The article presents a clinical report of the use of a new drug of the janus kinase inhibitor, upadacitinib, possessing of the effect on the intracellular JAK/STAT system, the role of which in the pathogenesis of atopic dermatitis (AD) is being actively studied. JAK/STAT includes janus kinases JAK1, JAK2, JAK3, tyrosine kinase, protein-transductor and transcription activator (STAT). When the cytokine interacts with the corresponding receptor, janus kinases phosphorylate STAT proteins inducing transcription of genes that mediate the action of key cytokines to trigger the development of an inflammatory response in the shock organ. Upadacitinib is recommended for uncontrolled AD patients older 12 years. The use of upadacitinib in a 17-year-old patient at a dose of 15 mg in tablets, daily, has shown high efficacy in achieving clinical remission of AD and complete relief of the skin itching.

Contribution:
Revyakina V.A., Larkova I.A. — concept and design of the work;
Mukhortykh V.A., Glukhova E.A., Kuvshinova E.D., Timofeeva A.M. — preparation of the material;
Revyakina V.A., Larkova I.A. — writing the text.
All co-authors — approval of the final version of the article, responsibility for the integrity of all parts of the article.

Acknowledgment. The study had no sponsorship.

Conflict of interest. The authors declare no conflict of interest.

Received: June 07, 2022
Accepted: June 29, 2022
Published: August 30, 2022

This review is devoted to an urgent and insufficiently studied problem — the characteristics of the pubertal development of girls with cystic fibrosis (CF), the deviations in the period of menarche, the stages of the puberty, anatomical and physiological features of the female reproductive system in this monogenic disease. The increase in life expectancy, as well as the spread and increasing availability of targeted therapies, highlight the need for further research on this topic. Early diagnosis of disorders of pubertal development due to timely prescribed therapy (hormonal) allows not only correcting the timing of the onset of menarche in CF adolescent girls, but also increasing the chances of conceiving and bearing a child.

Contribution:
Goryainova A.V., Karachentsova I.V., Sibirskaya E.V., Sharkov S.M. — research concept and design of the study;
Goryainova A.V., Golubkova V.M., Bondarenko O.V., Karachentsova I.V. — collection and processing of material;
Goryainova A.V., Golubkova V.M., Bondarenko O.V., Karachentsova I.V. — text writing;
Bondarenko O.V., Go­lubkova V.M., Karachentsova I.V. — editing.
All co-authors — approval of the final version of the article, responsibility for the integrity of all parts of the article.

Acknowledgment. The study had no sponsorship. 

Conflict of interest. The authors declare no conflict of interest. 

Received: June 16, 2022
Accepted: June 29, 2022
Published: 30 August, 2022

The literature review shows fetoinfantile losses to characterize not only the health of the population and its reproductive potential, but also the social and economic living conditions of the population, the medical care quality, the implementation of modern technologies. They are believed to have a significant impact on basic socio-demographic indicators. According to WHO recommendations, this integrated indicator should be used as a new methodological approach to analyze the activities of maternity and childhood services, to develop the most effective management decisions for the prevention of infant and perinatal mortality. The review presents the features of birth registration in Russia since the adoption by the WHO General Assembly in 1950 of definitions and criteria of such perinatal concepts as “live-born”, “stillborn”, “viable fetus”, “abortion” corresponding to world ethical concepts to the present. The complete transition to international birth registration criteria in 2012 was the most important event in the further reduction of fetoinfantile losses in the country. Thus, the inclusion of infants with extremely low body weight in the number of live births required the use of the highest technologies not only to prevent death, but also their disability, domestic statistics indicators of fetoinfantile losses have become more reliable and comparable to international ones. In the context of the new requirements to birth registration, an analysis of the infant mortality accounting in the regions of Russia was carried out according to five specially developed criteria, as well as the reconstruction of its indicators using a recalculation model for the level of postnatal mortality. It was established that the unreliable presentation of information continues — there is a repetition of the trends observed in previous years, only the extreme weight category has changed. Provided data show the validity of the proposed infant mortality undercount criteria, allowing researchers to recommend them for use in practical healthcare.

Acknowledgment. The study had no sponsorship.

Conflict of interest. The author declares no conflict of interest.

Received: June 15, 2022
Accepted: June 29, 2022
Published: August 30, 2022