J. Pediatr. Gastroenterol. Nutr. 2017; 64(2): 186–93. https://doi.org/10.1097/MPG.0000000000001357

22. Simon D.A., Friesen C.A., Schurman J.V., Colombo J.M. Biliary dyskinesia in children and adolescents: A mini review. Front. Pediatr. 2020; 8: 122. https://doi.org/10.3389/fped.2020.00122

23. Kegnæs M., Novovic S., Shabanzadeh D.M. Dysfunction of biliary sphincter of oddi-clinical, diagnostic and treatment challenges. J. Clin. Med. 2023; 12(14): 4802. https://doi.org/10.3390/jcm12144802

24. Dicheva D.T., Goncharenko A.Yu., Zaborovskiy A.V., Privezentsev D.V., Andreev D.N. Functional disorders of the biliary tract: modern diagnostic criteria and principles of pharmacotherapy. Meditsinskiy sovet. 2020; (11): 116–23. https://doi.org/10.21518/2079-701X-2020-11-116-123 https://elibrary.ru/hsdehn (in Russian)

25. Edwards M.A., Mullenbach B., Chamberlain S.M. Pain provocation and low gallbladder ejection fraction with CCK cholescintigraphy are not predictive of chronic acalculous gallbladder disease symptom relief after cholecystectomy. Dig. Dis. Sci. 2014; 59(11): 2773–8. https://doi.org/10.1007/s10620-014-3213-4

26. Alhayo S., Eslick G.D., Cox M.R. Cholescintigraphy may have a role in selecting patients with biliary dyskinesia for cholecystectomy: a systematic review. ANZ J. Surg. 2020; 90(9): 1647–52. https://doi.org/10.1111/ans.16003

27. Lin Z., Wang Y., Lin S., Liu D., Mo G., Zhang H. et al. Identification of potential biomarkers for abdominal pain in IBS patients by bioinformatics approach. BMC Gastroenterol. 2021; 21(1): 48. https://doi.org/10.1186/s12876-021-01626-7

28. Pawlik K., Mika J. Targeting members of the chemokine family as a novel approach to treating neuropathic pain. Molecules. 2023; 28(15): 5766. https://doi.org/10.3390/molecules28155766

29. Shin A., Kashyap P.C. Multi-omics for biomarker approaches in the diagnostic evaluation and management of abdominal pain and irritable bowel syndrome: what lies ahead. Gut Microbes. 2023; 15(1): 2195792. https://doi.org/10.1080/19490976.2023.2195792

30. Sibirskaya E.V., Rashoyan K.S., Filatova M.A. Differential diagnosis of chronic abdominal pain in children and adolescents. Effektivnaya farmakoterapiya. 2023; 19(23): 58–63. https://doi.org/10.33978/2307-3586-2023-19-23-58-63 https://elibrary.ru/uqojnp (in Russian)

31. Maev I.V., Andreev D.N., Zaborovsky A.V., Lobanova E.G. Functional gastrointestinal diseases: mechanisms of development and principles of multitarget therapy. Meditsinskii sovet. 2022; 16(7): 8–14. https://doi.org/10.21518/2079-701X-2022-16-7-8-14 https://elibrary.ru/piqxwm (in Russian)

32. Korterink J.J., Diederen K., Benninga M.A., Tabbers M.M. Epidemiology of pediatric functional abdominal pain disorders: a meta-analysis. PLoS One. 2015; 10(5): e0126982. https://doi.org/10.1371/journal.pone.0126982

33. Bao X., Yu W., Chu Z., Gao J., Zhou M., Gu Y. Functional abdominal pain disorders in children in southern Anhui Province, China are related to academic stress rather than academic performance. BMC Pediatr. 2023; 23(1): 333. https://doi.org/10.1186/s12887-023-04154-3

34. Peralta-Palmezano J.J. Prevalence of functional gastrointestinal disorders in school children and adolescents. Korean J. Gastroenterol. 2019; 73(4): 207–12. https://doi.org/10.4166/kjg.2019.73.4.207

35. Karami H., Lashtoo Aghaee B., Yazdani Charati J., Abedi A. Quality of life for children with functional abdominal pain and their parents copmared to healthy individuals. J. Pediatr. Rev. 2022; 10(3): 267–72. https://doi.org/10.32598/jpr.10.3.1018.1

36. Feeny D., Furlong W., Torrance G.W., Goldsmith C.H., Zhu Z., DePauw S., et al. Multiattribute and single-attribute utility functions for the Health Utilities Index Mark 3 system. Med. Care. 2002; 40(2): 113–28. https://doi.org/10.1097/00005650-200202000-00006

37. Vinyarskaya I.V., Chernikov V.V., Terletskaya R.N., Shcherbakova S.V., Fetisova A.N. Validation of the Russian version of a questionnaire for the assessment of utilitarian indices in pediatric practice. Stage II. Voprosy sovremennoi pediatrii. 2014; 13(4): 20–5. https://elibrary.ru/sngfsj (in Russian)

38. Puka K., Conway L., Smith M.L. Quality of life of children and families. In: Handbook of Clinical Neurology. Volume 174. Elsevier: 2020: 379–88. https://doi.org/10.1016/B978-0-444-64148-9.00028-4

39. He S., Chen L., Wang P., Xi X. Psychometric comparison of EQ-5D-Y, CHU-9D, and PedsQL 4.0 in Chinese children and adolescents with functional dyspepsia: a multi-center study. Value Health. 2023; 26(12): 1754–62. https://doi.org/10.1016/j.jval.2023.08.007

40. Holtman G.A., Lisman-van Leeuwen Y., Kollen B.J., Norbruis O.F., Escher J.C., Walhout L.C., et al. Diagnostic test strategies in children at increased risk of inflammatory bowel disease in primary care. PLoS One. 2017; 12(12): e0189111. https://doi.org/10.1371/journal.pone.0189111

41. Ansems S.M., Berger M.Y., Pieterse E., Nanne S., Beugel G.G., Couwenberg R.P.E., et al. Management of children with non-acute abdominal pain and diarrhea in Dutch primary care: a retrospective cohort study based on a routine primary care database (AHON). Scand. J. Prim. Health Care. 2023; 41(3): 267–75. https://doi.org/10.1080/02813432.2023.2231054

42. Santucci N.R., Saps M., van Tilburg M.A. New advances in the treatment of paediatric functional abdominal pain disorders. Lancet Gastroenterol. Hepatol. 2020; 5(3): 316–28. https://doi.org/10.1016/S2468-1253(19)30256-0.36

43. Trivić I., Hojsak I. Initial diagnosis of functional gastrointestinal disorders in children increases a chance for resolution of symptoms. Pediatr. Gastroenterol. Hepatol. Nutr. 2018; 21(4): 264–70. https://doi.org/10.5223/pghn.2018.21.4.264

44. Llanos-Chea A., Saps M. Utility of diagnostic tests in children with functional abdominal pain disorders. Gastroenterol. Hepatol. (N. Y.). 2019; 15(8): 414–22.

45. Saini S., Narang M., Srivastava S., Shah D. Behavioral intervention in children with functional abdominal pain disorders: A promising option. Turk. J. Gastroenterol. 2021; 32(5): 443–50. https://doi.org/10.5152/tjg.2021.20679


Review

For citations:


Zokirov N.Z., Alieva E.I., Krasnov A.V., Sytkov V.V., Potapova N.A. Functional diseases of the digestive system with abdominal pain in school-age children. Russian Pediatric Journal. 2024;27(3):212-217. (In Russ.) https://doi.org/10.46563/1560-9561-2024-27-3-212-217. EDN: tgcrlo

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ISSN 1560-9561 (Print)
ISSN 2413-2918 (Online)